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SF3B1 is the most mutated splicing factor (SF) in myelodysplastic syndromes (MDSs), which are clonal hematopoietic disorders with variable risk of leukemic transformation. Although tumorigenic SF3B1 mutations have been extensively characterized, the role of “non-mutated” wild-type SF3B1 in cancer remains largely unresolved. Here, we identify a conserved epitranscriptomic program that steers SF3B1
Varje suicid är en personlig tragedi och representerar dessutom en omfattande samhällelig förlust. Problematiken bakom suicid är mångfacetterad och insatser behövs inom många olika domäner i samhället, bland annat finns ett stort behov av nya hälso- och sjukvårdsstrategier. Hälso- och sjukvårdskuratorn med sin tvärvetenskapliga utbildning har möjlighet att bidra till ett multifaktoriellt perspekti
Starting from the assumption that citizenship is propertythat would be more valuable if it were transferable, the paper explores the idea of commodification of citizenship. The paper provides arguments in favor of commodification and recommendations to how the market for citizenships should be designed. A market for citizenships could result in an improved matching between employer and employee whStarting from the assumption that citizenship is valuable private property that would be even more valuable if it were transferable, the paper explores the idea of commodification of citizenship. The paper provides arguments in favor of commodification of citizenship and recommendations to how the market for citizenship should be designed. A market for citizenships could result in an improved matc
I den lilla medeltida byn Chianni i Toscana har olivodlingarna försörjt invånarna i flera hundra år. Varje höst reser markbiologen Håkan Wallander och hans vänner dit för att plocka oliver och sköta om de vackra träden.I Toscanas vänliga landskap kan de experimentera med olika odlingsmetoder i olivlunden. Lokala experter lär dem hur träden traditionellt ska beskäras och gödslas, men som jordforska
Epilepsy is one of the most common neurological disorders that is characterized by recurrent and unpredictable seizures. Wearable systems can be used to detect the onset of a seizure and notify family members and emergency units for rescue. The majority of state-of-the-art studies in the epilepsy domain currently explore modern machine learning techniques, e.g., deep neural networks, to accurately
The last decades have seen frequent calls for a more extended evolutionary synthesis (EES) that will supposedly overcome the limitations in the current evolutionary framework with its intellectual roots in the Modern Synthesis (MS). Some radical critics even want to entirely abandon the current evolutionary framework, claiming that the MS (often erroneously labelled “Neo-Darwinism”) is outdated, a
The physiological performance of organisms depends on their environmental context, resulting in performance–response curves along environmental gradients. Parasite performance–response curves are generally expected to be broader than those of their hosts due to shorter generation times and hence faster adaptation. However, certain environmental conditions may limit parasite performance more than t
This article looks at a sample of academic articles in the field of terrorism studies and international relations to explore the ways in which marriage, sexual activity and close relationships in jihadist groups are framed, imagined and investigated. Despite the scarcity of research being conducted on the subject, this article reveals that, in the study of terrorism, the issue of intimate relation
Objective: To identify prognostic factors for patients with advanced persistent, recurrent, or 2nd primary oral cavity squamous cell carcinoma (OCSCC) potentially unsuitable for salvage surgery with free tissue flap (FTF) reconstruction. Materials and methods: A population-based cohort of 83 consecutive patients with advanced OCSCC who underwent salvage surgery with FTF reconstruction at a tertiar
Background: Five workers from an industry manufacturing various articles from carbon fibre reinforced epoxy plastics were referred to our department because of suspected occupational allergic contact dermatitis (OACD). When patch tested, four of them had positive reactions to components of epoxy resin systems (ERSs) that could explain their current skin problems. All of them had been working at th
Vassiliki “Betty” Smocovitis has done a thorough and admirable job in highlighting the complex history the Modern Synthesis (MS) or the Evolutionary Synthesis (ES) as she prefers to call it. Her interesting contribution should hopefully increase awareness that the history of evolutionary biology is important even for researchers today who are mainly interested in solving practical questions of mor
Purpose: To demonstrate the feasibility and accuracy of chemical shift–encoded imaging of the fatty acid composition (FAC) of human bone marrow adipose tissue at 7 T, and to determine suitable image-acquisition parameters using simulations. Methods: The noise performance of FAC estimation was investigated using simulations with a range of inter-echo time, and accuracy was assessed using a phantom
Background: Resuscitative endovascular balloon occlusion of the aorta (REBOA) is an emerging and potentially life-saving procedure, necessitating qualified operators in an increasing number of centres. The procedure shares technical elements with other vascular access procedures using the Seldinger technique, which is mastered by doctors not only in endovascular specialties but also in trauma surg
The present Multi-view stereo (MVS) methods with supervised learning-based networks have an impressive performance comparing with traditional MVS methods. However, the ground-truth depth maps for training are hard to be obtained and are within limited kinds of scenarios. In this paper, we propose a novel unsupervised multi-metric MVS network, named M 3 VSNet, for dense point cloud reconstruction w
Wood is a porous, hygroscopic material that can take up water both within cell walls (cell-wall water) and in the macrovoid structure (capillary water). Therefore, moisture transport in wood occurs through multiple pathways and phases of water, that is, both cell-wall water, liquid water, and water vapor can be transported through the material structure. The amount of water in wood is quantified b
The advent of deep learning has yielded powerful tools to automatically compute gradients of computations. This is because training a neural network equates to iteratively updating its parameters using gradient descent to find the minimum of a loss function. Deep learning is then a subset of a broader paradigm; a workflow with free parameters that is end-to-end optimisable, provided one can keep t
This article extends the optimal covariance steering (CS) problem for discrete time linear stochastic systems modeled using moment-based ambiguity sets. To hedge against the uncertainty in the state distributions while performing covariance steering, distributionally robust risk constraints are employed during the optimal allocation of the risk. Specifically, a distributionally robust iterative ri
Aim: The aim of the study was to explore the work conditions that influence the opportunities for professional development of specialist nurses in surgical care. Design: A qualitative descriptive design was used. Methods: With a purposeful sampling procedure, 14 specialist nurses in surgical care were included. Four focus-group interviews were conducted during November to December 2021 and deducti
We investigate the problem of risk averse robot path planning using the deep reinforcement learning and distributionally robust optimization perspectives. Our problem formulation involves modelling the robot as a stochastic linear dynamical system, assuming that a collection of process noise samples is available. We cast the risk averse motion planning problem as a Markov decision process and prop
