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Background and Purpose: Possibilities to age in place are increasingly important with the demographic shift toward aging populations. With the Person-Place Fit Measure for Older Adults (PPFM-OA), older adults self-assess how their home and community environments suit their needs. The aim of the study was to evaluate the psychometric properties of the Swedish version of PPFM-OA. Methods: Four hund
Despite their emancipatory aspirations, collective entrepreneurial efforts to change organizations bottom-up are often complicit with the power structures they seek to transform. Our study takes a closer look at how workers experience and deal with the tensions between emancipation and complicity and how this can inform the entrepreneurial process. Empirically, we draw from a qualitative single-ca
The urgency to reimagine neoliberal capitalism challenges scholars to explore how we can organize alternatively. In this paper, we argue that a feminist ethics of care, which stresses our fundamental interdependence and responsibility to particular others, provides a novel relational understanding of the organization and maintenance of alternativity. Relying on an ethnography of a campaign and con
Pharmaceutical companies spend hundreds of millions of pounds on marketing/R&D-related payments annually to healthcare organisations and healthcare professionals. UK pharmaceutical industry self-regulatory bodies require member companies who sign up to their code of conduct to publish details of their payments. They are also required to publish the methodologies underlying these payments, name
We describe and demonstrate our work on multimodal filtered vector search in tabular data. It offers a practical way for businesses to vectorize their product assortments or any other business-critical data and then simultaneously retrieve and filter this information using state-of-the-art similarity search. Our methodology is based on the extended vector space model, with multiple modalities repr
Background: Patients with advanced ovarian cancer (AOC) undergoing surgery are often subjected to red blood cell (RBC) transfusions. Both anemia and RBC transfusion are associated with increased morbidity. The aim was to evaluate patient recovery after the implementation of patient blood management (PBM) strategies.Methods: This retrospective cohort study included 354 patients with AOC undergoing
This work demonstrates the utility of dual-arm robots with dual-wrist force-torque sensors in manipulating a Deformable Linear Object (DLO) within an unknown environment that imposes constraints on the DLO’s movement through contacts and fixtures. We propose a strategy to estimate the pose of unknown environmental contacts encountered during the manipulation of a DLO, classifying the induced const
The complement system, a crucial part of the innate immune system, protects the human body during bacterial infections. Complement comprises three pathways, classical, lectin, and alternative, which activate as a protein cascade. Activation of these pathways leads to the opsonization of pathogens with C3 fragments for phagocytosis, chemotaxis of phagocytes to the infection site, and deposition of
Ex-situ Raman spectroscopy is a well-established method for the structural characterization of soot but necessitates a sampling step before analysis is made. This work studied the potential to perform Raman spectroscopic measurements of soot directly in the combustion exhaust gases, i.e., online Raman measurements. Two types of soot were produced from a Mini-CAST soot generator, one immature with
We have previously investigated the biodistribution and therapy effect of a humanized monoclonal antibody targeting free prostate-specific antigen (fPSA) intended for theranostics of hormone-refractory prostate cancer. In the present study, we evaluated the off-target effect and different linear energy transfer (LET) radionuclides without the effect of PSA targeting by using an antibody with the s
Environmentally friendly InP-based quantum dots (QDs) are promising for light-emitting diodes (LEDs) and display applications. So far, the synthesis of highly emitting InP-based QDs via safe and economically viable amine-phosphine remains a challenge. Herein, we report the synthesis of amine-phosphine based InP/ZnSe/ZnS QDs by introducing an alloyed oxidation-free In-ZnSe transition layer (TL) at
The urea cycle enzyme argininosuccinate lyase (ASL) enables the clearance of neurotoxic ammonia and the biosynthesis of arginine. Patients with ASL deficiency present with argininosuccinic aciduria, an inherited metabolic disease with hyperammonemia and a systemic phenotype coinciding with neurocognitive impairment and chronic liver disease. Here, we describe the dysregulation of glutathione biosy
BACKGROUND: Dual antiplatelet therapy (DAPT) reduces ischemic events but increases bleeding risk, especially in patients with high bleeding risk (HBR). This study aimed to compare outcomes of abbreviated versus standard DAPT strategies in patients with HBR with acute coronary syndrome undergoing percutaneous coronary intervention. METHODS AND RESULTS: Patients from the SWEDEHEART (Swedish Web-syst
Importance: Electroconvulsive therapy (ECT), wherein a generalized epileptic seizure is induced, is a treatment for major depressive disorder (MDD). Currently, it is unclear whether there is an association between seizure length and treatment outcome. Objective: To explore the association between seizure duration, potential confounding variables, and ECT treatment outcome. Design, Setting, and Par
The acoustic hypothesis suggests that schooling can result in several benefits. (1) The acoustic pattern (AP) (pressure waves and other water movements) produced by swimming are likely to serve as signals within fish shoals, communicating useful spatial and temporal information between school members, enabling synchronized locomotion and influencing join, stay or leave decisions and shoal assortme
Impaired rennet coagulation properties in milk could lead to prolonged processing times and production losses. Heritability for milk coagulation has previously been estimated to be 0.28 to 0.45, indicating that genetic selection can be used to manipulate this trait. The CN proteins are expressed by the genes CSN1S1, CSN2, CSN1S2, and CSN3 and are located on bovine chromosome 6. To better understan
Introduction: The potential utility of inflammatory and hemodynamic plasma biomarkers for the prediction of incident lower extremity arterial disease (LEAD), carotid artery stenosis (CAS), isolated atherosclerotic disease without concomitant abdominal aortic aneurysm (AAA), and isolated AAA without concomitant atherosclerotic disease has not yet been integrated in clinical practice. The main objec
This study assesses the potential benefit of Blue-Green Solutions (BGS), green rooftops, rain gardens, permeable pavements, and bioswales, in Lisbon, Portugal. These proposed mitigation measures are applied using TFM-DYN (Nilsson et al., 2021) to simulate potential fluvial flooding distributions from a 10- and 50-year rain event.Water depth of over 30 centimeters can cause damage to infrastructure
(4S)-4-(3-[18F]Fluoropropyl)-L-glutamic acid ([18F]FSPG) is a flourine-18 labeled glutamate analog that enables the noninvasive in vivo imaging of cellular redox status. [18F]FSPG is transported across the cell membrane by the cystine/glutamate antiporter, system xc-, whose expression is upregulated in multiple cancer types. The requirement of cystine for the biosynthesis of glutathione, a major a
Mutations in the NRF2-KEAP1 pathway are common in non-small cell lung cancer (NSCLC) and confer broad-spectrum therapeutic resistance, leading to poor outcomes. The cystine/glutamate antiporter, system xc-, is one of the >200 cytoprotective proteins controlled by NRF2, which can be non-invasively imaged by (S)-4-(3-18F-fluoropropyl)-l-glutamate ([18F]FSPG) positron emission tomography (PET). Throu
