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Identification of a small molecule targeting EPLIN as a novel strategy for the treatment of pediatric neuroblastoma and medulloblastoma

Amplification of the MYCN proto-oncogene serves as a key marker of aggressive disease and poor treatment outcomes in certain pediatric tumors originating from the nervous system, including neuroblastoma and medulloblastoma. However, the complex nature of the challenging MYCN protein underscores the urgent need for additional targets and therapies to tackle neuroblastoma and medulloblastoma. In thi

Water Diplomacy - Gender-Inclusive Transboundary Water Governance in the Brahmaputra Basin

This paper examines how gender inclusion in transboundary water governance can be transformed from symbolic to substantive participation in the Brahmaputra Basin. Using qualitative methods including literature review, stakeholder mapping, and 11 semi-structured interviews across India and Bangladesh, the study applies an integrated conceptual framework linking transboundary water governance, multi

Citrobacter spp. bloodstream infection primarily affects the elderly either hospitalized or closely associated with health care – a population-based observational study with comparisons between C. koseri and the C. freundii complex

ObjectivesDespite regularly being found in blood cultures, there are few studies of bloodstream infection (BSI) with Citrobacter. In this population-based study, the aim was to explore patient characteristics, outcome, and incidence in a publicly funded single payer setting.MethodsPatients with growth of Citrobacter in blood culture were identified through the clinical microbiology laboratory in L

Exciting action : investigating efficient exploration for learning musculoskeletal humanoid locomotion

Learning a locomotion controller for a musculoskeletal system is challenging due to over-actuation and high-dimensional action space. While many reinforcement learning methods attempt to address this issue, they often struggle to learn human-like gaits because of the complexity involved in engineering an effective reward function. In this paper, we demonstrate that adversarial imitation learning c

Fast kinodynamic planning on the constraint manifold with deep neural networks

Motion planning is a mature area of research in robotics with many well-established methods based on optimization or sampling the state space, suitable for solving kinematic motion planning. However, when dynamic motions under constraints are needed and computation time is limited, fast kinodynamic planning on the constraint manifold is indispensable. In recent years, learning-based solutions have

A retrospective on the robot air hockey challenge : benchmarking robust, reliable, and safe learning techniques for real-world robotics

Machine learning methods have a groundbreaking impact in many application domains, but their application on real robotic platforms is still limited. Despite the many challenges associated with combining machine learning technology with robotics, robot learning remains one of the most promising directions for enhancing the capabilities of robots. When deploying learning-based approaches on real rob

LS-IQ : implicit reward regularization for inverse reinforcement learning

Recent methods for imitation learning directly learn a Q-function using an implicit reward formulation rather than an explicit reward function.However, these methods generally require implicit reward regularization to improve stability and often mistreat absorbing states.Previous works show that a squared norm regularization on the implicit reward function is effective, but do not provide a theore

Robust localization, mapping, and navigation for quadruped robots

Quadruped robots are currently a widespread platform for robotics research, thanks to powerful Reinforcement Learning controllers and the availability of cheap and robust commercial platforms. However, to broaden the adoption of the technology in the real world, we require robust navigation stacks relying only on low-cost sensors such as depth cameras. This paper presents a first step towards a ro

Dimensionality reduction and prioritized exploration for policy search

Black-box policy optimization is a class of reinforcement learning algorithms that explores and updates the policies at the parameter level. This class of algorithms is widely applied in robotics with movement primitives or non-differentiable policies. Furthermore, these approaches are particularly relevant where exploration at the action level could cause actuator damage or other safety issues. H

Regularized deep signed distance fields for reactive motion generation

Autonomous robots should operate in real-world dynamic environments and collaborate with humans in tight spaces. A key component for allowing robots to leave structured lab and manufacturing settings is their ability to evaluate online and real-time collisions with the world around them. Distance-based constraints are fundamental for enabling robots to plan their actions and act safely, protecting

Learning stable vector fields on Lie Groups

Learning robot motions from demonstration requires models able to specify vector fields for the full robot pose when the task is defined in operational space. Recent advances in reactive motion generation have shown that learning adaptive, reactive, smooth, and stable vector fields is possible. However, these approaches define vector fields on a flat Euclidean manifold, while representing vector f

Long-term visitation value for deep exploration in sparse-reward reinforcement learning

Reinforcement learning with sparse rewards is still an open challenge. Classic methods rely on getting feedback via extrinsic rewards to train the agent, and in situations where this occurs very rarely the agent learns slowly or cannot learn at all. Similarly, if the agent receives also rewards that create suboptimal modes of the objective function, it will likely prematurely stop exploring. More

Continuous action reinforcement learning from a mixture of interpretable experts

Reinforcement learning (RL) has demonstrated its ability to solve high dimensional tasks by leveraging non-linear function approximators. However, these successes are mostly achieved by 'black-box' policies in simulated domains. When deploying RL to the real world, several concerns regarding the use of a 'black-box' policy might be raised. In order to make the learned policies more transparent, we

Challenges and Drivers for the Adoption of Improved Solar Drying Technologies in Mango Farming: A Case Study of Smallholder Farmers in Mozambique

Mango production plays a vital role in rural livelihoods in Mozambique, yet post-harvest losses remain high, ranging from 25% to over 50%, due to inadequate preservation methods. Improved solar drying technologies offer a sustainable solution by extending shelf life and enhancing product quality. However, their adoption among smallholder mango farmers remains limited. This study investigates the k