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Human host defense peptide LL-37 facilitates double-stranded RNA pro-inflammatory signaling through up-regulation of TLR3 expression in vascular smooth muscle cells

OBJECTIVE: The importance of human host defense peptide LL-37 in vascular innate immunity is not understood. Here, we assess the impact of LL-37 on double-stranded RNA (dsRNA) signaling in human vascular smooth muscle cells.MATERIALS AND METHODS: Cellular import of LL-37 and synthetic dsRNA (poly I:C) were investigated by immunocytochemistry and fluorescence imaging. Transcript and protein express

Rural Income Diversification, Employment, and Differentiation in Kenya and Implications for Rural Change

To contribute to contemporary rural development debates, the present thesis conducts a contextual analysis of rural development using Kenya as a case study from the colonial era to today. To perform the analysis, two critical trends in rural Africa are focused on: socioeconomic differentiation and rural income diversification, with a particular focus on large-scale farm employment. By pointing to