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Chemotherapy persists as the primary intervention for breast cancer, with chemoresistance posing the principal obstacle to successful treatment. Herein, we show that cartilage oligomeric matrix protein (COMP) expression leads to increased cancer cell survival and attenuated apoptosis under treatment with several chemotherapeutic drugs, anti-HER2 targeted treatment, and endocrine therapy in several
Complement activation protects against infection but also contributes to pathological mechanisms in a range of clinical conditions such as autoimmune diseases and transplant rejection. Complement-inhibitory drugs, either approved or in development, usually act systemically, thereby increasing the risk for infections. We therefore envisioned a novel class of bispecific antibodies (bsAbs) which are
Aqueous liquid suspensions of high aspect ratio 2D clay nanosheets were investigated using small angle X-ray scattering (SAXS). The high aspect ratio of synthetic fluorohectorite clays allows for investigation of liquid crystalline orientational order for relatively large nanosheet spacings, in the range which can produce structural coloration, thus providing two handles for determining the nanosh
The diagnosis of lymphoma relies mainly on clinical examination and laboratory explorations. Among the latter, morphological and immunohistochemical analysis of a tissue biopsy are the cornerstones for proper identification and classification of the disease. In lymphoma with blood and/or bone marrow involvement, multiparameter flow cytometry is useful. This technique can also be applied to fresh c
Respiratory symptoms are ubiquitous and impair health-related quality of life in people with respiratory disease. This European Respiratory Society (ERS) task force aimed to provide recommendations for symptomatic treatment in people with serious respiratory illness. The ERS task force comprised 16 members, including representatives of people with serious respiratory illness and informal caregiver
Background/Aim: To select and stratify patients for optimal treatment plans is challenging. Identification of cancer-related biomarkers that serve as predictors for prognosis and treatment response is essential to better predict treatment outcome and find future targets for therapy. Previous data has suggested ARHGAP4 as a relevant biomarker in colorectal cancer (CRC). The purpose of this study wa
Quantum interference (QI) can strongly affect electric and thermoelectric properties of molecular junctions (MJs). So far, however, a limited number of experimental studies have explored the influence of QI on thermoelectric transport in MJs. To address this open point, we synthesized derivatives of meta-OPE3 with an electron-withdrawing nitro (-NO2) substituent or an electron-donating N,N-dimethy
Strategic critical minerals are essential materials that will dominate the energy transition and technological revolution. In the context of global climate change and industrial transformation, the geopolitical phenomenon of major powers competing for critical minerals has rapidly emerged, yet relevant research remains relatively limited. Therefore, this paper aims to summarize the geopolitical re
Purpose: Tricuspid valve flow velocities are challenging to measure with cardiovascular MR, as the rapidly moving valvular plane prohibits direct flow evaluation, but they are vitally important to diastolic function evaluation. We developed an automated valve-tracking 2D method for measuring flow through the dynamic tricuspid valve. Methods: Nine healthy subjects and 2 patients were imaged. The ap
This is an undeniable fact now that wireless systems pervade all aspects of our lives. These systems are evolving at a rapid clip, connecting more people and devices every single day that goes by. This growth is further fueled by the users’ insatiable appetite for more traffic, be it for online gaming, watching high-fidelity video, downloading huge files, live- streaming and many more uses. With t
This Discussion Paper aims to inform the Escazu Agreement’s (EA) Regional Action Plan on human rights defenders in environmental matters in Latin America and the Caribbean (Regional Action Plan).While most of the attention on defenders is placed in protecting them due to the risks that they face of being threatened or even assassinated, we argue that it is equally important to a) generate knowledg
BackgroundThere is a knowledge gap regarding health-related quality of life (HRQOL) in childhood cancer patients below 2 years of age. The aim of this study was therefore to compare HRQOL of young children during and after treatment for cancer, to healthy controls, and to investigate effects of biopsychosocial factors.ProcedureThe study is based on data from an online monitoring program. Parent-pr
This thesis aims to investigate the interaction between complex morphology and complex phonology in the languages of the Caucasus. The Caucasus is well-known for containing languages with exceptionally large case systems and complex polysynthetic verbal morphology, which is paired with some of the largest consonant inventories in the world outside Africa. The study focuses specifically on nominal
We usually mean what we say, but sometimes we do not. When I ironically utter ‘What lovely weather’ on a rainy day, or mistakenly utter ‘Jim is a barn door’ instead of ‘Jim is a darn bore’, I say one thing and mean another. However, although utterances like these are not uncommon, they are greatly overshadowed by the volume of humdrum utterances of ‘There is wine in the fridge’ or ‘I really like n
Recension av David Van Reybrouck, Revolusi. Natur och Kultur, 2024.
Karin Zackari, universitetslektor i mänskliga rättigheter, visar i sina tillbakablickar att även om universalismen framstår som det svagaste argumentet i samtidens politik, så finns det ett akut behov av en politisk universalism som kommer till uttryck genom konflikter och handlingar. Zackari fokuserar särskilt på den franska filosofen Étienne Balibars intervention i debatten om universalismens mö
Anthropologists of policy have tended to highlight the grand organizational initiatives that are quantitative, standardized and bureaucratic. This article proposes to understand these processes using the term ‘industry’ (as in ‘development industry’ or ‘human rights industry’). Used here, ‘industry’ is not a pejorative but a collection of features, the opposite of which could be called ‘craft’ (lo
