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Ventricular-arterial coupling : definition, pathophysiology and therapeutic targets in cardiovascular disease

Introduction: The heart and arterial system are equally affected by arteriosclerosis/atherosclerosis. There is a constant interaction between the left ventricular (LV) function and the arterial system, termed ventricular-arterial coupling (VAC), which reflects the global cardiovascular efficiency. VAC is traditionally assessed by echocardiography as the ratio of effective arterial elastance (Ea) o

Sharp asymptotic estimates for a class of Littlewood-Paley operators

It is well-known that Littlewood-Paley operators formed with respect to lacunary sets of finite order are bounded on Lp(ℝ) for all 1 < p < ∞. In this note it is shown that 'Equation Presented' where SIE2 denotes the classical Littlewood-Paley operator formed with respect to the second order lacunary set E2 = {±(2k -2l) : k, l ∈ ℤ with k > l}. Variants in the periodic setting and for certain lacuna

Risk of incident fractures in individuals hospitalised due to unexplained syncope and orthostatic hypotension

Background Impaired orthostatic blood pressure response and syncope confer a high risk of falls and trauma. The relationship between a history of unexplained syncope and orthostatic hypotension (OH) with subsequent fractures, however, has not been thoroughly examined. In this study, we aimed to investigate the relationship between previous hospital admissions due to unexplained syncope and OH and

Ice out of Fire : Ice and cloud condensation nucleation of aerosol particles emitted from controlled soot generation and combustion of renewable fuels

Aerosol particles, small solid or liquid particles suspended in a gas, are found everywhere in the atmosphere. Air pollution from such particles, mainly soot from combustion-derived activity is a leading cause of premature deaths in the world and have a large effect on the climate. Aerosol particles can interact with climate-related processes in the atmosphere either directly by absorbing or refle

Efficacy and Safety of Umeclidinium/Vilanterol in Current and Former Smokers with COPD : A Prespecified Analysis of The EMAX Trial

Introduction: Smoking may reduce the efficacy of inhaled corticosteroids (ICS) in patients with chronic obstructive pulmonary disease (COPD), but its impact on bronchodilator efficacy is unclear. This analysis of the EMAX trial explored efficacy and safety of dual- versus mono-bronchodilator therapy in current or former smokers with COPD. Methods: The 24-week EMAX trial evaluated lung function, sy

Determinants for use of direct-to-consumer telemedicine consultations in primary healthcare-a registry based total population study from Stockholm, Sweden

BACKGROUND: In recent years, telemedicine consultations have evolved as a new form of providing primary healthcare. Telemedicine options can provide benefits to patients in terms of access, reduced travel time and no risk of disease spreading. However, concerns have been raised that access is not equally distributed in the population, which could lead to increased inequality in health. The aim of

Evaluation of Feasibility of High-Power Long-Pulse Transformers Using Single-Layer and Pancake Winding Techniques

Solid-state klystron modulators are typically based on oil-immersed high-voltage (HV) pulse transformers because of their high performance, robustness, simplicity, and straightforward design. However, pulse transformer size is fundamentally linked to application pulse length, pulse power, and pulse rise time. For high-power applications transformer size quickly becomes very problematic when approa

The effect of ph and storage temperature on the stability of emulsions stabilized by rapeseed proteins

Rapeseed press cake (RPC), the by-product of rapeseed oil production, contains proteins with emulsifying properties, which can be used in food applications. Proteins from industrially produced RPC were extracted at pH 10.5 and precipitated at pH 3 (RPP3) and 6.5 (RPP6.5). Emulsions were formulated at three different pHs (pH 3, 4.5, and 6) with soy lecithin as control, and were stored for six month

Living with relatives offsets the harm caused by pathogens in natural populations

Living with relatives can be highly beneficial, enhancing reproduction and survival. High relatedness can, however, increase susceptibility to pathogens. Here, we examine whether the benefits of living with relatives offset the harm caused by pathogens, and if this depends on whether species typically live with kin. Using comparative meta-analysis of plants, animals, and a bacterium (nspecies = 56

Host tropism determination by convergent evolution of immunological evasion in the Lyme disease system

Pathogens possess the ability to adapt and survive in some host species but not in others–an ecological trait known as host tropism. Transmitted through ticks and carried mainly by mammals and birds, the Lyme disease (LD) bacterium is a well-suited model to study such tropism. Three main causative agents of LD, Borrelia burgdorferi, B. afzelii, and B. garinii, vary in host ranges through mechanism

Spatial variation in scent emission within flowers

Floral scent is considered an important long-distance signal that attracts pollinators, but also has been suggested to function at shorter distances such as within-flower nectar guides or as a defense against antagonists. Indeed, in some species floral scent production and emission show spatial patterns of variation within flowers, as certain compounds are exclusively emitted from specific floral

Methodology and applicability of the human contact burn injury model : A systematic review

The contact burn injury model is an experimental contact thermode-based physiological pain model primarily applied in research of drug efficacy in humans. The employment of the contact burn injury model across studies has been inconsistent regarding essential methodological variables, challenging the validity of the model. This systematic review analyzes methodologies, outcomes, and research appli

Targeting Oncogenic WNT Signalling with WNT Signalling-Derived Peptides

WNT signalling is known to be a crucial regulator of embryonic development and tissue homeostasis. Aberrant expression of WNT signalling elements or their mutations has been implicated in carcinogenesis and/or the progression of several different cancer types. Investigations of how WNT signalling affects carcinogenesis and cancer progression have revealed that it has essential roles in the regulat

Stratigraphic Relationships in Jezero Crater, Mars : Constraints on the Timing of Fluvial-Lacustrine Activity From Orbital Observations

On February 18, 2021 NASA's Perseverance rover landed in Jezero crater, located at the northwestern edge of the Isidis basin on Mars. The uppermost surface of the present-day crater floor is dominated by a distinct geologic assemblage previously referred to as the dark-toned floor. It consists of a smooth, dark-toned unit overlying and variably covering light-toned, roughly eroded deposits showing

Bikini textile contact dermatitis : A Sherlockian approach revealing 2.4-dichlorophenol as a potential textile contact allergen

Background: Different textile constituents may act as allergens and/or irritants and provoke textile contact dermatitis (TCD). Objectives: To report a case of TCD caused by ethylene glycol monododecyl ether and 2.4-dichlorophenol, present in a bikini. Methods: A woman presented with an eczematous, pruritic rash in the area of the bikini straps and back. Patch testing was performed with the Europea