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INTRODUCTION: It is unclear how different proteinopathies (tau, transactive response DNA-binding protein 43 [TDP-43], amyloid β [Aβ], and α-synuclein) contribute to atrophy within medial temporal lobe (MTL) subregions in Alzheimer's disease (AD).METHODS: We utilized antemortem structural magnetic resonance imaging (MRI) data to measure MTL substructures and examined the relative contribution of ta
We demonstrate a successful process scheme for the integration of a CMOS-compatible ferroelectric gate stack on a scaled vertical InAs nanowire gate-all-around MOSFET on silicon. The devices show promising device characteristics with nanosecond write time and large memory window of >1.5 V. In the current implementation, the device performance is mainly limited by access resistance, which is attrib
As a result of recent research discoveries and technological advancements within neuroscience, a growing interest in the brain and its functions permeates not only film studies, but also the field of humanities as a whole. Yet, the neuroscientific influence on contemporary film studies is not easily defined; on the contrary, film scholars with different starting points identify fundamentally diver
This report presents tools for post-occupancy evaluation (POE) to evaluate indoor lighting of commissioned projects (‘case studies’) under a common framework. In this report, POE includes technical environmental assessment (TEA) and observer-based environmental assessment (OBEA). The framework proposed in this report evaluates four key aspects of the case study:1. Energy use (electrical lighting s
This paper focuses on recent debates between the proponents of individualismand communitarianism. As the authors argue, the dichotomous character ofthese debates is inherently problematic, as no one functions just as an individualor member. Starting from the discussion around the Netflix series "Unorthodox"in the Swedish context, the authors engage with Sharon Todd’s radical conception of pluralit
Most creatives acquire professional talents by learning from others, but in most settings it is difficult to estimate the existence of long-term effects. This paper explores the transmission of skills over a period of more than seven centuries by focusing on the case of music composers. We ask the question: how does a composer’s quality influence the quality of the composers he or she teaches? Our
Methylenetetrahydrofolate dehydrogenase/cyclohydrolase (MTHFD2) is a new drug target that is expressed in cancer cells but not in normal adult cells, which provides an Achilles heel to selectively kill cancer cells. Despite the availability of crystal structures of MTHFD2 in the inhibitor- and cofactor-bound forms, key information is missing due to technical limitations, including (a) the location
Sustainability footprints are caused by semiconductor malfunctioning; production challenges (low yield) and customer returns (wear-out). We work with standards, techniques, and methods to quickly and accurately pin-point and mitigate malfunctioning aiming at graceful degradation to prolong operational lifetime.
Denna artikel diskuterar arkivkällor med känslig information och behovet av olika etiska angreppssätt. Avsikten med att lyfta dessa frågor är att frambringa en diskussion om hur historiker kan arbeta med känsligt material på ett etiskt sätt. Artikeln lyfter fram främst tre begrepp: processetik, omsorgsetik och dygdetik.In comparison to disciplines within the humanities and social sciences working directly with living humans, as well as in comparison to oral history, historians primarily working with archival sources lack a living discussion on ethics in connection with our methods. At the same time, archival sources that contain sensitive personal information are central in many fields – such as queer history –
Background: Smoking cessation may be very difficult, even if smoking aggravates the prognosis of a disease, which has been shown to be the case for persons with rheumatoid arthritis (RA). In contrast, an association in patients with osteoarthritis (OA) is still disputed. The primary objective was to compare smokers diagnosed with RA and OA to controls, regarding smoking cessation rates after follo
Introduction: Atopic asthma and allergic rhinitis are common chronic inflammatory diseases affecting lower airways and nasal mucosa, respectively. Several reports demonstrated frequent co-occurrence of these two diseases, however, the exact molecular mechanism has not been described. The present study aimed to investigate if small non-coding RNA might be responsible for the co-occurrence of asthma
Lung transplantion (LTx) recipients have low long-term survival and a high incidence of bronchiolitis obliterans syndrome (BOS), an inflammation of the small airways in chronic rejection of a lung allograft. There is great clinical need for a minimally invasive biomarker of BOS. Here, 644 different proteins were analyzed to detect biomarkers that distinguish BOS grade 0 from grades 1-3. The plasma
