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BACKGROUNDAndrogen receptor signaling inhibitors (ARSIs) have improved outcomes for patients with metastatic castration-resistant prostate cancer (mCRPC), but their clinical benefit is limited by treatment resistance.METHODSTo investigate the mechanisms of ARSI resistance, we analyzed the whole-genome (n = 45) and transcriptome (n = 31) sequencing data generated from paired metastatic biopsies obt

This article seeks to develop an understanding of how corporations manage their social and ethical responsibilities, whilst simultaneously facing allegations of crime. It draws on the case of TeliaSonera, a Swedish corporation prosecuted for committing bribery in Uzbekistan. The article begins by introducing the reader to this so-called ‘Uzbek affair’, before exploring how corporate governance has

For victims of corporate harm, accessing justice in the global landscape is fraught with challenges and limitations – but also contestation and conflict. This paper focuses on these issues by directing attention to the National Contact Points (NCPs), a nonjudicial grievance mechanism in this landscape. It explores the puzzle of why complainants, who portray the NCP as a mechanism that is unlikely

Biomassa har varit en central del av Sveriges strategi för att ersätta fossila bränslen de senaste decennierna. Samtidigt pekar flera studier på att efterfrågan på biomassa riskerar att bli större än den hållbara tillgången med en sådan strategi. Detta skapar betydande osäkerhet kring bioenergins framtida roll i energisystemet – både när det gäller var den kommer att behövas, hur konkurrensen med

Genomgång av det oklara käll- och forskningsläget rörande omständigheterna kring inspelningen av Johnny Bodes kult-LP "Bordellmammas visor". Publicerad som inlagetext i nyutgåva 2025.

Smart Firefighting is a concept that has emerged within the fire engineering and fire science disciplines in recent years. It can enable informed decision making and improved fire safety. However, its scope, definition, outcomes, and value to emergency management remain unclear. To investigate this, a scoping review and a bibliometric analysis were conducted, following the Preferred Reporting Item

En av de vanligaste frågorna som brukar ställas till astronomer är om det finns liv någon annanstans i universum. Vi har ännu inget enkelt svar. Framsteg mot ett svar på denna fråga görs lite i taget. Den här avhandlingen är ett av dessa steg.Min forskning är inriktad på atmosfärerna hos så kallade "ultra-hot Jupiters": planeter i Jupiters storlek som kretsar så nära sina stjärnor att de hettas upOne of the biggest questions people ask astronomers is whether life exists elsewhere in the universe. Unfortunately, we don’t yet have an answer. Instead, progress towards an answer comes in small, careful steps. This thesis is one of those steps.My research has focused on the atmospheres of "ultra-hot Jupiters": planets the size of Jupiter that orbit so close to their stars they are heated to tho

The purpose of the article is to present an overview of how convexity serves as a constraint on the semantics of natural language. I begin by presenting four question that a semantic theory should be able to answer. The semantic theory I propose is based on conceptual spaces, which are geometrical or topological structures provided with a betweenness relation. Previously, I have proposed the crite

There are a plethora of methods for solving the classical multi-label document classification problem. However, when it comes to deployment and usage in an industry setting, most if not all the contemporary approaches fail to address some of the vital aspects or requirements of an ideal solution: i) ability to operate on variable-length texts or rambling documents, ii) catastrophic forgetting prob

Rare earth elements (lanthanides) are critical materials for many applications, particularly those involved in new energy. Extracting these elements economically from low-concentration sources may be challenging. This study investigates the interaction of Ce and Gd with microalgae that have been triggered to form phosphate-rich granules. Lanthanides usually occur in nature as phosphates, and there

When exposed to high levels of phosphate after experiencing phosphate deficiency, microalgae can synthesize granules rich in intracellular phosphate. The understanding of the mechanism of production and nature of these granules remains incomplete. Here we studied phosphate distribution and chemistry in Chlamydomonas reinhardtii and Desmodesmus armatus using scanning transmission X-ray microscopy (

Environmental Building Certification (EBC) assessments, involving modelling, simulation, and grading calculation, are often time-consuming, prompting a need for streamlining. This investigation assesses existing Building Energy Modelling (BEM) workflows for Swedish context of EBC, focusing on extracting building geometry from Autodesk Revit with minimal information losses, and considering both low