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Substrate diversity affects carbon utilization rate and threshold concentration for uptake by natural bacterioplankton communities

Persistence of dissolved organic matter (DOM) in aquatic environments may in part be explained by high diversity and low concentrations of carbon substrates. However, changes in dissolved substrate quality can modify aquatic bacterial community composition and rate of carbon uptake. The aim of this study was to test if the presence of multiple simple substrates affects the turnover of organic carb

Search for charged-lepton-flavour violation in Z-boson decays with the ATLAS detector

Leptons with essentially the same properties apart from their mass are grouped into three families (or flavours). The number of leptons of each flavour is conserved in interactions, but this is not imposed by fundamental principles. Since the formulation of the standard model of particle physics, the observation of flavour oscillations among neutrinos has shown that lepton flavour is not conserved

What is my teacher talking about? Effects of displaying the teacher’s gaze and mouse cursor cues in video lectures on students’ learning

Eye movement modelling examples (EMME) are instructional videos that display a teacher’s eye movements as “gaze cursor” (e.g. a moving dot) superimposed on the learning task. This study investigated if previous findings on the beneficial effects of EMME would extend to online lecture videos and compared the effects of displaying the teacher’s gaze cursor with displaying the more traditional mouse

Nucleation and growth of iron pebbles explains the formation of iron-rich planets akin to Mercury

The pathway to forming the iron-rich planet Mercury remains mysterious. Its core makes up 70% of the planetary mass, which implies a significant enrichment of iron relative to silicates, while its mantle is strongly depleted in oxidised iron. The high core mass fraction is traditionally ascribed to evaporative loss of silicates, for example following a giant impact, but the high abundance of moder

A low accretion efficiency of planetesimals formed at planetary gap edges

Observations and models of giant planets indicate that such objects are enriched in heavy elements compared to solar abundances. The prevailing view is that giant planets accreted multiple Earth masses of heavy elements after the end of core formation. Such late solid enrichment is commonly explained by the accretion of planetesimals. Planetesimals are expected to form at the edges of planetary ga

High infiltration of CD68+/CD163- macrophages is an adverse prognostic factor after neoadjuvant chemotherapy in esophageal and gastric adenocarcinoma

Tumor-associated macrophages (TAMs) have emerged as key players in tumor immunology but demonstrate a continuum of functional states being either tumor suppressive or promoting. Moreover, chemotherapeutic agents have been shown to alter the tumor microenvironment. Perioperative chemotherapy is a standard treatment option for resectable esophageal and gastric (EG) adenocarcinoma. The aim of this st

Stability of Linear Systems under Extended Weakly-Hard Constraints

Control systems can show robustness to many events, like disturbances and model inaccuracies. It is natural to speculate that they are also robust to sporadic deadline misses when implemented as digital tasks on an embedded platform. This paper proposes a comprehensive stability analysis for control systems subject to deadline misses, leveraging a new formulation to describe the patterns experienc

Weaklyhard. jl: Scalable analysis of weakly-hard constraints

Weakly-hard models have been used to analyse real-time systems subject to patterns of deadline hits and misses. However, the tools that are available in the literature have a set of shortcomings. The analysis they offer is limited to a single weaklyhard constraint and to patterns that specify the number of misses, rather than the number of hits. Furthermore, the scalability of the tools is limited

Deadline-Miss-Adaptive Controller Implementation for Real-Time Control Systems

The policy used to implement a control algorithm in a real-time system can significantly affect the quality of control. In this paper, we present a method to adapt the controller implementation, with the objective to improve the system’s performance under real-time faults. Our method compensates for missing state updates by adapting the controller parameters according to the number of consecutivel

Aβ/Amyloid Precursor Protein-Induced Hyperexcitability and Dysregulation of Homeostatic Synaptic Plasticity in Neuron Models of Alzheimer’s Disease

Alzheimer’s disease (AD) is increasingly seen as a disease of synapses and diverse evidence has implicated the amyloid-β peptide (Aβ) in synapse damage. The molecular and cellular mechanism(s) by which Aβ and/or its precursor protein, the amyloid precursor protein (APP) can affect synapses remains unclear. Interestingly, early hyperexcitability has been described in human AD and mouse models of AD

A retrospective cohort study of the effect of SARS-CoV-2 point of care rapid RT-PCR at the Emergency Department on targeted admission

Background: To prevent nosocomial transmission of SARS-CoV-2, infection prevention control (IPC) measures are implemented for patients with symptoms compatible with COVID-19 until reliable test results are available. This delays admission to the most appropriate ward based on the medical condition. SARS-CoV-2 rapid antigen detection (RAD) tests and point-of-care (POC) rapid RT-PCR (VitaPCR) were i

A Potential Role of Cyclic Dependent Kinase 1 (CDK1) in Late Stage of Retinal Degeneration

Cyclin dependent kinase 1 (CDK1) has long been known to drive the cell cycle and to regulate the division and differentiation of cells. Apart from its role in mitosis regulation, it also exerts multiple functions as a protein kinase, including engagement in cell death, possibly via a cell cycle-independent mechanism. The latter is suggested, since CDK1 re-expression can be found in non-dividing an

Swedish community pharmacy employees' knowledge and experience of substandard and falsified medical products : a cross-sectional descriptive survey

OBJECTIVES: Substandard and falsified medical products are, according to the World Health Organization, a global threat to public health. To evaluate if community pharmacy employees can guide the public to safer medication purchases, their knowledge and experience about SF medical products was examined.METHODS: A digital questionnaire was distributed to the five dominating pharmacy companies in Sw

The shifting role of European unions in the social dialogue: Sweden in a comparative context

Industrial relations vary between European countries. For member countries of the European union, the role of European legislation, labour law and other policy measures play a central and co-ordinating role. The current policy development from the European Commission on minimum wages illustrates the tensions between on one hand the Nordic model with collective agreements and a stronger role from s

Distinguishing tumor from healthy tissue in human liver ex vivo using machine learning and multivariate analysis of diffuse reflectance spectra

The aim of this work was to evaluate the capability of diffuse reflectance spectroscopy to distinguish malignant liver tissues from surrounding tissues, and to determine whether an extended wavelength range (450–1550 nm) offers any advantages over using the conventional wavelength range. Furthermore, multivariate analysis combined with a machine learning algorithm, either linear discriminant analy