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Background: Oral contraceptive use has been associated with an increase in the risk of breast cancer in young women. We examined whether this association is seen in women at high risk of breast cancer because they carry a mutation in one of two breast cancer susceptibility genes, BRCA1 and BRCA2. Methods: We performed a matched case-control study on 1311 pairs of women with known deleterious BRCA1
Neuroinformatics is the information science infrastructure of neuroscience. It relates to the tools, databases, models and mechanisms of information flow that serve all of the clinical and research efforts in this field. There have been several attempts to create neuroinformatic systems, but none seem to have reached wide spread adoption yet. This is especially true in the in the area of cognitive
Popular Abstract in Swedish Det är väl känt att äldre lever med långvarig smärta, särskilt från rörelseapparaten. Det är dock ovanligare att de allra äldsta och de äldre, som bor i särskilt boende alternativt får hjälp i det ordinära boendet, inkluderas i olika studier. Det är också mindre väl undersökt i vilken omfattning smärta samvarierar med andra problem och hur den påverkar livskvaliteten, sThe overall aim was to investigate chronic pain, quality of life and factors associated with pain as well as with quality of life among older people, aged 75 years and above. Further, the aim was to investigate the use of methods for pain management and their effects for those with pain and in need of help for daily living. Data were collected from a larger population study and in the first study
Photoinduced Ba L x-rays were measured, in the excitation energy range of 5.6-30 keV, by using high-brilliance undulator radiation. The obtained intensity ratios, the excitation-energy independent L beta(4)/L beta(3), L eta/L beta(1), L iota/L alpha(1,2), L beta(6)/ L alpha(1,2) and L beta(2,15)/L alpha(1,2) as well as the excitation- energy dependent L beta(1)/L alpha(1,2), L beta(3)/L alpha(1,2)
Popular Abstract in Swedish Missbrukande kvinnor och mammor har ofta fördömts av samhället och av människor i sin omgivning. De har setts som ansvarslösa kvinnor och olämpliga mammor utifrån en samhällssyn, att barn och missbruk inte går ihop. De livshistoriska intervjuerna med missbrukande kvinnor och mammor, som avhandlingen bygger på visar, att kvinnorna både vill vara respektabla och ta väl haThe aim of the dissertation is to describe the conditions under which substance abusing women live with regard to their families, the substance abuse and treatment. The interaction between the substance abusing women and the institutional expectations is analysed from gender and class perspective. The dissertation is based on interviews with two groups of substance abusing women: 12 mothers, livin
Akylphenols (4-nonylphenol, 4-(1,1,3,3-tetramethylbutyl)-phenol and 2,6-bis(1,1-dimethylethyl)-4-ethylphenol) have been directly extracted from water samples using neat supercritical carbon dioxide and collected on an octadecyl silica (ODS) solid phase trap. The extraction cells were equipped with home-built assemblies containing hydrophobic membranes. The assemblies were inserted at each end of t
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Glutathione peroxidase (GSHPx) activity, and total and soluble selenium content were compared in five bovine and porcine organs. The highest GSHPx activity in porcine tissues was found in the liver (35.0 U/g), spleen (29.3 U/g) and kidney (27.3 U/g) with much lower values in the heart (1.8 U/g) and diaphragm (0.8 U/g). A different pattern with lower inter-organ variation in GSHPx activity was obse
Nitric oxide (NO)/cyclic GMP (cGMP)-mediated mechanisms have a pivotal function in reducing the tone of the penile smooth musculature during normal erectile responses. The cyclic AMP ( cAMP) signaling pathway is also involved in the adjustment of smooth muscle contractility, and suggestions for interactions between cGMP- and cAMP-mediated mechanisms have been presented. Using activators of the cGM
Phosphodiesterase type 3B (PDE3B) has been shown to be activated and phosphorylated in response to insulin and hormones that increase cAMP. In order to study serine/threonine protein phosphatases involved in the regulation of rat adipocyte PDE3B, we investigated the phosphorylation and activation of PDE3B in vivo in response to phosphatase inhibitors and the dephosphorylation and deactivation of P
The scalar polarizability constanta0 for excitedS- andD-states in rubidium and cesium was measured utilizing a two-step excitation scheme. An rf lamp and a single-mode dye laser were used to excite the atoms in a collimated atomic beam. Values ofa0 were determined for the 9–102S1/2 and 7–82D3/2 states of rubidium and for the 10–132S1/2, 9–102D3/2 and 9–112D5/2 states of cesium. Further, the isotop
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An extensive research program on combustible wall lining materials has been carried out in Sweden. Several lining materials were tested in full scale room tests and 1/3 scale model room tests for two different scenarios, A and B. Scenario A refers to the case where walls and ceiling are covered by the lining material, scenario B where lining materials are mounted on walls only. A model is presente
