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The extracellular matrix provides a solid scaffold and signals to cells through extracellular matrix receptors. The cell-matrix interactions are crucial for normal biological processes and when disrupted they may lead to pathological processes. In particular, the biological importance of extracellular matrix-cell membrane-cytoskeleton interactions in skeletal muscle is accentuated by the number of
The interaction between UV-B irradiation and cutaneous human papillomaviruses (HPV) has been suggested to be of relevance for the development of non-melanoma skin cancers. We investigated the activity within the upstream regulatory region (URR) of the HPV types 8, 38, 92, 93 and 96, as well as their responsiveness to UV-B irradiation and cellular differentiation. Promoter activities were higher in
Knowledge concerning professionals involved in dementia care throughout its trajectory is sparse; the focus has mainly been on nursing-home care and less on home care, diagnosis and treatment of the disease and its complications despite the fact that home care is the most prominent type of care. The aim of this study was to explore and describe professional care providers involved in dementia care
Cardio-cerebrovascular diseases are key factors causing recipient the death after kidney transplantation (KT). Hypertriglyceridemia (HTG), a complication commonly occurring among KT patients, is a major risk factor for cardio-cerebrovascular diseases. The objective of this study was to examine the correlation between peripheral CD14+CD16++ monocytes in KT patients and blood lipids as well as facto
Endometrial cancer generally has a good prognosis because most cases are diagnosed in stage I. It is possible to identify subgroups of patients with early stage endometrial cancer with a poor prognosis. Despite a traditional generous use of adjuvant radiotherapy those patients have less than an 80% 5-year overall survival. In this group there is a need for an effective systemic adjuvant therapy. T
Dyskinesia seen in the off-state, referred as graft-induced dyskinesia (GID), has emerged as a serious complication induced by dopamine (DA) cell transplantation in parkinsonian patients. Although the mechanism underlying the appearance of GID is unknown, in a recent clinical study the partial 5-HT(1A) agonist buspirone was found to markedly reduce GID in three grafted patients, who showed signifi
Patient safety is an important global issue. While it is well known that patients can suffer from adverse events in nursing care, there is a lack of knowledge as to how they experience them.
BACKGROUND:: Microvascular injury and epithelial barrier dysfunction are rate-limiting aspects in radiation enteropathy. This study examined the role of p38 mitogen-activated protein kinase (p38 MAPK) signalling in radiation-induced colitis in an experimental model. METHODS:: The p38 MAPK inhibitor SB239063 was administered to mice immediately before exposure to 20 Gy radiation. Leucocyte- and pla
The objective of this study was to investigate the possible association between mitochondrial DNA polymorphisms and systemic lupus erythematosus (SLE). A cohort from the Department of Rheumatology, Lund University Hospital, Sweden, consisting of 166 unrelated SLE patients was investigated as well as 190 unrelated healthy blood donors. Mean age at SLE diagnosis was 39 years (range 10-83) and mean f
Systematic multiconfiguration Hartree-Fock results are presented for the transition probabilities and excited-state lifetimes in the term system of the boron atom. Particularly, the interaction between the 1s(2)2s2p2 configuration and the 1s(2)2s2ns2S and 1s(2)2s2nd2D Rydberg series is considered. Term energies and transition-matrix elements are calculated to convergence using increasing active se
Objective:To investigate the prevalence and the secular trends of obesity in a rural Swedish community with emphasis on the association with socioeconomic status and lifestyle.Design:The Skaraborg Project cross-sectional population surveys were conducted in Vara, a rural community in the southwest of Sweden, every fifth year between 1977 and 2002.Subjects:A total of 3365 residents (1634 men and 17
We present a compact, fast, and versatile fiber-optic probe system for real-time determination of tissue optical properties from spatially resolved continuous-wave diffuse reflectance measurements. The system collects one set of reflectance data from six source-detector distances at four arbitrary wavelengths with a maximum overall sampling rate of 100 Hz. Multivariate calibration techniques based
Purpose: We aimed to compare the retinal nerve fibre layer (RNFL) in different Stratus optical coherence tomography (OCT) images in glaucoma eyes with RNFL thickness values within normal limits. Methods: We studied the Stratus OCT high-resolution standard protocol for assessment of peripapillary RNFL thickness. The four glaucoma eyes presented (with reproducible visual field defects, mean deviatio
We investigated the possible consequences of two consecutive postural tasks on adaptation. Four groups (total number of 46 healthy subjects) were perturbed on two consecutive days with vibration stimulus to tibialis anterior or posterior calf muscles, or both in different orders. Postural movements were recorded with a force platform. There were three major results: (1) tibialis anterior vibration
We present a theoretical study of high-order harmonic generation by a slowly driven ''Duffing'' anharmonic oscillator. The power spectra are shown to display a plateau of high harmonics, which ends up with a sharp cutoff. The classical dynamics is analyzed with the adiabatic invariance theorem, which yields a simple interpretation to this characteristic behavior. We compare with the quantum case b
Purpose - The purpose of this paper is to investigate a strategic change from parallel cell-based assembly (old) to serial-line assembly (new) in a Swedish company with special reference to how production system design elements affect both productivity and ergonomics. Design/methodology/approach - Multiple methods, including records and video analysis, questionnaires, interviews, biomechanical mod
Resource use and costs for topical treatment of hard-to-heal ulcers based on data from the Swedish Registry of Ulcer Treatment (RUT) were analysed in patients recorded in RUT as having healed between 2009 and 2012, in order to estimate potential cost savings from reductions in frequency of dressing changes and healing times. RUT is used to capture areas of improvement in ulcer care and to enable s
