This interpretive focused-ethnographic study was conducted to illuminate and gain deeper understanding on managers’ everyday cooperative work practices using artefacts. In the dissertation, artefacts refer to digital technologies and information. The doctoral research specifically examines how artefacts in the workplace of an academic library are used in academic library managers’ everyday coopera

As has been argued by systems thinking scholars, science and scientific thinking can be seen as socially constructed systems of institutionalized sets of activities through which systems thinking emerged. In this paper, the development of systems approaches is discussed to argue for the research approach adopted. Further, main concepts of systems thinking such as complexity, worldview, and human a

Recognizing that information has long been an important asset for any organization, I explore in depth the management and use of information in contemporary information-intensive organizations such as academic libraries. Information processes, when integrated in the academic library’s daily working life can lead to workplace learning, with long term benefits. However, the literature demonstrates t

In this paper, I briefly present my doctoral thesis research proposal. Recognizing that information has long been an important asset for any organization, I wish to explore in depth the management and use of information in contemporary information-intensive organizations such as academic libraries. Additionally, this research proposal emerges out of recognition that the academic library is a dynam

In this literature review, the author examines the scholarly literature of Information Management (IM) and related fields in the recognition that information has long been an important asset for any organization. However, nowadays the work environment in organizations is more complicated due to the information overload that employees experience on a daily basis. The information deluge requires emp

The paper presents ethical and legal challenges of holographic communication technologies and suggests a framework to address them. Holographic communications enable the capturing of a user’s 3D depiction via special equipment, and its high-quality transmission to another user located elsewhere, introducing a distinctive data communication experience. Their wrongful use could compromise basic huma

Apolipoprotein E4 (ApoE4) is the most important genetic risk factor for Alzheimer's disease (AD). Among the earliest changes in AD is endosomal enlargement in neurons, which was reported as enhanced in ApoE4 carriers. ApoE is thought to be internalized into endosomes of neurons, whereas β-amyloid (Aβ) accumulates within neuronal endosomes early in AD. However, it remains unknown whether ApoE and A

BACKGROUND: Amyloid-β (Aβ) is a normal product of neuronal activity, including that of the aggregation-prone Aβ42 variant that is thought to cause Alzheimer's disease (AD). Much knowledge about AD comes from studies of transgenic rodents expressing mutated human amyloid-β protein precursor (AβPP) to increase Aβ production or the Aβ42/40 ratio. Yet, little is known about the normal expression of Aβ

OBJECTIVE: Salt-inducible kinase 2 (SIK2) is abundantly expressed in adipocytes and downregulated in adipose tissue from individuals with obesity or insulin resistance. The main aims of this work were to investigate the involvement of SIKs in the regulation of glucose uptake in primary mature human adipocytes and to identify mechanisms underlying this regulation.METHODS: Primary mature adipocytes

This article describes, discusses, and evaluates an educational program aimed at building resilience in public libraries. The program focuses on personal and organizational resilience and builds upon four themes: trust, stress and uncertainty, group identity, and character-strengths. Eighty-seven Swedish public library professionals participated in it. A mixed-method approach was used to study how

BACKGROUND: Integration of oncology and palliative care has been shown to increase quality of life in advanced disease. To meet the needs of the growing older population, integration of palliative care and geriatrics has been proposed but scarcely described.OBJECTIVES: The aim of this study was to integrate palliative care into geriatrics by a structured care guide, the Swedish Palliative Care Gui

Trauma is a highly topical subject of growing relevance in different contexts and scientific traditions that deal with societal challenges and transformation. At the same time, knowledge on different understandings of trauma is still scarce and scattered across disciplines. Against this background, we present and discuss the complexity of trauma understandings from five selected disciplinary persp

Objective: Two predominant phenotypic models of causality exist to explain the high co-occurrence of posttraumatic stress disorder (PTSD) and alcohol use disorder (AUD): the self-medication and susceptibility models. Population-based longitudinal studies that simultaneously examine both models are needed. Thus, the goal of the pres-ent study is to test these models using the Swedish National Regis

Background The authors sought to clarify the impact of spousal psychiatric disorders of differing severity [major depression or anxiety disorders (DAD) v. bipolar disorder or nonaffective psychosis (BPN)] on proband risk for alcohol use disorder (AUD) during marriage. Methods In a Swedish cohort (N = 744 628), associations between spousal DAD and BPN and proband AUD were estimated with Cox proport

The research study focuses on the application of Soft Systems Methodology (SSM) to develop a collaborative user-centered approach within the context of organizational learning, and concludes with suggestions of further research. More specifically, it explores library users’ and academic librarians’ ideal characteristics for the library discovery and access services mediated through the Online Publ

Kommuner och regioner är tillförsäkrade självstyre under riksdagen och regeringen. Självstyrelsen manifesteras av den kommunala rösträtten och den kommunala beskattningsrätten. På en rad sakområden har riksdagen i lag ålagt kommunerna att göra samhällsinsatser, en del av dem finansierade av riksdagen. Kommunerna och regionerna har därmed den rättsliga ställningen som demokratins verkställande orga