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The current conceptualization of Alzheimer disease (AD) is driven by the amyloid hypothesis, in which a deterministic chain of events leads from amyloid deposition and then tau deposition to neurodegeneration and progressive cognitive impairment. This model fits autosomal dominant AD but is less applicable to sporadic AD. Owing to emerging information regarding the complex biology of AD and the ch
The Common Correlated Effects (CCE) methodology is now well established for the analysis of factor-augmented panel models. Yet, it is often neglected that the pooled variant is biased unless the cross-section dimension (N) of the dataset dominates the time series length (T). This is problematic for inference with typical macroeconomic datasets where T often equal or larger than N. Given that an an
When working with system development and design, one is urged to write design documentation. The design document should be constructed in a specific way and should include all necessary information. However, the users of the design document are not stated and seem to be secondary. This study's aim is therefore to investigate who the users are. A literature review was conducted to answer the questi
In this paper, a set of indicators is presented that aim to identify promising service innovations for Accessibility as a Service (AaaS) and Mobility as a Service (MaaS); services that potentially can reduce the demand for transport and optimize use of transport infrastructure and vehicles in urban regions. The proposed indicators characterize service innovations from three different perspectives:
The paradigm shift of focus from rental apartments to owner-occupied units on the Swedish property market has led to a substantial number of rental apartments being converted to cooperative apartments. Such conversions are typically done at prices below market value. This provides strong financial incentives for tenants involved in such a conversion to use their informational advantage regarding t
Background: Whether high dairy consumption is related to longevity is still unclear, and additional studies of prospective cohorts with high-quality dietary data from populations with wide consumption ranges are needed. Objective: To examine the association between dairy consumption and mortality in a Swedish cohort. Design: Among 26,190 participants (62% females, 45-73 years old) without diabetesBackground: Whether high dairy consumption is related to longevity is still unclear, and additional studies of prospective cohorts with high-quality dietary data from populations with wide consumption ranges are needed. Objective: To examine the association between dairy consumption and mortality in a Swedish cohort. Design: Among 26,190 participants (62% females, 45-73 years old) without diabetes
As the conflict in Thailand’s southern border provinces shows no signs of abating, this article examines why Malay Muslims have managed to co-exist alongside the Thai Buddhists and the Sino-Thai population. Based on fieldwork, this article argues that while various factors have hardened ethno-religious identities and strengthened boundaries between ‘the other’ which in turn have affected inter-eth
The time evolution of a two-component collisionless plasma is modelled by the Vlasov–Poisson system. In this work, the setting is two and one-half dimensional, that is, the distribution functions of the particles species are independent of the third space dimension. We consider the case that an external magnetic field is present in order to confine the plasma in a given infinitely long cylinder. A
This paper presents a bottom boundary layer model for the unsteady and non-uniform flow in the swash zone, by extending the momentum integral method so as to include spatial gradients. The developed model is further incorporated into a hydrodynamic model based on the Nonlinear Shallow Water Equations. Two swash zone cases are examined to investigate the effect of the inclusion of spatial gradients
While the general literature analysing mobility patterns in Thailand’s southern border provinces largely indicates insecurity and violence as precipitating factors for migration, such explanations fail to fully explain why the majority of those who migrate do so within the conflict area rather than away from it. Based on fieldwork, this article argues that while a lack of security measures and hig
Artikeln undersöker svenska etniska organisationers verksamheter i syfte att belysa hur detta organisatoriska fält har förändrats under de senaste decennierna. Studien bygger på en totalundersökning av de 52 riksförbund som fått bidrag från Myndigheten för ungdoms- och civilsamhällesfrågor (MUCF). Den visar att det etniska organisationsfältet kännetecknas av både kontinuitet och förändring. Kultur
Purpose: The purpose of this study was to systematically search for long-term complications, including Nephrogenic Systemic Fibrosis (NSF), in patients who were previously administered the gadolinium-based contrast agent Gadofosveset at our institute. Materials and methods: All patients who were administered Gadofosveset at our institute between 2006 and 2009 were identified in our Radiological In
A light-yield calibration of an NE 213A organic liquid scintillator detector has been performed using bothmonoenergetic and polyenergetic gamma-ray sources. Scintillation light was detected in a photomultipliertube, and the corresponding pulses were subjected to waveform digitization on an event-by-event basis. Theresulting Compton edges have been analyzed using a GEANT4 simulation of the detector
Although co-infections and interactions of parasites are a very common phenomenon in the wild, information received from studies on avian Plasmodium spp. is scarce and fragmented due to its complex nature. Different interactions of parasites and domination of one parasite may have a detrimental effect on transmission success of another pathogen. Untangling these interactions and competitive behavi
In statistics, samples are drawn from a population in a data generating process (DGP). Standard errors measure the uncertainty in sample estimates of population parameters. In science, evidence is generated to test hypotheses in an evidence generating process (EGP). We claim that EGP variation across researchers adds uncertainty: non-standard errors. To study them, we let 164 teams test six hypoth
Increasing the application of machine learning algorithms in engine development has the potential to reduce the number of experimental runs and the computation cost of computational fluid dynamics simulations. The objective of this study is to assess if such a statistical modelling approach can predict engine efficiency and emissions at any given condition for an already calibrated spark ignition
Background and purpose: An earlier prospective randomised multicentre study (ARTSCAN) in head and neck cancer patients that compared conventionally fractionated radiotherapy (CF) with accelerated radiotherapy (AF) was inconclusive. In the subgroup of oral cavity squamous cell cancer (OCSCC) a large absolute, but not statistically significant, difference in local control was seen in favour of AF. T
Diffusion-relaxation correlation NMR can simultaneously characterize both the microstructure and the local chemical composition of complex samples that contain multiple populations of water. Recent developments on tensor-valued diffusion encoding and Monte Carlo inversion algorithms have made it possible to transfer diffusion-relaxation correlation NMR from small-bore scanners to clinical MRI syst
