Search results

Filter

Filetype

Your search for "*" yielded 547513 hits

Volumetric modulated arc therapy dose prediction and deliverable treatment plan generation for prostate cancer patients using a densely connected deep learning model

Background and purpose: Radiation therapy treatment planning is a manual, time-consuming task that might be accelerated using machine learning algorithms. In this study, we aimed to evaluate if a triplet-based deep learning model can predict volumetric modulated arc therapy (VMAT) dose distributions for prostate cancer patients. Materials and methods: A modified U-Net was trained on triplets, a co

Transcription Factor-Based Strategies to Generate Neural Cell Types from Human Pluripotent Stem Cells

In the last years, the use of pluripotent stem cells in studies of human biology has grown exponentially. These cells represent an infinite source for differentiation into several human cell types facilitating the investigation on biological processes, functionality of cells, or diseases mechanisms in relevant human models. In the neurobiology field, pluripotent stem cells have been extensively us

TMDlib2 and TMDplotter : a platform for 3D hadron structure studies

A common library, TMDlib2, for Transverse-Momentum-Dependent distributions (TMDs) and unintegrated parton distributions (uPDFs) is described, which allows for easy access of commonly used TMDs and uPDFs, providing a three-dimensional (3D) picture of the partonic structure of hadrons. The tool TMDplotter allows for web-based plotting of distributions implemented in TMDlib2, together with collinear

Predictors of early death in a cohort of Ethiopian patients treated with HAART

BACKGROUND: HAART has improved the survival of HIV infected patients. However, compared to patients in high-income countries, patients in resource-poor countries have higher mortality rates. Our objective was to identify independent risk factors for death in Ethiopian patients treated with HAART.METHODS: In a district hospital in Ethiopia, we treated adult HIV infected patients with HAART based on

Antiretroviral therapy at a district hospital in Ethiopia prevents death and tuberculosis in a cohort of HIV patients

BACKGROUND: Although highly active antiretroviral therapy (HAART) reduces mortality in the developed world, it remains undocumented in resource-poor settings. We assessed the effect of HAART on patient mortality and tuberculosis incidence rate under routine clinical care conditions in Ethiopia. The objective of this study was to assess the effect of HAART on patient mortality and tuberculosis inci

Disease Progression Among Untreated HIV-Infected Patients in South Ethiopia : Implications for Patient Care

CONTEXT: The natural course of HIV disease progression among resource-poor patient populations has not been clearly defined.OBJECTIVE: To describe predictors of HIV disease progression as seen at an outpatient clinic in a resource-limited setting in rural Ethiopia.DESIGN: This prospective cohort study included all adult HIV patients who visited an outpatient clinic at Arba Minch hospital in South

No title

Kronik/op-ed essay on developments among the 9/11 conspiracy theorists, '011 truth movement or 'truthers', and why they should be taken seriously even if they are totally wrong.

Radiological environmental monitoring at the ESS facility – Annual report 2020

Results from the radiological environmental monitoring of the European Spallation Source (ESS) are presented for year 2020.Among the 63 environmental samples analysed for gamma emitting radionuclides, no elevated levels of anthropogenic radioactivity were observed. All samples (except two samples of lichen) had activity concentrations below the MDA for the natural radionuclides as well as 137Cs, a

High dose pollen intralymphatic immunotherapy : Two RDBPC trials question the benefit of dose increase

Background: The same dosing schedule, 1000 SQ-U times three, with one-month intervals, have been evaluated in most trials of intralymphatic immunotherapy (ILIT) for the treatment of allergic rhinitis (AR). The present studies evaluated if a dose escalation in ILIT can enhance the clinical and immunological effects, without compromising safety. Methods: Two randomized double-blind placebo-controlle

Factors influencing late-Holocene vegetation dynamics and biodiversity on Hallands Väderö, SW Sweden : A statistical evaluation

Forest composition characteristic of the Mid-Holocene has survived on Hallands Väderö, an island nature reserve off the south west coast of Sweden. Current veteran Tilia and Quercus trees contribute to a remarkably rich biodiversity of fungi, bryophytes, lichens and insects. Understanding which potential factors influence Holocene vegetation dynamics can support efforts to protect biodiversity, bu

Synthesis of Bacteria Imprinted Polymers by Pickering Emulsion Polymerization

Molecularly imprinted polymers have been studied for a long time and have found useful applications in many fields. In most cases, small organic molecules are used as templates to synthesize imprinted polymers. In contrast to low molecular weight targets, large biological molecules and cells are more challenging to use as templates to synthesize cell-recognizing materials. This chapter presents an

Pipelines and Systems for Threshold-Avoiding Quantification of LC-MS/MS Data

The accurate processing of complex liquid chromatography coupled to tandem mass spectrometry (LC-MS/MS) data from biological samples is a major challenge for metabolomics, proteomics, and related approaches. Here, we present the pipelines and systems for threshold-avoiding quantification (PASTAQ) LC-MS/MS preprocessing toolset, which allows highly accurate quantification of data-dependent acquisit

Cost Effectiveness of Primary Stenting in the Superficial Femoral Artery for Intermittent Claudication : Two Year Results of a Randomised Multicentre Trial

Objective: Invasive treatment of intermittent claudication (IC) is commonly performed, despite limited evidence of its cost effectiveness. IC symptoms are mainly caused by atherosclerotic lesions in the superficial femoral artery (SFA), and endovascular treatment is performed frequently. The aim of this study was to investigate its cost effectiveness vs. non-invasive treatment. Methods: One hundre