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What the world has seen since the atrocious terrorist attacks of 11 September 2001, and the counter-terrorism measures states have taken by way of their response, can be characterised as the worst-ever backlash against the promotion and protection of human rights since their post-Second World War emergence in the UN Charter (1945) and the Universal Declaration of Human Rights (UDHR, 1948). In this
Dust burden during the dust storms events imparts an adverse effect on human health and environment. The aim of this research is to provide a deeper understanding about the atmospheric dynamics of long-range transport of mineral dust for 8 severe dust storm events over the Indian region during the period 2008–2022. Transport of mineral dust analyzed based on MERRA-2 Dust column mass density, follo
Heatwaves are becoming more intense, frequent, and prolonged due to global warming, posing significant risks to ecosystems and human societies. Despite their profound impact, detailed regional assessments of extreme heat events remain limited, particularly in India. This study addresses the gap by systematically investigating the 2024 extreme heat event in India. We evaluated the performance of va
BackgroundCerebral small vessel disease (CSVD) is one of the most important causes of cognitive decline. Only a few previous studies have evaluated lung function measures in relation to brain neuropathological changes, and even less studies on specific lesions and areas that could shed light on mechanisms of CSVD.ObjectiveThe aim was to study the association between lung function and CSVD in the g
Almost seven million Ukrainians have fled Ukraine since Russia’s large-scale invasion in February 2022. Seeking refuge in other European states, they were welcomed. However, recent analyses have emerged which point to an increasing discrimination against Ukrainian refugees who were displaced by Russia’s aggression, including in previously supportive nations like Poland. The shifting treatment and
AimsAdipose tissue distribution, metabolism, and expansion capacity exhibit notable sex- and depot-specific differences. Herein, we monitored adipocyte traits related to insulin responsiveness and glucose transport during adipose expansion in visceral and subcutaneous fat from male and female mice.Material and methodsAdipocytes were isolated from perigonadal and inguinal adipose tissue of chow-fed
ABSTRACT Intact insulin signaling and glucose transport in adipocytes are crucial to maintaining whole-body energy metabolism. Focal adhesion kinase stands as a central intracellular protein facilitating signaling between the extracellular matrix and the cytoplasm, thereby regulating cellular metabolism. Here, we have investigated the role of focal adhesion kinase in adipocyte glucose transport us
Knowledge of animal diets is fundamental in ecology as it can provide insight into the structure, function and resilience of entire ecosystems. In this study we investigate the diet composition of the harbour porpoise (Phocoena phocoena), a small marine top predator with great ecological importance, to provide updated dietary estimates for the species in Swedish waters. This is done by parallel us
Objective:The aim of this study was to investigate sensorimotor functions that require cerebellar processing, and visuospatial perception and visuospatial abilities in adult patients with attention deficit hyperactivity disorder (ADHD) and autism spectrum disorder (ASD).Method:We included patients with unmedicated ADHD (n = 52), medicated ADHD (n = 39), ASD (n = 33), the combination of unmedicated
Årets Arena Idé-rapport om den svenska modellen och organisations-graden hos fack, arbetsgivare och a-kassor innehåller de senaste medlemsuppgifterna för samtliga fackförbund inklusive förbunden utanför LO, TCO och Saco. Det gäller antalet yrkesaktiva medlemmar vid årsskiftet 2024/2025. Även medlemsutvecklingen i PTK och OFR redovisas avseende de medlemmar som räknas till respektive förhandlingsor
Recently, it has become a focus to reduce non-exhaust aerosol emissions from the transport sector. One possible way to decrease brake particle emissions is by laser-cladding coatings onto brake discs. This work tested five different laser-cladding coated brake discs against a non-asbestos organic brake pad. The performance of these coatings was compared to a commercial grey cast iron brake disc te
Introduction: Severe asthma is a heterogeneous condition characterized bydistinct phenotypes and endotypes based on clinical or biologicalcharacteristics. Interleukin (IL) 4 and IL-13 are central cytokines in the type 2(T2) immune response, crucial for T2 inflammation. Biologic therapiestargeting the IL-4/IL-13 pathway, such as anti-IL-4Rα monoclonal antibodies(mAbs), have shown improvements in luIntroduction: Severe asthma is a heterogeneous condition characterized by distinct phenotypes and endotypes based on clinical or biological characteristics. Interleukin (IL) 4 and IL-13 are central cytokines in the type 2 (T2) immune response, crucial for T2 inflammation. Biologic therapies targeting the IL-4/IL-13 pathway, such as anti-IL-4Rα monoclonal antibodies (mAbs), have shown improvements
Background Anti-interleukin (IL)-4Rα monoclonal antibodies (mAb) improve lung function and decreasethe number of exacerbations in patients with COPD type (T) 2 inflammation. However, the involvement ofearly innate immune responses underlying these treatment effects is not well known. We sought tounderstand the effect and mechanisms of IL-4Rα mAb treatment on bronchial epithelial cells (BECs) fromCBackgroundAnti-IL-4Rα monoclonal antibodies (mAb) improve lung function and decrease the number of exacerbations in patients with COPD type (T) 2 inflammation. However, the involvement of early innate immune responses underlying these treatment effects is not well known. We sought to understand the effect and mechanisms of IL-4Rα mAb treatment on bronchial epithelial cells from COPD patients under
