Global warming is driving environmental change in the Arctic. However, our current understanding of this change varies strongly among different environmental disciplines and is limited by the number and distribution of field sampling locations. Here, we use a quantitative framework based on multivariate statistical modeling to present the current state of sampling across environmental disciplines

I Sverige lär sig de flesta barn cykla innan de börjar skolan och det tas mer eller mindre för givet att alla vuxna kan cykla. Men långt ifrån alla kan. År 2016 startade Cykelfrämjandet projektet ”Frihet på cykel” då intresset av att lära sig cykla och behovet av cykelkurser ökade allt mer. I artikeln, som bygger på ett fältarbete vid cykelkurser för vuxna i Malmö och Stockholm och intervjuer med

Forest ecosystems, covering over a third of land on the Earth, play a significant role in the global hydrological cycle, and influence soil erosion and climate change. However, the distribution, movements, quality of water, and hydrological processes in forested ecosystems are not well understood yet. This thesis aims to improve our understanding of the interaction between forest ecosystems and waForest ecosystems, covering over a third of land on the Earth, play a significant role in the global hydrological cycle, and influence soil erosion and climate change. However, the distribution, movements, quality of water, and hydrological processes in forested ecosystems are not well understood yet. This thesis aims to improve our understanding of the interaction between forest ecosystems and wa

Ett hållbart och acceptabelt pensionssystem måste utformas utifrån personliga förutsättningar och förhållanden i arbetslivet, så att fler klarar att arbeta i högre ålder. Att enbart genom ekonomiska åtgärder höja pensionsåldern är inte långsiktigt hållbart, skriver 54 forskare.DEBATT | PENSIONForskning visar att cirka var fjärde har en diagnos eller skada orsakad av sitt arbete. Detta gör arbetsor

Var fjärde person blir i dag sjuk till följd av sitt arbete. Att höja pensionsåldern för alla yrkesgrupper, utan konkreta åtgärder för att minska ohälsan, är därför problematiskt och mycket oroande. Det är, enligt forskarna, inte långsiktigt samhällsekonomiskt lönsamt att utan andra åtgärder höja pensionsåldern för alla. Vi – 54 forskare – är mycket oroade över konsekvenserna av att, som föreslagi

Raney nickel-2H2O exchange reaction on an epimeric mixture of methyl α/β-D-ribofuranoside [α/β = ∼3:10]1 produced methyl 1#,2,3,4#,5,5′-2H6-α/β-ribofuranoside 2 [97 atom % 2H at C2, C3, C5/5′; ∼85 atom % 2H at C4 (C4#); ∼20 atom % 2H at C1(C1#)] which was obtained in 60 – 80 % yield along with epimeric xylo and arabino by-products. Toluoylation of the crude 2 in dry pyridine and a careful separati

Pure 1′#,2′,3′,4′#,5′,5′'-2H6-ribonucleoside derivatives 10–14, 1′#,2′,″,3′,4′#,5′,5″-2H7-2′-deoxynucleoside blocks 15–18 and their natural-abundance counterparts were used to asemble partially deuterated ribonucleotide-dimers (∗ indicates deuteration at 1′#,2′,3′,4′#,5′,5″(2H6)): ApU∗21, GpC∗22 partially deuterated 2′-deoxyribonucleotide-dimers d(TpA∗) 23, d(ApT∗) 25, d(GpC∗26 (∗ indicates deuter

The concept of the 1H-NMR window has been developed and examined through a comparative study of NOESY spectra of a self-complementary Dickerson's dodecamer (I) [S'd^C^CGWA^T^T^Ci4GisCi6G) 23'] ) a self-complementary 20-mer (II) [(5d(1 C2G3C4G5C6G7C8G9A1 ˚A11T12T13C14G15C16G17C- 18G19C20G)23'] in which the core part consists of the same Dickerson's dodecamer sequence with the flanking CGCG residues

Selective incorporation of the stereospeciflcally deuterlated sugar moieties (\lt;97 atom \% 2H enhancements at H2′, H2″, H3′ and H5′/5′ sites, ∑85 atom \% 2H enhancement at H4′ and ∑20 atom \% 2H enhancement at H1′) in DNA and RNA by the ‘NMR-window’ approach has been shown to solve the problem of the resonance overlap [refs. 1, 2 \amp; 3]. Such specific deuterium labelling gives much improved re

The nucleobase-prolecled parlially-deuteraled 5′-O-DMTr-2′#,2″#,3′,4′#, 5′,5″-2H5-2′-deoxyribonucleoside 3′-phosphoramidite derivatives 17a,b – 20a,b. containing C2′ isolopomeric mixture of deuterons and protons 1~15 atom % 2H at C2′(R), ~85 atom % 2H at C2′(S); 65 atom % 2H at C4′ (#), >97 atom % 2H at C3′ and C5′, i.e. Blocks B and C in Fig. 11, have been site specifically incorporated into a se

The first synthesis of a non-uniformly deuterium labelled 21mer RNA is reported using our ‘NMR-window’ concept, showing its unique application in the unambiguous NMR assignment of the non-exchangeable aromatic and sugar protons.