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Sjögren's disease is a complex autoimmune disease with twelve established susceptibility loci. This genome-wide association study (GWAS) identifies ten novel genome-wide significant (GWS) regions in Sjögren's cases of European ancestry: CD247, NAB1, PTTG1-MIR146A, PRDM1-ATG5, TNFAIP3, XKR6, MAPT-CRHR1, RPTOR-CHMP6-BAIAP6, TYK2, SYNGR1. Polygenic risk scores yield predictability (AUROC = 0.71) and

När Svenska kyrkan, den gamla lutherska statliga institutionen för tro och tillhörighet, ges ny inramning i ett välfärdssamhälle som förändras – förändras då även bilden av kyrkans sociala ansvarstagande?I detta kapitel är ambitionen att beskriva Svenska kyrkans roll i förhållande först till ”välfärdsstaten” och sedan till den välfärdsmix eller den ”välfärdspluralism” som präglar förhållandena ida

I dagens välfärdspluralism antar idéburna organisationer roller som gemenskapsbyggare, röstbärare och serviceleverantörer. Det socialpolitiska landskapet är under ständig förändring – något som påverkar kyrkan och dess diakonala arbete. I kyrklig diakoni ryms praktik och reflektion, teologisk och socialpolitisk. Hur gestaltas detta? Vilka verksamheter prioriteras, hur organiseras och leds det diak

Att rapportera resultat ser de flesta i dagens samhälle som en självklar plikt. Många offentligfinansierade verksamheter styrs enligt en marknadslogik som bygger på kontraktsbaserade uppdrag som bland annat innebär en granskning av hur skattemedlen används. Redovisning sker genom mer eller mindre ingående kontroll med syftet att säkra den kvalitet man beställt och att visa att eftersträvade result

BACKGROUND: The widespread use of intramedullary nails (IMNs) compared with sliding hip screws (SHSs) in extracapsular hip fractures (AO/OTA 31-A1, 31-A2, 31-A3) has been questioned because of a higher complication rate, although the outcome might have improved through more recent implant designs and the learning curve. This study aimed to investigate if there is a difference with regard to the cu

Vocabulary experts recommend first language (L1) translation equivalents for establishing form–meaning mappings for new second language (L2) words, especially for lower proficiency learners. Empirical evidence to date speaks in favor of L1 translation equivalents over L2 meaning definitions, but most studies have investigated bi- rather than multilingual learners. In our study, we investigated ins

Individuals with obsessive-compulsive disorder (OCD) more often think about, attempt, and die by suicide than individuals from the general population. Sexual and religious obsessions (i.e., taboo obsessions) have been linked to increased risk of suicidality, but it is unclear if they explain additional risk over and above other risk factors. We refined the recently proposed multidimensional hierar

It is commonly assumed that algorithmic curation of search results creates filter bubbles, where users’ beliefs are continually reinforced and opposing views are suppressed. However, empirical evidence has failed to support this hypothesis. Instead, it has been suggested that filter bubbles may result from individuals engaging selectively with information in search engine results pages. However, t

BackgroundPrioritizing the maintenance of healthy cognitive aging and personalizing preventive interventions to enhance their effectiveness is crucial as the global population ages. Systemic inflammation and depression in older people have been associated with decreased levels of cognition but results have been inconsistent.AimsTo explore the interactive network of inflammation, depression and cog

Background: Growth differentiation factor 15 (GDF-15) has been associated with the risk of developing major bleedings, including but not restricted to intracranial hemorrhages, in patients on oral anticoagulants or dual antiplatelet therapy. We hypothesized that there may be an association of GDF-15 with incidence of hemorrhagic strokes in the general population, which has not been investigated be

Background: There has been a global increase in the number of people who are dying of old age. This development implies a need for good palliative care among older persons at the end of life. Here nursing homes have an important role to play. However, the principles of palliative care have not been sufficiently applied in nursing homes, and there is a need to increase the implementation of palliat

Review of Anna-Maija Multas PhD thesis from 2022: New health information literacies. A nexus analytical study. Acta universitatis OuluensisB Humaniora 192, University of Oulu, Oulu