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Results reporting for clinical trials led by medical universities and university hospitals in the Nordic countries was often missing or delayed

OBJECTIVE: To systematically evaluate timely reporting of clinical trial results at medical universities and university hospitals in the Nordic countries.STUDY DESIGN AND SETTING: In this cross-sectional study, we included trials (regardless of intervention) registered in the EU Clinical Trials Registry and/or ClinicalTrials.gov, completed 2016-2019, and led by a university with medical faculty or

Re-designing the Australian dream : Homeness imaginaries in emerging residential typologies

Housing provisions in the Western world, Australia included, are characterised by several challenges. New residential typologies are needed to cope with, for example, environmental and economic considerations of land use, escalating construction cost, and the lack of affordable housing. Urban form determines measures of density. It also spurs our common imaginaries of urban life. Hence,to calibrat

Nanomolar inhibitor of the galectin-8 N-terminal domain binds via a non-canonical cation-π interaction

Galectin-8 is a tandem-repeat galectin consisting of two distinct carbohydrate recognition domains and is a potential drug target. We have developed a library of galectin-8N inhibitors that exhibit high nanomolar K d values as determined by a competitive fluorescence polarization assay. A detailed thermodynamic analysis of the binding of D-galactosides to galectin-8N by isothermal titration calori

The Brussels and California Effects? Circular Economy Policy Influence Across Borders

The influence of environmental policy has been known to move beyond the country or regional contexts in which they have been implemented. Examples in literature include the “California effect” and the “Brussels effect”, showing how the policies adopted in the EU and California influence other jurisdictions. In this paper we study the following: To what extent are companies operating in the United

Role of tau versus TDP-43 pathology on medial temporal lobe atrophy in aging and Alzheimer's disease

Hippocampal atrophy on magnetic resonance imaging is an important biomarker in Alzheimer's disease (AD). While hippocampal atrophy was thought to result from tau tangles in AD, different neuropathologies can lead to hippocampal atrophy, especially TAR DNA-binding protein 43 (TDP-43) pathology. In this narrative review, we evaluate existing studies on the relative contribution of tau and TDP-43 pat