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Computational approaches have been major drivers behind the progress of proteomics in recent years. The aim of this white paper is to provide a framework for integrating computational proteomics into ELIXIR in the near future, and thus to broaden the portfolio of omics technologies supported by this European distributed infrastructure. This white paper is the direct result of a strategy meeting on
Swedish society is characterized by secularization, and at the same time, as a result of migration, the country has become more pluralistic. An important consequence of this is the increasing possibilities for cooperation between different religious communities, and a variety of inter-religious cooperation are currently taking place in Sweden. The aim of the article is to show how inter-religious
Purpose: Transportation systems play a key role in providing individuals with a diversity of means to access their desired destinations and have significant impacts on their quality of life. The social perspective of mobility is, however, marginalized in the current model of transportation planning and significant changes are called for. This study aims to identify the barriers and opportunities o
Structural technologies are an essential component in the design of precision therapeutics. Precision medicine entails the development of therapeutics directed toward a designated target protein, with the goal to deliver the right drug to the right patient at the right time. In the field of oncology, protein structural variants are often associated with oncogenic potential. In a previous proteogen
Glucagon-like peptide-1 (GLP-1) is a gut peptide that regulates food intake and glucose metabolism. GLP-1 is also produced and released in the brain, and GLP-1 receptors are expressed in brain regions important for alcohol and drug reward, and for the development of addiction. GLP-1 receptor agonists can decrease alcohol intake acutely in rodents. However, alcohol use disorder is a chronic conditi
In connection with the Chernobyl fallout and the subsequent deposition of radionuclides in Sweden, Swedish municipalities launched a measurement program to monitor the external radiation exposure. This program encompasses measurements of the ambient dose equivalent rate 1 m above ground at selected locations, and repeats those measurements at the same locations at 7-month intervals. Measurement da
Formal subdivision of the Cambrian System into four series and ten stages is in progress. The base of Cambrian Stage 3 (provisional), which is conterminous with the base of Cambrian Series 2 (provisional), is expected to be placed at a horizon close to the first appearance of trilobites, which marks the onset of the largest phase of the Cambrian explosion. Conceptually, an ideal boundary position
Introduction The spatial peaks QRS-T angle has been shown to differentiate adult patients with hypertrophic cardiomyopathy (HCM) from controls. We hypothesized that the spatial peaks QRS-T angle would, in isolation, be more accurate than the Italian 12-lead ECG Pre-participation Screening criteria or the Seattle criteria for detecting hypertrophic cardiomyopathy (HCM) in pediatric patients. Method
β-1,4-Galactosyltransferase 7 (β4GalT7) is a key enzyme in the biosynthesis of glycosaminoglycan (GAG) chains. Natural and synthetic xylosides can be used to both inhibit and prime GAG synthesis by acting as inhibitors or substrates for β4GalT7. In this report, we exploit hydroxylated oxanes as deoxygenated xyloside analogs to clarify the minimum protein-ligand interactions required for galactosyl
Nuclear hormone receptors (NRs) regulate physiology by sensing lipophilic ligands and adapting cellular transcription appropriately. A growing understanding of the impact of circadian clocks on mammalian transcription has sparked interest in the interregulation of transcriptional programs. Mammalian clocks are based on a transcriptional feedback loop featuring the transcriptional activators circad
The third sector of national innovation systems comprises non-academic, publicly owned R&D organizations that complement universities and private-sector firms and are normally called ‘research institutes’. Scholarly attention to these organizations has been scarce, partly a consequence of the theoretical imbalance in favor of conceptualizations of innovation processes as requiring mainly unive
Pottiaceae subfam. Trichostomoideae in Scania, S Sweden – The members of Pottiaceae subfam. Trichostomoideae excluding Weissia spp. in the province of Skåne (Scania), southern-most Sweden, has been revised based on vouchers collected during the ongoing inventory of the bryophyte flora of the province. In addition, all available earlier records have been compiled and are presented for comparison (b
Key functions of civil society organizations (CSOs) are to criticize governments and to hold them to account. Recent trends of privatization and contracting out challenge CSOs’ opportunities to voice such criticism. The purpose of this article is to analyse whether and why CSOs ‘hold back their criticism’ of public authorities, and how a compromised advocacy can be linked to financial, organizatio
It is a well-institutionalised notion that information subjected to assurance (audit) by third parties contributes to better quality information for decision making. In the field of sustainability reporting, who are providing assurance and how is quality regulated? What are the challenges of regulating sustainability assurance through standards? What role can hard law play to strengthen reporting
Little is presently known about the unique nanostructure of deep eutectic solvents (DES). The order of the liquid-solid phase transition is contended and whether DES-water mixtures are merely aqueous solutions, or have properties dominated by the eutectic pair, is unclear. Here, we unambiguously show the structure of choline chloride-malic acid (malicine) as a liquid, and also in solid and hydrate
We surveyed 110 country churches in south-western Sweden for presence of brown long-eared bats Plecotus auritus in summer 2016 by visual inspection and/or evening emergence counts. Each church was also classified according to the presence and amount of aesthetic directional lights (flood-lights) aimed on its walls and tower from the outside. Sixty-one of the churches had previously been surveyed b
Comprehensive transcriptome studies of cancers often rely on corresponding normal tissue samples to serve as a transcriptional reference. In this study, we performed in-depth analyses of normal kidney tissue transcriptomes from the TCGA and demonstrate that the histological variability in cellularity, inherent in the kidney architecture, lead to considerable transcriptional differences between sam
Enhanced heat transfer tubes (EHTT) with segmented mesh-conical frustums are considered. Tube diameter and frustum apex angle are fixed as 20 mm and 60o, respectively. The height ratio of frustum and sliced part are set as a golden ratio (1.618). Laminar thermal-hydraulic performance and effects of some parameters, e.g., bottom frustum diameter and pitch, are numerically simulated. The equal equiv
