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Recent progress in the field of human induced pluripotent stem cells (iPSCs) has led to the efficient production of human neuronal cell models for in vitro study. This has the potential to enable the understanding of live human cellular and network function which is otherwise not possible. However, a major challenge is the generation of reproducible neural networks together with the ability to int

Purpose: Digital tomosynthesis (DTS) is currently undergoing validation for potential clinical implications. The aim of this study was to investigate the potential for DTS as a low-dose alternative to computed tomography (CT) in imaging of pulmonary pathology in patients with cystic fibrosis (CF). Methods: DTS and CT were performed as part of the routine triannual follow-up in 31 CF patients. Exte

Microsaccades are small fixational eye movements that have shown to index covert attentional shifts. The present experiment combined microsaccades with performance measures from a dot-probe task to study influences of attachment security priming on the attentional biases of individuals high in attachment avoidance. Security priming is an experimental manipulation aimed at boosting felt security. U

Background: According to the “brain-reserve hypothesis” in Alzheimer’s disease (AD), patients with more years of education are expected to have higher cognitive status during adulthood. Hence, they might have a relatively larger burden of AD pathology and a more advanced level of the disease when dementia is clinically evident. Higher educated people would also be expected to perform better on sta

The EPOCH Measure of Adolescent Well-being measures five positive indicators of the well-being of adolescents: engagement, perseverance, optimism, connectedness and happiness. This five-factor structure along with other indicators of validity and reliability were supported for the original English version and the Chinese version. In this study, we tested the psychometric properties of the Swedish

With the widespread transformation of information into digital form through-out society - firms and organisations are embracing this development to adopt multiple types of IT to increase internal efficiency and to achieve external visi-bility and effectiveness - we have now reached a position where there is data in abundance and the challenge is to manage and make use of it fully. This book addres

Background: The function of many orthodontic indices is to assess occlusion in patients born with a cleft. The aim of this study was to assess the intra- and interexaminer reliability for the 5-year-olds' (5YO) index, the GOSLON Yardstick index, and the modified Huddart/Bodenham (MHB) index in dental casts of children with complete unilateral cleft lip and palate (UCLP); a further aim is to compar

Post-acute sequelae of SARS-CoV-2 (PASC), or long COVID syndrome, is emerging as a major health issue in patients with previous SARS-CoV-2 infection. Symptoms commonly experienced by patients include fatigue, palpitations, chest pain, dyspnea, reduced exercise tolerance, and "brain fog". Additionally, symptoms of orthostatic intolerance and syncope suggest the involvement of the autonomic nervous

A composite 11.82 m-long (9876–67 cal yr BP) sediment record from Yellowstone Lake, Wyoming was analyzed using a robust set of biological and geochemical proxies to investigate the paleoenvironmental evolution of the lake and its catchment in response to long-term climate forcing. Oxygen isotopes from diatom frustules were analyzed to reconstruct Holocene climate changes, and pollen, charcoal, dia

Processes underlying changes in the oceanic carbon storage during the Last Glacial Maximum and the subsequent deglaciation are not fully understood. Here, we present a new high-resolution radiocarbon reconstruction (expressed as δ14R) at the depth of the modern Lower Circumpolar Deep Water from the Pacific Sector of the Southern Ocean. Our record shows δ14R increases during Heinrich Stadial 1 and

It has become quite common in environmental sustainability research to promote the influencing of so-called inner dimensions of individuals as means to address pressing environmental problems such as climate change, what we refer to as the Inward Turn. We argue that the conceptual foundations of the Inward Turn, an extreme form of methodological individualism, limit it significantly as a strategy

The surface chemistry and thickness of the native oxide, hydroxide, and modified sub-surface layer of three Ni superalloys (alloy 59, 625, and 718) were determined by synchrotron X-ray Photoelectron Spectroscopy (XPS) and X-ray Reflectivity (XRR). Taking advantage of the synchrotron radiation techniques, a procedure for normalizing the photoelectron intensity was employed, which allowed for accura

Longitudinal coupled-bunch instabilities are driven by monopole higher-order modes (HOMs) in the active and passive radio-frequency (rf) cavities at the MAX IV 3 GeV electron storage ring. By combining different beam and rf-based techniques, we have performed a systematic survey of the properties of these resonant modes as a function of cavity temperatures and fundamental mode frequency. This info

Two-dimensional halide perovskites (2D PVSKs) have drawn tremendous attentions owing to their outstanding ambient stability. However, the random orientation of layered crystals severely impedes the out-of-plane carrier transport and limits the solar cell performance. An in-depth understanding coupled with an effective control of the crystallization in 2D PVSKs is the crux for highly efficient and

In antiferromagnetic spintronics, the read-out of the staggered magnetization or Néel vector is the key obstacle to harnessing the ultra-fast dynamics and stability of antiferromagnets for novel devices. Here, we demonstrate strong exchange coupling of Mn2Au, a unique metallic antiferromagnet that exhibits Néel spin-orbit torques, with thin ferromagnetic Permalloy layers. This allows us to benefit

Periodic shadowing, a concept used in spectroscopy for stray light reduction, has been implemented to improve the temporal contrast of streak camera imaging. The capabilities of this technique are first proven by imaging elastically scattered picosecond laser pulses and are further applied to fluorescence lifetime imaging, where more accurate descriptions of fluorescence decay curves were observed

The search for new interactions and particles in high-energy collider physics relies on precise background predictions. This has led to many advances in combining precise fixed-order cross-section calculations with detailed event generator simulations. In recent years, fixed-order qcd calculations of inclusive cross sections at n3lo precision have emerged, followed by an impressive progress at pro

We construct a three-Higgs doublet model with a flavour non-universal U(1) × ℤ2 symmetry. That symmetry induces suppressed flavour-changing interactions mediated by neutral scalars. New scalars with masses below the TeV scale can still successfully negotiate the constraints arising from flavour data. Such a model can thus encourage direct searches for extra Higgs bosons in the future collider expe