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HIP 41378 observed by CHEOPS: Where is planet d?

HIP 41378 d is a long-period planet that has only been observed to transit twice, three years apart, with K2. According to stability considerations and a partial detection of the Rossiter- McLaughlin effect, Pd = 278.36 d has been determined to be the most likely orbital period. We targeted HIP 41378 d with CHEOPS at the predicted transit timing based on Pd = 278.36 d, but the observations show no

Characterisation of the TOI-421 planetary system using CHEOPS, TESS, and archival radial velocity data

Context. The TOI-421 planetary system contains two sub-Neptune-type planets (Pb ~ 5.2 days, Teqb ~ 900 K, and Pc ~ 16.1 days, Teq,c ~ 650 K) and is a prime target to study the formation and evolution of planets and their atmospheres. The inner planet is especially interesting as the existence of a hydrogen-dominated atmosphere at its orbital separation cannot be explained by current formation mode

Observation of ᴧb0→ ᴧc+(*)0K and ᴧb0→ ᴧc+ Ds*− decays

The decays Λb0→Λc +D¯(∗)0K- and Λb0→Λc+Ds∗- are observed for the first time, in proton-proton collision data at s=13TeV, corresponding to an integrated luminosity of 5.4fb-1 collected with the LHCb detector. Their ratios of branching fractions with respect to the Λb 0→Λc +Ds - mode are measured to be (Formula presented.) where the first uncertainties are statistical, the second systematic, and the

The Flow of Everything

Groupexhibition. Philip Dufva, Maria Hedlund och Eva Löfdahl.6 juli 2024–6 oktober 2024Jag betraktar allt som passerar mina ögon och testar det mot ett behov”.Citatet ovan, liksom utställningens titel, är hämtat från Eva Löfdahl – en konstnär som arbetar i många olika material och tekniker, alltid med det specifika behovet hos detta speciella verk som utgångspunkt – snarare än en färdig idé, ett u

Melanoma Incidence and Mortality Trends in Sweden

IMPORTANCE: Over the past decades, many global regions have experienced a steady increase in the incidence of cutaneous melanoma. However, more recently, a downward trend has been observed in the younger age groups in Australia and the US. Yet, in Europe, none of the countries have reported any significant decline in melanoma incidence for any age group.OBJECTIVE: To assess melanoma incidence and

Understanding the genetic complexity of puberty timing across the allele frequency spectrum

Pubertal timing varies considerably and is associated with later health outcomes. We performed multi-ancestry genetic analyses on ~800,000 women, identifying 1,080 signals for age at menarche. Collectively, these explained 11% of trait variance in an independent sample. Women at the top and bottom 1% of polygenic risk exhibited ~11 and ~14-fold higher risks of delayed and precocious puberty, respe

Outcomes of Cytoreductive Radical Prostatectomy for Oligometastatic Prostate Cancer on Prostate-specific Membrane Antigen Positron Emission Tomography : Results of a Multicenter European Study

BACKGROUND: De novo oligometastatic prostate cancer (omPCa) on prostate-specific membrane antigen (PSMA) positron emission tomography (PET) is a new disease entity and its optimal management remains unknown. OBJECTIVE: To analyze the outcomes of patients treated with cytoreductive radical prostatectomy (cRP) for omPCa on PSMA-PET. DESIGN, SETTING, AND PARTICIPANTS: Overall, 116 patients treated wi

Interplay between glypican-1, amyloid-β and tau phosphorylation in human neural stem cells

Introduction: Alzheimer's disease (AD) is characterized by accumulation of amyloid beta (Aβ) and hyperphosphorylated tau (Tau-P) in the brain. Aβ enhances the activity of kinases involved in the formation of Tau-P. Phosphorylation at Thr 181 determines the propagation of multiple tau phosphorylations. Aβ is derived from the amyloid precursor protein (APP). Cleavage of APP by β-secretase also initi

A comparative assessment of five precipitation products in the Saharan desert of Morocco : Sakia El Hamra basin case study

This study evaluates the performance of five satellite precipitation products (GPM IMERG, TRMM 3B42, ERA5, PERSIANN, and CHIRPS) compared to monthly observations from two weather stations (Laayoune and Essmara) over 2001–2017 using statistical metrics including correlation coefficient (CC) and mean square error (MSE). The results reveal notable differences between products. On a monthly timescale,

From ice-dammed lake to aeolian dunes in the Store Mosse area, SW Sweden

Wind is a significant geomorphological agent in formerly glaciated areas and aeolian deposits surround and stretch across the Store Mosse (Great Bog) bog complex in southwestern Sweden. Both peat and aeolian sand are underlain by lacustrine sediment and the deposits record the area's transition from an initially ice-dammed lake to Ancient Lake Bolmen, which gradually drained, exposing sediments to

Hydrometeorological drought analysis through Two-variate Standardized Index for the Paraná River Basin, Brazil

Brazil has faced severe droughts in recent decades, significantly affecting agriculture, water supply, and hydropower generation, among other sectors. The Paraná River Basin, a major hub for hydropower, has been particularly affected, posing challenges for water management. To address this, we conducted a study to provide tailored climate information for the Brazilian hydroelectric sector. Given t

Total mesorectal excision quality in rectal cancer surgery affects local recurrence rate but not distant recurrence and survival : population-based cohort study

Background: The quality of the total mesorectal excision specimen in rectal cancer surgery is assessed with a three-tier grade (mesorectal, intramesorectal and muscularis propria). This study aimed to analyse the prognostic impact of the total mesorectal excision grade on survival, and to identify risk factors for intramesorectal and muscularis propria resection in a population-based setting. Meth

Trauman med suddiga konturer : Att uppmärksamma och bemöta psykisk sårbarhet bland yngre familjehemsplacerade barn

Boken tar upp de allra yngsta familjehemsplacerade barnen – och deras psykiska mående och utveckling. Den utgår från djupintervjuer med familjehem och företrädare för familjehemsvården i flera svenska kommuner. Men den innehåller även en lättillgänglig översikt av senare års kunskapsutveckling om psykisk sårbarhet bland små placerade barn, och vad som enligt forskning är avgörande för att traumati

Meta-analytical evidence for frequency-dependent selection across the tree of life

Explaining the maintenance of genetic variation in fitness-related traits within populations is a fundamental challenge in ecology and evolutionary biology. Frequency-dependent selection (FDS) is one mechanism that can maintain such variation, especially when selection favours rare variants (negative FDS). However, our general knowledge about the occurrence of FDS, its strength and direction remai