Parkinson's Disease (PD) is the second most common neurodegenerative disorder of the central nervous system. Motor symptoms are the focus of pharmacotherapy, yet non-motor features of the disease (e.g. fatigue, mood disturbances, sleep disturbances and symptoms of anxiety) are both common and disabling for the patient. The pathophysiological mechanisms behind the non-motor symptoms in PD are yet t

Increased epithelial cell expression of the cyclooxygenase-2 (COX-2) enzyme is a characteristic event of both inflammatory bowel disease and colon cancer. We here report the novel findings that collagen I-induced de novo synthesis of COX-2 in intestinal epithelial cells is inhibited by pertussis toxin (PTX) and by an inhibitory peptide selective for the heterotrimeric G alpha(i3)-protein. These fi

A new collaborative program, the FERRUM project. aims at extending and improving the database of oscillator strengths for the astrophysical important Fe II spectrum. In this paper we report on the experimental method applied for measurements of radiative lifetimes of Fe II levels at intermediate excitation (5-10 eV) that can be populated ba laser excitation from metastable states. The technique in

BACKGROUND: In settings with low background prevalence of tuberculosis (TB) infection, interferon-gamma release assays (IGRA) could be useful for diagnosing active TB. This study aims to evaluate the performance of QuantiFERON-TB Gold (QFT-G) in the investigation for suspected active TB, with particular attention to patients originating in high-incidence countries. Furthermore, factors associated

Let $\Omega$ be a domain in the complex plane, $\phi$ an analytic map that maps $\Omega$ into itself, and $X$ an $F$-space of analytic functions in $\Omega$ that possesses certain mild regularity properties. (Some examples considered in the paper are Hardy spaces, Bergman spaces, and the space of all analytic functions in $\Omega$.) If composition with $\phi$ defines a compact operator on $X$ that

PURPOSE: HAMLET is a protein-lipid complex that kills different types of cancer cells. Recently we observed a rapid reduction in human bladder cancer size after intravesical HAMLET treatment. In this study we evaluated the therapeutic effect of HAMLET in the mouse MB49 bladder carcinoma model. MATERIALS AND METHODS: Bladder tumors were established by intravesical injection of MB49 cells into poly

Information and communication are increasingly being conveyed over the Internet. The forms of service and commerce that we are familiar with today will most likely be reduced in scale in the future to be replaced by new electronic solutions. For this reason, it is important that new technology be designed so that as many people as possible can utilize it. Accessibility to a range of services and i

Popular Abstract in Swedish Det här arbetet handlar om simuleringar av porösa material och transportfenomen vid en mesoskopisk längdskala, det vill säga en längdskala större än en enskild atom men mindre än att alla atomer beter sig som en kontinuerlig enhet. De porösa material som har studerats är membran som används i bränsleceller. Masstransport har även studerats i membranet. Värme- och masstrThe topic of this work is simulations of porous materials and transport phenomena at a mesoscopic length scale, i.e., a length scale larger than an individual atom but smaller than the continuum. The porous material studied is a membrane used in fuel cells. Mass transfer has also been studied in the membrane. Heat and mass transfer has been studied in parallel plate channels, first in saturated ch

Under 1988 påbörjades vid Lunds Tekniska Högskola ett forskningsprojekt rörande kalkutfällning på putsade och målade fasader. Här redovisas problemställningar och vissa resultat. Dessutom tas en diskussion upp rörande den produktinformation som ges av materialtillverkarna.

Human C4b-binding protein (C4BP) is a soluble, multiple-subunit inhibitor of complement that circulates in blood. Recently C4BP was shown to bind DNA, reduce DNA release from necrotic cells and limit DNA-mediated complement activation in solution. Herein we employed nuclear magnetic resonance spectroscopy to measure chemical shift perturbations and used them to restrain the computational docking o