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Neuregulin-1 (Nrg1) is genetically linked to schizophrenia, a disease caused by neurodevelopmental imbalance in dopaminergic function. The Nrg1 receptor ErbB4 is abundantly expressed on midbrain dopaminergic neurons. Nrg1 has been shown to penetrate blood-brain barrier, and peripherally administered Nrg1 activates ErbB4 and leads to a persistent hyperdopaminergic state in neonatal mice. These data

The European Spallation Source (ESS) is an intergovernmental project building a multidisciplinary research laboratory based upon the world's most powerful neutron source to be built in Lund, Sweden. The ESS will use a linear accelerator which will deliver protons with 5 MW of power to the target at 2.5 GeV with a nominal current of 50 mA. The superconducting part of the linac consists of over 150

OBJECTIVE: To define a minimum Standard Set of outcome measures and case-mix factors for monitoring, comparing, and improving healthcare for patients with clinically diagnosed hip or knee osteoarthritis (OA) with a focus on defining the outcomes that matter most to patients. METHODS: An international Working Group (WG) of patients, arthroplasty register experts, orthopedic surgeons, primary care

The p_{T}-differential production cross sections of the prompt charmed mesons D^{0}, D^{+}, D^{*+}, and D_{s}^{+} and their charge conjugate in the rapidity interval -0.96

Background: Patients with burns are susceptible to organ failure, and there is indirect evidence that leukocytes may contribute to this process. They may change the expression of cell-surface receptors after certain stimuli, for example, the burn. We therefore aimed to assess the changes induced by the burn in the expression of leukocyte cell-surface receptors CD11b, CD14, CD16, and CD62L on the s

The present study focuses on the acquisition of subject-verb agreement in number in spoken French. We compare production and comprehension of singular and plural verb forms in French monolingual and French-Swedish bilingual children (n=58) aged from five to ten years. Overall, the results demonstrate that subject-verb agreement in number is a challenge to all French-speaking children, be it monoli

A thorough computational study has been performed to investigate oxygen atom transfer (OAT) reactions catalyzed by dimethyl sulfoxide reductase (DMSOR) with a catalytic molybdenum or tungsten ion. Thirteen different density functional theory (DFT) methods have been employed to obtain structural parameters along the reaction pathway, and single-point energies were computed with local correlation co

This article investigates potentials and environmental impacts related to household food waste minimization, based on a case study in Southern Sweden. In the study, the amount of avoidable and unavoidable food waste currently being disposed of by households was assessed through waste composition analyses and the different types of avoidable food waste were classified. Currently, both avoidable and

Concrete structures retrofitted with fibre reinforced plastic (FRP) applications have become widespread in the last decade due to the economic benefit from it. This paper presents a finite element analysis which is validated against laboratory tests of eight beams. All beams had the same rectangular cross-section geometry and were loaded under four point bending, but differed in the length of the

This article maps current approaches to public reporting on waiting times, patient experience and aggregate measures of quality and safety in 11 high-income countries (Australia, Canada, England, France, Germany, Netherlands, New Zealand, Norway, Sweden, Switzerland and the United States). Using a questionnaire-based survey of key national informants, we found that the data most commonly made avai

I denna artikel analyseras muntligt gestaltade erfarenheter hos 27 överlevande efter kriget i nordvästra Bosnien under 1990-talet. Syftet är att dels beskriva hur de intervjuade framställer det sociala fenomenet «offerskap», dels analysera diskursiva mönster som medverkar i konstruktionen av kategorin «offer». Aktörernas anspråk på statusen «offer» skapar en konkurrens om offerrollen efter kriget.The aim of this article is to analyse verbally portrayed experiences of 27 survivors of the 1990’s war in northwestern Bosnia. My focus is on describing how the interviewees portray the social phenomenon of «victimhood» and on analysing the discursive patterns that contribute to construction of the category «victim». When, after the war, different actors claim this «victim» status, it sparks a com

Norway has built up a remarkable solar photovoltaic (PV) industry over the last 15 years with central industrial players such as the Renewable Energy Corporation Group and Elkem. Norwegian companies are mainly active in manufacturing materials for solar cells, but also other elements of the value chain for solar PVs, such as manufacturing of solar cells, recycling of silicone and of solar cells ha

Genetic predisposition has been proposed to be a major determinant in the development of renal complications of diabetes. Osteopontin (OPN) has been suggested to be associated with renal diseases characterized by tubulointerstitial fibrosis and proteinuria. However, information on association of genetic polymorphisms in OPN with diabetic nephropathy is lacking. Thus, the present study was designed

This article presents key energy use figures and explores the energy saving potential for electric lighting in office buildings based on a review of relevant literature, with special emphasis on a North European context. The review reveals that theoretical calculations, measurements in full-scale rooms and simulations with validated lighting programs indicate that an energy intensity of around 10

Aim: To expand the treatment options in paediatric Gorham-Stout syndrome (GSS) when conventional therapy is ineffective. Method: Two children with biopsy confirmed GSS, a rare disorder with progressive lymphangiomatosis, were treated with a combination of interferon-alpha-2b, low anticoagulant, low molecular weight heparin, radiotherapy and surgery. Results: The combined therapy resolved the sympt

Background Trauma and its complications contribute to morbidity and mortality in the general population. Trauma victims are susceptible to acute respiratory distress syndrome (ARDS) and sepsis. Polymorphonuclear leucocytes (PMNs) are activated after trauma and there is substantial evidence of their involvement in the development of ARDS. Activated PMNs release heparin-binding protein (HBP), a gran

The reaction kinetics of Candida antarctica lipase B (CalB) in the commercially available preparation Novozym (R) 435 (N435) were compared to those of preparations of CalB immobilised on Accurel (R) MP1000 (porous polypropylene). Two polypropylene preparations were made using enzyme loadings of 0.2% and 2% (w/w). All three preparations were used in hydrolysis as well as transesterification of two

The prevalence of diabetes has been increasing at an alarming rate worldwide. Treatment of diabetes-related complications adds a huge financial burden on our health services, made worse in the current financial climate. The Eurodiale (European Study Group on Diabetes and the Lower Extremity) study was a prospective observational study conducted in 14 European centers in 2003 to 2004 and included d

The effect of applied potential pulses on DNA functionalization (thiolated single stranded DNA) and hybridization processes has been monitored in-situ on gold surfaces using electrochemical quartz crystal microbalance with dissipation (EQCM-D). The applied potentials were chosen with respect to the potential of zero charge (E-pzc) of the gold surfaces: a positive potential to attract the negativel

AIMS: Several cardiovascular disorders (CVDs) are strongly associated with socioeconomic disparities and neighbourhood deprivation. However, no study has determined whether neighbourhood deprivation is associated with atrial fibrillation (AF). We aimed to determine whether there is an association between neighbourhood deprivation and hospitalization for AF.METHODS AND RESULTS: The entire Swedish p