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Integrin alpha 10 beta 1 is a collagen-binding integrin expressed on chondrocytes. In order to unravel the role of the alpha 10 integrin during development, we generated mice carrying a constitutive deletion of the alpha 10 integrin gene. The mutant mice had a normal lifespan and were fertile but developed a growth retardation of the long bones. Analysis of the skeleton revealed defects in the gro

The intermolecular electrostatic and induction energy of a NEMO potential which includes intramolecular polarization, are compared with a regular NEMO potential and a NEMO potential with configurationally dependent local properties. It is shown that the inclusion of intramolecular polarization improves the description of the intermolecular interactions when using the NEMO potential. (c) 2009 Wiley

The effects of nitrogen ion sputtering and thermal anneal processing on the surface electronic structure of the ternary III-V semiconductor In0.12Ga0.88N have been studied using scanning photoemission microscopy. No phase separation of the material is observed for annealing temperatures up to 650degreesC. However, samples annealed at 700degreesC for 5 h show clear evidence of phase separation. Fur

Objective: To investigate the relationship between memory and intensive care sedation. Design and setting: Prospective cohort study over 18 months in two general intensive care units (ICUs) in district university hospitals. Patients: 313 intubated mechanically ventilated adults admitted for more than 24 h, 250 of whom completed the study. Measurements: Patients (n = 250) were interviewed in the wa

The Gaussian wave model has been successfully used in ocean engineering for more than half a century. It is well understood, and there exists both exact theory and efficient numerical algorithms for calculation of the distribution of safety related wave characteristics, such as crest height and steepness. Its drawback is its lack of realism: it produces waves which are stochastically symmetric, bo

Objective. To search for primary hyperaldosteronism (PHA) among previously known hypertensive patients in primary care, using the aldosterone/renin ratio (ARR), and to evaluate clinical and biochemical characteristics in patients with high or normal ratio. Design. Patient survey study. Setting and subjects. The study population was recruited by written invitation among hypertensive patients in two

Neisseria gonorrhoeae is the causative agent of gonorrhea, a disease that is restricted to humans. Complement forms a key arm of the innate immune system that combats gonococcal infections. N. gonorrhoeae uses its outer membrane porin (Por) molecules to bind the classical pathway of complement down-regulatory protein C4b-binding protein (C4bp) to evade killing by human complement. Strains of N. go

The paper describes briefly the present and future accelerator vacuum systems at MAX-lab, a national laboratory for synchrotron radiation and nuclear physics in Lund, Sweden. The present accelerator systems at MAX-lab, with the 500 MeV MAX I, the 1.5 GeV MAX II, and the 700 MeV MAX III storage rings, contain a variety of different vacuum pumps. In all three storage rings ion pumps and Titanium Sub

Children with specific language impairment (SLI) are often described as having great difficulty with grammatical morphology, but most studies have focused only on these childrens use of verb morphology. In this study, we examined the use of noun phrase (NP) morphology by preschool-age children with SLI who are acquiring Swedish. Relative to typically developing same-age peers and younger peers mat

We review postcopulatory phenomena in the Swedish sand lizard (Lacerta agilis) and adder (Vipera berus), and in particular, links between female promiscuity, determinants of paternity, and offspring viability. In both species, females mate multiply and exhibit a positive relationship between the number of partners and offspring viability. We conclude that this relationship is most likely the resul

The formation of ordered structure, such as crystallites, in starch was studied by means of differential scanning calorimetry (DSC). The influence of time/temperature treatment and additives such as polyethylene glycol (PEG), bovine serum albumin (BSA) and a carbonate buffer on the formation was investigated. The experiments were planned with a CCC (Central Composite Circumscribed) design. For all

Statistical downscaling models for precipitation in Scania, southern Sweden, have been developed and applied to calculate the changes in the future Scanian precipitation climate due to projected changes in the atmospheric composition. The models are based on multiple linear regression, linking large-scale predictors at monthly time resolution to regional statistics of daily precipitation on a mont

Background: The spectrum of human non-pylori Helicobacter infections is expanding, with species such as H. heilmannii and H. felis occasionally being associated with gastritis. However, the existence of non-pylori Helicobacter colonization in asymptomatic subjects has not been evaluated. The aim of this study was to investigate whether Helicobacter species other than pylori are present in the uppe

We have used proton magnetic relaxation dispersion (MRD) to study the self-association of bovine ß-lactoglobulin variant A (BLG-A) as a function of temperature at pH 4.7 (dimer–octamer equilibrium) and as a function of NaCl concentration at pH 2.5 (monomer–dimer equilibrium). The MRD method identifies coexisting oligomers from their rotational correlation times and determines their relative popula

Larsson PG, Bergstrom M. Forsum U, Jacobsson B, Strand A, Wolner-Hanssen P Bacterial vaginosis. Transmission, role in genital tract infection and pregnancy outcome: an enigma. APMIS 2005; 113:233-45. Whether bacterial vaginosis (BV) is acquired from an endogenous or an exogenous source is subject to controversy Despite findings of an association between sexual behaviour and BV some data indicate t