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Association of Lipid-Related Genetic Variants with the Incidence of Atrial Fibrillation : The AFGen Consortium

BACKGROUND: Several studies have shown associations between blood lipid levels and the risk of atrial fibrillation (AF). To test the potential effect of blood lipids with AF risk, we assessed whether previously developed lipid gene scores, used as instrumental variables, are associated with the incidence of AF in 7 large cohorts.METHODS: We analyzed 64,901 individuals of European ancestry without

Designing and feeding multiple characteristic modes in small terminals at frequencies below 1 GHz

Designing multiple antennas in small terminals at frequency bands below 1 GHz is challenging due to severe mutual coupling among antenna elements. The severe coupling is often the result of simultaneous excitation of the fundamental characteristic mode of the terminal chassis by more than one antenna element. In this work, through the use of characteristic mode analysis, we propose to solve the co

An efficient method of calculating signal correlation in lossy dipole arrays based on equivalent circuits

Correlation coefficient, as a critical performance metric of multiple antenna systems, can be calculated from the 3D radiation patterns of the antennas for multipath environments with uniform 3D angular power spectrum. A simpler, faster and lower cost approach uses the antennas’ scattering parameters to determine correlation coefficient. However, the method assumes lossless antennas, and hence onl

Body-worn specific absorption rate for MIMO handsets with different antenna setups

Evaluation of Specific Absorption Rate (SAR) for multiple antenna systems is expected with the upcoming deployment of LTE Advanced, where multi-antennas are excited in both uplink and downlink. In this work, the influence of different antenna locations and antenna types was investigated for stand-alone SAR and simultaneous SAR, to provide some guidelines for antenna design in multi-antenna handset

High frequency vertical InAs nanowire MOSFETs integrated on Si substrates

RF and DC characterization of vertical InAs nanowire MOSFET on Si substrates are presented. Nanowire arrays are epitaxially integrated on Si substrates by use of a thin InAs buffer layer. For device fabrication, high-k HfO2 gate dielectric and wrap-gates are used. Post-deposition annealing of the high-k is evaluated by comparing one annealed and one not-annealed sample. The annealed sample show be

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This biweekly commentary in an Austrian online newspaper presents my reflections upon Bolivian society and politics

Wastewater management analysis for the main cities of Northern Cyprus

Due to political conflicts, the northern part of Cyprus is being under economical crisis. This is employed by environmental problems such as non-organised improvement of residential areas and their effects on habitat. Especially, three main cities where 75 percent of population is crowded, is seriously under the threat of sewerage problems. In this study the comparisons for available sewerage syst

Potential för ökad tillförsel och avsättning av inhemsk biomassa i en växande svensk bioekonomi

I denna studie analyseras potentialen för en ökad tillförsel av biomassa från skog, jordbruk och akvatiska system i Sverige baserat på en sammanställning och bearbetning av aktuella potentialstudier. Analysen inkluderar tekno-ekonomiska begränsningar och minimering av risker för miljömålskonflikter vid en ökad produktion av biomassa. Dessutom analyseras potentialen för en ökad avsättning av biomas

Aberrant activation of the PI3K/mTOR pathway promotes resistance to sorafenib in AML

Therapy directed against oncogenic FLT3 has been shown to induce response in patients with acute myeloid leukemia (AML), but these responses are almost always transient. To address the mechanism of FLT3 inhibitor resistance, we generated two resistant AML cell lines by sustained treatment with the FLT3 inhibitor sorafenib. Parental cell lines carry the FLT3-ITD (tandem duplication) mutation and ar

Complex methods of inquiry: structuring uncertainty

Organizational problem spaces can be viewed as complex, uncertain and ambiguous. They can also be understood as open problem spaces. As such, any engagement with them, and any effort to intervene in order to pursue desirable change, cannot be assumed to be just a matter of ‘complicatedness’. The issue is not just a need to cope with dynamics of system. It is also the perceptual ‘boundedness’ of mu

Multi-injection rate thermal response test with forced convection in a groundwater-filled borehole in hard rock

Convection is shown in earlier studies to improve the thermal contact between heat exchanger and borehole wall in water-filled boreholes. This study investigates the effect of convection on the required borehole length for a ground-coupled heat pump installation. Artificial convection was induced by an ordinary groundwater pump during a multi-injection rate thermal response test (MIR-TRT). For com

Dynamic Single-Leg Postural Control is Impaired Bilaterally Following ACL Reconstruction : Implications for Reinjury Risk

Study Design Controlled laboratory study; cross-sectional. Background Postural control following anterior cruciate ligament reconstruction (ACLR) primarily has been investigated during static single-leg balance tasks. Little is known about dynamic postural control deficits post-ACLR. Objectives To compare dynamic postural control (bilaterally) in persons who have undergone ACLR and healthy control

Genetic predisposition for beta cell fragility underlies type 1 and type 2 diabetes

Type 1 (T1D) and type 2 (T2D) diabetes share pathophysiological characteristics, yet mechanistic links have remained elusive. T1D results from autoimmune destruction of pancreatic beta cells, whereas beta cell failure in T2D is delayed and progressive. Here we find a new genetic component of diabetes susceptibility in T1D non-obese diabetic (NOD) mice, identifying immune-independent beta cell frag

Antithrombin for the prevention of intraventricular hemorrhage in very preterm infants

BACKGROUND: Preterm birth remains the major risk factor for the development of intraventricular hemorrhage, an injury that occurs in 25% of very low birth weight infants. Intraventricular hemorrhage is thought to be venous in origin and intrinsic thromboses in the germinal matrix are likely to play a triggering role. Antithrombin, a glycoprotein synthesized in the liver, is the major plasma inhibi