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Objective: To identify signature proteins potentially linked to resistance to autoimmunity in the blood of centenarians. Methods: We conducted in silico data mining of previously published proteomic results using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) and PHENOPEDIA databases. Results: Sixteen autoimmune disease-related proteins were identified within the proteomi

Brake particle emissions present significant risks to human health, particularly when they contain metallic fine particles, which can induce oxidative stress, disrupt cellular structures, and cause genetic damage. In this study, an alumina coating was deposited on cast iron discs and a non-asbestos organic (NAO) pad and a low-metallic (LM) pad (as reference) were used as counterparts of the brake

Dietary fibers are recognized for their health benefits, yet cancer patients undergoing pelvic radiotherapy are often advised to reduce fiber intake. This may negatively impact their bowel health. To evaluate the effects of dietary fibers on bowel health post-irradiation, male C57BL/6 mice were fed diets containing either 0 or 15% fiber with varying proportions of readily fermentable bioprocessed

Introduction: Generalised anxiety disorder (GAD) in older adults involves excessive worry and cognitive challenges. Verbal memory impairments is associated to hippocampal dysfunction, with cortisol and brain-derived neurotrophic factor (BDNF) being important in hippocampal integrity. Research on hippocampal volume and verbal memory in older adults with GAD is limited, with mixed findings. This stu

Background: Countries around the world have committed to universal health coverage (UHC), a global vision that affirms the right for all people to access essential healthcare, when and where they need it and regardless of their ability to pay. UHC, as a political commitment, developed as part of the Sustainable Development Agenda in 2015 and, more recently, at the United Nations High-Level meeting

Many factors influence the language environment in preschool, for example, the language background and competence of the teachers, children's ages, language proficiency levels and language backgrounds, the access to play and learning materials and the composition of preschool groups. There is a lack of knowledge on how various aspects of the interactive language environment in preschool relate to

This study aimed to investigate the potential impact of neighborhood deprivation on the incidence of type 2 diabetes mellitus (T2DM) among individuals with asthma. This nationwide, open cohort study conducted in Sweden from 1997 to 2018 included asthma patients of all ages (n = 1,051,240) to assess their subsequent risk of developing T2DM. The study compared asthma patients residing in highly depr

This work presents an alternative cetane rating method using a production compression ignition (CI) engine, offering an accessible approach for preliminary fuel evaluation without the need for specialized equipment. As part of this work, an empirical correlation was developed linking ignition delay (ID) to both the cetane number (CN) and intake oxygen concentration. The test method follows the pri

From June to November 1945, over 70 shipments of flat-packed architectural elements arrived at the harbours of Nexø and Rønne on the Danish island Bornholm. The shipments consisted of prefabricated interior fixtures and ready-to-be mounted walls. The Danish municipality prepared infrastructure, named new roads, and within a year, 300 wooden houses were assembled on site. The buildings, SvenskehuseFrom June to November 1945, over 70 shipments of flat-packed architectural elements arrived at the harbours of Nexø and Rønne on the Danish island Bornholm. The shipments consisted of prefabricated interior fixtures and ready-to-be mounted walls. The Danish municipality prepared infrastructure, named new roads, and within a year, 300 wooden houses were assembled on site. The buildings, Svenskehuse

This paper takes its point of departure in the planned, but later stopped, memorial over the Utöya massacre in Norway. The suggested memorial called Memory Wound was designed by Swedish artist Jonas Dahlberg and would in reality become two memorials, one at Utöya and one in Olso. Examining the debate that eventually led to the cancellation of the planned memorial project, the paper raises question

The Eocene period experienced several hyperthermal events with the Paleocene-Eocene Thermal Maximum being the most significant. During this event, global mean surface temperatures were 5–6 °C higher and latitudinal temperature gradients were reduced compared to the late Paleocene. Unlike marine temperature records, terrestrial archives are limited, posing challenges for testing climate model compe

Rare preleukemic hematopoietic stem cells (pHSC) harboring only the initiating mutations can be detected at the time of acute myeloid leukemia (AML) diagnosis. pHSCs are the origin of leukemia and a potential reservoir for relapse. Using primary human samples and gene editing to model isocitrate dehydrogenase 1 (IDH1) mutant pHSCs, we show epigenetic, transcriptional, and metabolic differences bet

Introduction Ischaemia-reperfusion (I/R) injury remains a major challenge in heart transplantation, with mortality risk increasing significantly when allograft ischaemic time exceeds 4 hours. Non-ischaemic heart preservation (NIHP), using continuous hypothermic perfusion, has shown promise in preliminary studies for reducing I/R injury and improving outcomes. This randomised controlled trial aims

Objectives: To quantify the influence of lifestyle factors on tumour necrosis factor inhibitor (TNFi) treatment response, in axial spondyloarthritis (axSpA). Methods: Data on biologics-naïve adults with axSpA were captured from European rheumatology registries. Information on lifestyle factors (smoking, overweight/obesity, and/or alcohol consumption) were identified ± 30 days of commencing their f

The main subject of this thesis is the proof of the Prime Number Theorem. It revolves around the Riemann zeta function, whose continuation to a meromorphic function in the complex plane is discussed. We employ auxiliary functions, including the Chebyshev function, to simplify the proof of the theorem to showing an equivalent statement.

OBJECTIVES: Penicillin V (PcV) is considered the first-line treatment for community-acquired pneumonia in Scandinavian countries, although data supporting this recommendation are scarce. Thus, this study aimed to compare PcV and amoxicillin regarding the risk of treatment failures in children aged >5 years and adults treated for pneumonia in primary care.METHODS: In this retrospective study of hea

The investigation of carbon monoxide (CO) adsorption on the unreconstructed Ir(100)-(1 × 1) surface under ultra-high vacuum (UHV) conditions is studied with scanning tunneling microscopy (STM), low-energy electron diffraction (LEED), and high-resolution core-level spectroscopy (HRCLS). At a low coverage of 0.5 ML (monolayer), CO molecules adopt a previously documented c(2 × 2) structure, having CO

A novel approach combining 3D printing, phase inversion, and microwave plasma-enhanced chemical vapor deposition is presented. This technique enables the creation of carbon-based electrodes with precise micro- and nanoscale control, offering potential for sustainable and high-performance wastewater treatment applications. The synthesized 3D carbon scaffolds, enriched with B,N-doped carbon nanostru

Over the last century, district heating (DH) has only achieved global market shares of around 10 %. To reach its potential market shares of 25–50 % in Europe by 2050, growth must drastically accelerate. But deployment of DH is hindered by barriers, potentially slowing this fast-paced transition of the heat system. In this paper, we identify barriers to the deployment of DH through manual and GPT-a