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Planetary protection is not just a matter of science. It is also a matter of value. This is so independently of whether we only include the protection of science or if we also include other goals. Excluding other values than the protection of science is thus a value statement, not a scientific statement and it does not make planetary protection value neutral. It just makes the axiological basis (t
For successful climate change adaptation, the distribution of responsibility within society is an important question. While the literature highlights the need for involving both public and private actors, little is still known of how citizens perceive their own and others’ responsibility, let alone the moral groundings for such perceptions. In this paper, we report the results of a survey regardin
Background: Gastric bypass surgery (GBP) provokes rapid improvement of type 2 diabetes (T2D) prior to significant weight loss. Thishas been attributed to altered secretion of the two incretin hormones glucagon-like peptide 1 (GLP-1) and glucose-dependentinsulinotropic polypeptide (GIP). Here we studied the effects of very low calorie diet (VLCD) vs. the immediate effects of GBP onglycaemia and inc
This commentary places Alejandro Parra’s very long list of plagiarisms and data misrepresentations within the context of Dante’s classification of human foibles. The responses from two Argentinean universities are described, along with continuing examples of Parra’s misrepresentations.
Beam characteristics at low energy are an absolute necessity for an acceptable injection in the next stage of a linear accelerator, and are also necessary to reduce beam loss and radiation inside the machine. CEA is taking part of ESS linac construction, by designing Emittance Measurement Units (EMU) for the Low Energy Beam Transport (LEBT). The EMU are designed to qualify the proton beam produced
An online linac model has been developed at MAX IV in order to enable a calculation of the properties of the linac beam based on the actual settings of the magnetic elements. The model is based on the Elegant simulation code and uses the design linac lattice file. A set of Matlab scripts fetch the actual settings of all elements via the Tango control system, pass these values on to Elegant and run
In persons born with myelomeningocele (MMC) secondaryprevention measures are important to survive and to retainfunction. Swedish guidelines in MMC have been developedand a follow-up programme is linked to a quality of care reg-istry, internet-based since 2012. The rationale for creation ofthis registry were to avoid complications in MMC by provid-ing a medical and health overview, facilitate the c
The hybrid combination of two-dimensional (2D) transition metal dichalcogenides (TMDs) and plasmonic materials open up novel means of (ultrafast) optoelectronic applications and manipulation of nanoscale light-matter interaction. However, control of the plasmonic excitations by TMDs themselves has not been investigated. Here, we show that the ultrathin 2D WSe2 crystallites permit nanoscale spatial
We study systems containing oppositely charged colloidal particles under applied alternating current electric fields (AC fields) using overdamped Langevin dynamics simulations in three dimensions. We obtain jammed bands perpendicular to the field direction under intermediate frequencies and lanes parallel with the field under low frequencies. These structures also depend upon the particle charges.
The recent discovery that metal nanoparticles can generate hot carriers upon light excitation is seen as a breakthrough in the fields of plasmonics and photonics. However, the high expectations for a plasmonic revolution in applications have been dampened by the ultrafast energy dissipation of surface plasmon polariton modes. While research aimed at suppressing loss mechanisms is still pursued, an
The electrochemical potential difference (Δμ¯) is the driving force for the transfer of a charged species from one phase to another in a redox reaction. In Li-ion batteries (LIBs), Δμ¯ values for both electrons and Li-ions play an important role in the charge-transfer kinetics at the electrode/electrolyte interfaces. Because of the lack of suitable measurement techniques, little is known about how
Growth approaches that limit the interface area between layers to nanoscale regions are emerging as a promising pathway to limit the interface defect formation due to mismatching lattice parameters or thermal expansion coefficient. Interfacial defect mitigation is of great interest in photovoltaics as it opens up more material combinations for use in devices. Herein, an overview of the vapor-liqui
The physical origin of sub-band gap photoluminescence in Ruddlesden-Poppers two-dimensional (2D) lead halide perovskites (LHPs) is still under debate. In this paper, we studied the photoluminescence features from two different facets of 2D LHP single crystals: the in-plane facet (IF) containing the 2D inorganic layers and the facet perpendicular to the 2D layers (PF). At the IF, the free carriers
Kolinfosfolipider, en nyttig kostkomponent vid alkoholfettlever, NAFLD och NASH?Åke Nilsson, Rui-Dong DuanBakgrundKolin (trimetyletanolamin) ingår i fosfatidylkolin (PC) och sfingomyelin (SM) som finns i alla cellmembraner och i plasmalipoproteiner, och i acetylkolin. Även om levern bildar en del kolin klassas kolin som ett essentiellt näringsämne. Kolinbrist ger bl a fettlever, muskelsymptom och
Motivated by the relevance of Pt clusters in heterogeneous catalysis, ordered Pt cluster superlattices are templated by the moiré of monolayer hexagonal boron nitride (h-BN) with Ir(111). Using X-ray photoelectron spectroscopy, scanning tunneling microscopy, and scanning tunneling spectroscopy, we provide a comprehensive picture for the mechanism of cluster binding, the thermal stability of cluste
The connection with acute myelogenous leukemia (AML) of dihydroorotate dehydrogenase (hDHODH), a key enzyme in pyrimidine biosynthesis, has attracted significant interest from pharma as a possible AML therapeutic target. We recently discovered compound 1, a potent hDHODH inhibitor (IC50 = 1.2 nM), able to induce myeloid differentiation in AML cell lines (THP1) in the low nM range (EC50 = 32.8 nM)
Molecular mechanics combined with Poisson-Boltzmann or generalized Born and solvent-accessible area solvation energies (MM/PBSA and MM/GBSA) are popular methods to estimate the free energy for the binding of small molecules to biomacromolecules. However, the estimation of the entropy has been problematic and time-consuming. Traditionally, normal-mode analysis has been used to estimate the entropy,
