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Globally, the lifespan of populations increases but the healthspan is lagging behind. Previous research showed that survival into extreme ages (longevity) clusters in families as illustrated by the increasing lifespan of study participants with each additional long-lived family member. Here we investigate whether the healthspan in such families follows a similar quantitative pattern using three-ge

Chronic lymphocytic leukemia (CLL) is the most common leukemia among adults worldwide. Although genome-wide association studies (GWAS) have uncovered the germline genetic component underlying CLL susceptibility, the potential use of GWAS-identified risk variants to predict disease progression and patient survival remains unexplored. Here, we evaluated whether 41 GWAS-identified risk variants for C

OBJECTIVE: Traditionally, the diagnosis of pleural mesothelioma is based on histological material. Minimally invasive effusion cytology specimens are an alternative that, like biopsies, require ancillary analyses. Validation of immunohistochemical (IHC) analyses on cytology, including the surrogate markers for molecular alterations BAP1 and MTAP, is of interest.METHODS: IHC for eight different mar

In this paper, a comparative study of core losses in laminated steel samples by means of inferential statistics is presented. In particular, core loss measurements taken upon Epstein Frame, Single-Strip tester, and Ring Core specimens at several frequencies and induction levels are compared via Analysis of Variance and two-sample t-tests. The hypothesis of a statistically significant difference am

Durability and service life assessment is a major challenge for the design and use of timber in outdoor weather exposed environments. Rate of deterioration by fungal decay is closely linked to variations in wood moisture content. The objective of the present paper is to test and evaluate different data-driven models based on the multilinear regression (MLR) and artificial neural network (ANN) appr

Ventricular-arterial coupling (VAC) has independent diagnostic and prognostic value for cardiovascular (CV) risk stratification, but studies on its association with anthropometric and CV factors are sparse in young individuals without overt CV disease. We aim to provide descriptive data regarding VAC and its associations with CV risk factors in young adults without overt CV disease. For 631 (mean

PURPOSE: Absent lymph flow and chronic inflammationleads to excess subcutaneous adipose tissue deposition.Chronic non-pitting lymphedema does not respond to conservativetreatment or microsurgical procedures becausethey do not target the adipose tissue. Removing the adiposetissue using suction assisted lipectomy (SAL) seems thus tobe a logic treatment strategy.METHODS: Arms: 190 women, mean±SEM age

The continuous increase in global energy consumption has led to a greater focus on the energy required for heating buildings. This thesis presents a techno-economic model for analysing low-temperature district heating networks coupled with a geothermal heat source. The model was used to analyse an existing system in Denmark with 15 connected single-family detached houses. Each of the houses has a

BackgroundHepatitis B virus (HBV) and syphilis have been the most common co-infections that hinder treatment outcomes and increase early mortality among people living with human immunodeficiency virus (PLHIV). In this study, we aimed to determine the burden of HBV and syphilis co-infections and its impact on treatment outcomes among PLHIV in Ethiopia.MethodsWe used data from the Ethiopian Populati

It has been shown that ultra-high frequency (UHF) ultrasound applied to the external bowel wall can delineate the histo-anatomic layers in detail and distinguish normal bowel from aganglionosis. This would potentially reduce or lessen the need for biopsies that are currently mandatory for the diagnosis of Hirschsprung’s disease. However, to our knowledge, no suitable rectal probes for such a use a

Background: Optimizing rectal suction biopsy (RSB) diagnostics in Hirschsprung’s disease (HD) may shorten diagnostic time and prevent need for repeated biopsies. Aim: To explore whether systematic orientation of fresh RSB specimens increased biopsy quality, diagnostic times, diagnostic efficacy, and histopathologic workload, and to explore these outcome measures for aganglionic specimens. Material

Hirschsprung’s disease (HD) is characterized by aganglionosis in the bowel wall, requiring resection. Ultra-high frequency ultrasound (UHFUS) imaging of the bowel wall has been suggested to be an instantaneous method of deciding resection length. The aim of this study was to validate UHFUS imaging of the bowel wall in children with HD by exploring the correlation and systematic differences between

Gruppundervisning sprids snabbt över världen, men lite forskning har utförts för att undersöka dess inverkan på elevers musikaliska förmågor jämfört med inkludering i gruppundervisningssammanhang. Den här artikeln undersöker hur musiklärare från den klassiska orkesterinstrumentala traditionen diskuterar gruppundervisning. Tre fokusgruppsintervjuer genomfördes med deltagare från en kulturskola i SvGroup teaching is rapidly spreading across the world, but little research has been conducted to investigate its impact on students’ musical abilities in comparison to inclusion in group tuition contexts. This article investigates how music teachers from the classical orchestra instrumental tradition discuss group tuition. Three focus group interviews were conducted with participants from one Art a

Stupidity is generally thought of as a hindrance to learning: an epistemic vice that stands in the way of knowledge and understanding. In this article, I challenge this idea by exploring some of the meanings of stupidity that place it in a positive relation to learning. In this light, the article discusses two notions of stupidity: stupidity as unfinished thought and stupefaction through study. I

The building sector is facing a challenge in achieving carbon neutrality due to climate change and urbanization. Urban building energy modeling (UBEM) is an effective method to understand the energy use of building stocks at an urban scale and evaluate retrofit scenarios against future weather variations, supporting the implementation of carbon emission reduction policies. Currently, most studies

Objective This study assessed the magnitude of risky sexual practices and associated factors among adult people living with HIV (PLHIV) attending antiretroviral clinics in public hospitals in Kembata Tembaro Zone, southern Ethiopia.Design A cross-sectional study was conducted.Setting A hospital-based study was conducted among adult PLHIV in the Kambata Tambaro Zone, southern Ethiopia.Participants