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Background: Virtual imaging trials (VITs) are in silico studies that simulate medical imaging and disease processes, offering a cost-effective and reproducible addition to traditional imaging trials. While VITs are well established in breast imaging, most existing implementations simulate imaging based on static anatomical models, capturing only a single time point. This limits their ability to st

Accurately forecasting storage demand is a central challenge in multi-tenant, cloud-based Enterprise Resource Planning (ERP) systems, both at the level of individual users of the platform (tenants) and for the platform as a whole. This thesis investigates storage forecasting in a modern cloud ERP system using large-scale, table-level telemetry data. At the tenant level, the thesis addresses the p

Tidigare forskning har visat att militären präglas av maskulina ideal som institutionaliseras och därigenom bidrar till en könssegregerad organisation. Det finns dock begränsad sociologisk forskning som har undersökt hur värnpliktiga kvinnor upplever att soldatrollen är kopplad till kön sedan återinförandet av en könsneutral värnplikt. Syftet med studien är därför att undersöka hur kvinnor inom vä

Residential gardens can provide pollinator habitat and thus contribute to mitigating declines of insect pollinators. To further improve gardens for pollinators, it is necessary to understand the factors and pathways leading to successful conservation interventions. We studied how the success of two common pro-pollinator interventions, garden meadows and flower plantings, were influenced by gardene

Background People with Parkinson’s disease (PD) need life-long rehabilitative interventions to slow disease progression and reduce impact of the disease on daily life activities. To be sustainable for the individual, activities should have a positive impact on physical, cognitive and mental health, and should be appealing and meaningful. Aim To quantitatively evaluate the health-related effects of

A packaging container for pourable food product comprises a first side having a material laminate structure, a first and second transversal seal and a longitudinal seal extending from the first transversal seal to the second transversal seal. An opening device on the first side of the package comprises a tab portion on an outer surface coupled to an opening strip portion via a bridge penetrating t

A package material blank comprises a body panel having a main panel, two second panels arranged adjacent to the main panel and at least one third panel. End closure panels arranged adjacent to the body panel, the end closure panels comprising a top and bottom closure panels arranged adjacent to the main and the at least one third panel, respectively and flap closure panels arranged adjacent to theA package material blank comprises a body panel having a main panel, two second panels arranged adjacent to the main panel and at least one third panel. End closure panels arranged adjacent to the body panel, the end closure panels comprising a top and bottom closure panels arranged adjacent to the main and the at least one third panel, respectively and flap closure panels arranged adjacent to the

Rates of cognitive decline in Alzheimer’s disease (AD) are extremely heterogeneous. Although biomarkers for amyloid-beta (Aβ) and tau proteins, the hallmark AD pathologies, have improved pathology-based diagnosis, they explain only 20–40% of the variance in AD-related cognitive impairment (CI). To discover novel biomarkers of CI in AD, we performed cerebrospinal fluid (CSF) proteomics on 3,397 ind

Background The answer to whether females or males have better health, and which sex is the more disadvantaged, has depended in part on the metric and how the inequality is measured. This study introduces a new method for analyzing and interpreting sex inequalities in health outcomes—defined as the avoidable sex differences in health outcomes—that is systematic and potentially more objective. For t

Wearable devices are becoming a cornerstone for personalized and long-term health monitoring, enabling early intervention and data-driven medical decisions. In this work, we present e-Glass, a state-of-the-art smart wearable device that enables unobtrusive real-time electroencephalography (EEG) monitoring. Our evaluation shows that e-Glass adheres to the established international guidelines for cl

We present a novel method combining existing cosmological simulations and orbital integration to study the hierarchical assembly of globular cluster (GC) populations in the Milky Way (MW). Our method models the growth and evolution of GC populations across various galactic environments as well as the dynamical friction and mass loss experienced by these objects. This allowed us to follow the traje

Scholte wave surveys were conducted at both the laboratory and field scales to evaluate the reliability of distributed acoustic sensing (DAS) with a fiber-optic cable resting on top of unconsolidated sedimentary deposits to determine the distribution of S-wave velocity underneath. Laboratory measurements performed in a controlled environment at the Deltares Laboratory facility demonstrated that DA

Aim: To determine how species richness gradients—commonly considered universal—vary across the phylogenetic hierarchy of birds and mammals, and to uncover how clade age and size predetermine the gradients. Location: Global. Time Period: Last 120 million years. Taxa Studied: Birds and mammals (~15,000 species). Methods: We used large-scale phylogenies of birds and mammals and captured the species r

Non-spherical particles play a crucial role in industrial and geological flows, however, a comprehensive description of their rheology as a function of inertial number and asphericity remains incomplete. In this study, we examine the influence of particle shape using spheroidal particles through simulations of simple shear flow under Lees-Edwards boundary conditions, focusing on the dense flow reg

Alternating shear rotations, also known as tacking, can effectively alter viscosity, the jamming point, and dissipation per strain for dense suspensions. For a given packing fraction, viscosity decreases with increasing cruising (tacking) angle, while dissipation shows a complex dependence on both packing fraction and cruising angle. Generally, the cruising angle required to reduce overall dissipa

The cell cycle is a key regulator of endothelial cell specification into tip and stalk cell phenotypes, which are essential for angiogenesis in both normal development and pathological conditions. While the tumor suppressor p53 is known to regulate the cell cycle and influence cell fate, its role in modulating the cell fate of these phenotypes remains unclear. Using non-genotoxic small molecule an

Background: Surviving sudden cardiac arrest often lead to long-term cognitive, emotional, and physical consequences. Although clinical guidelines recommend structured post-cardiac arrest follow-up, such follow-up is often lacking or inconsistent. Tailored digital interventions are scarce but may help address gaps in follow-up resources. The CARDIS trial evaluates the effects on patient-reported ouBackground: Surviving sudden cardiac arrest often lead to long-term cognitive, emotional, and physical consequences. Although clinical guidelines recommend structured post-cardiac arrest follow-up, such follow-up is often lacking or inconsistent. Tailored digital interventions are scarce but may help address gaps in follow-up resources. The CARDIS trial evaluates the effects on patient-reported ou

Context. The chemical abundances of alpha elements in Galactic Centre (GC) supergiants provide key insights into the chemical enrichment and star formation history of the Milky Way’s nuclear star cluster. Previous studies have reported enhanced alpha-element abundances, which raises questions about the chemical evolution of this unique region. Aims. We aim to reassess the alpha-element abundances