Breast tumors of the basal-like, hormone receptor-negative subtype remain an unmet clinical challenge, as there is high rate of recurrence and poor survival in patients following treatment. Coevolution of the malignant mammary epithelium and its underlying stroma instigates cancer-associated fibroblasts (CAFs) to support most, if not all, hallmarks of cancer progression. Here we delineate a previo

Measurements of ZZ production in the +-′+′- channel in proton-proton collisions at 13 TeV center-of-mass energy at the Large Hadron Collider are presented. The data correspond to 36.1 fb-1 of collisions collected by the ATLAS experiment in 2015 and 2016. Here and ′ stand for electrons or muons. Integrated and differential ZZ→+-′+′- cross sections with Z→+- candidate masses in the range of 66 GeV t

When using fluorescence microscope techniques to study cells, it is essential that the cell structure and contents are preserved after preparation of the samples, and that the preparation method employed does not create artefacts that can be perceived as cellular structure/components. γ-Tubulin forms filaments that in some cases are immunostained with an anti-γ-tubulin antibody, but this immunosta

Purpose: The purpose of this paper is to explore how the notion of “relevance” is produced, distributed and consumed in the field of management research by applying a critical discourse analysis (CDA) as a theoretical lens. A CDA perspective offers a way to scrutinize the power relations that emerge with journal rankings and how these influence how the relevance discourse develops. Design/methodol

We investigated the pragmatic effects of gesture-speech lag by asking participants to reconstruct formations of geometric shapes based on instructional films in four conditions: sync, video or audio lag (±1,500 ms), audio only. All three video groups rated the task as less difficult compared to the audio-only group and performed better. The scores were slightly lower when sound preceded gestures (

This paper studies the role of imported inputs in explaining firms’ export behaviour. Unlike most of the existing literature we are also able to control for the participation of domestic firms to multinational networks. This allows us to test to what extent the recurrent evidence that importing foster exporting activity is instead a figment of the fact that importers are also part of multinational

Bacterial strains were isolated from the sediments of the Baltic Sea using ferulic acid, guaiacol or a lignin-rich softwood waste stream as substrate. In total nine isolates were obtained, five on ferulic acid, two on guaiacol and two on a lignin-rich softwood stream as a carbon source. Three of the isolates were found to be Pseudomonas sp. based on 16S rRNA sequencing. Among them, isolate 9.1, wh

Mantle cell lymphoma (MCL) is associated with poor prognosis due to an aggressive clinical course. Being a raredisease, there are few randomized trials in MCL and there is no defined golden standard in primary treatment.This works aimed to (I) investigate outcome in relation to primary treatment in MCL based on population-basedregistry data, (II) to evaluate tolerability and efficacy of lenalidomiMantle cell lymphoma (MCL) is associated with poor prognosis due to an aggressive clinical course. Being a rare disease, there are few randomized trials in MCL and there is no defined golden standard in primary treatment. This works aimed to (I) investigate outcome in relation to primary treatment in MCL based on population-based registry data, (II) to evaluate tolerability and efficacy of lenalid

In the last years the use of information communication technologies (ICTs) has become a leading driver of OECD national health systems to improve healthcare quality and reduce healthcare costs (Oecd, 2010). In fact, the use of ICTs are a primary lever of OECD countries to enhance the efficiency and the effectiveness of health services delivered to the citizens. This has led the Italian government In the last years the use of information communication technologies (ICTs) has become a leading driver of OECD national health systems to improve healthcare quality and reduce healthcare costs (Oecd, 2010). In fact, the use of ICTs are a primary lever of OECD countries to enhance the efficiency and the effectiveness of health services delivered to the citizens. This has led the Italian government

One example of the welfare state’s health ambitions is to reduce the onset of illness and mortality from cancer, which among other things means that approximately 900,000 women in Sweden in the age group 40–74 years recurrently receive an invitation to mammography screening. The objective is to detect possible breast cancer at an early stage and thereby reduce mortality from the disease. For this

Much of identity formation processes nowadays takes place online, indicating that intergroup differentiation may be found in online communities. This paper focuses on identity formation processes in an open online xenophobic, anti-immigrant, discussion forum. Open discussion forums provide an excellent opportunity to investigate open interactions that may reveal how identity is formed and how indi

An experimental study has been carried out to investigate the effects of Coriolis force and centrifugal buoyancy force on convective heat transfer in a smooth cooling channel under rotating condition in a new rotation facility. The main motivation behind this work is to obtain required data for developing heat transfer correlations based on rotating state. In accordance with the open literature, f

Remodeling of the extracellular matrix (ECM) is a common feature in lung diseases such as chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF). Here, we applied a sequential tissue extraction strategy to describe disease-specific remodeling of human lung tissue in disease, using end-stages of COPD and IPF. Our strategy was based on quantitative comparison of the dis

Muscular dystrophies, including laminin α2 chain-deficient muscular dystrophy (LAMA2-CMD), are associated with immense personal, social and economic burdens. Thus, effective treatments are urgently needed. LAMA2-CMD is either a severe, early-onset condition with complete laminin α2 chain-deficiency or a milder, late-onset form with partial laminin α2 chain-deficiency. Mouse models dy 3K /dy 3K

The Sendai Framework for Disaster Risk Reduction highlights the importance of all-hazard and multi-stakeholder approaches. This requires exchange and integration of risk information across sectorial and administrative borders. This paper focuses on challenges and prerequisites for aggregating risk information from multiple stakeholders in disaster risk management systems. Aggregation is here under

We present a novel computational technique intended for the robust and adaptable control of a multifunctional prosthetic hand using multichannel surface electromyography. The initial processing of the input data was oriented towards extracting relevant time domain features of the EMG signal. Following the feature calculation, a piecewise modeling of the multidimensional EMG feature dynamics using

Socioeconomic, ethnic and gender disparities in Chronic Obstructive Pulmonary Disease (COPD) risk are well established but no studies have applied multilevel analysis of individual heterogeneity and discriminatory accuracy (MAIHDA) within an intersectional framework to study this outcome. We study individuals at the first level of analysis and combinations of multiple social and demographic catego