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Aim: To compare long-term effects of a systemic school-based intervention, Marte Meo and Coordination Meetings (MAC), targeting 3- to 12-year-old children display- ing disruptive behaviour problems (DBP) in preschool or school, and service as usual (SAU). In addition, to examine whether social status (SS) affected the outcomes. Methods: In a randomised controlled design, teachers' and parents' ratAim: To compare long-term effects of a systemic school-based intervention, Marte Meo and Coordination Meetings (MAC), targeting 3- to 12-year-old children display- ing disruptive behaviour problems (DBP) in preschool or school, and service as usual (SAU). In addition, to examine whether social status (SS) affected the outcomes. Methods: In a randomised controlled design, teachers' and parents' rat

This thesis aims to expand on the fundamental knowledge of crystal growth, selectively focusing on the area of particle-seeded nanowire growth in the III-V materials system. The growth process is complex. It typically occurs via the vapor-liquid-solid method, wherein growth material is supplied in the vapor phase, but the solidification process occurs dynamically, layer by layer, via an intermedia

Insulin-dependent (type 1) diabetes mellitus (IDDM) is classified as an autoimmune disorder, since it is associated with specific autoimmunity towards the insulin-producing cells in the islets of Langerhans. The disease process that results in IDDM is not fully understood and whether it is initiated by endogenous or exogenous antigens, or a combination, remains to be clarified. The clinical onset

The cellular interior is a dense environment. Understanding how such an environment impacts the properties of proteins and other macromolecules, as well as how weak, non-specific interactions drive processes such as protein droplet formation through liquid-liquid phase separation, is a major challenge in biological physics. The complexity of this environment often makes experimental studies extrem

The aim of this workshop was to assess the ability of individual autoantibody (ab) assays and their use in combination to discriminate between type 1 diabetic and control sera. Coded aliquots of sera were measured in a total of 119 assays by 49 participating laboratories in 17 countries. The sera were from 51 patients with new onset type 1 diabetes and 101 healthy control subjects with no family h

The rule of law in the EU is not only substantive and formal, it is also procedural. From the early years of European integration until now – and this through the interpretative lens of either the terse Article 31 ECSC or the robust Article 19 TEU - the procedural rule of law has always been thriving and jolting in the case law of both the European Coal and Steal Community (ECSC) Court and the Cou

This thesis examines the daylight compliance of residential spaces, in particular apartments in multi-dwelling building blocks, and provides knowledge that may prove useful for the development of future daylight criteria for dwellings. The implications of design choices on daylight compliance of spaces and the effect of daylight criteria on the level of compliance are at the core of this work. Day

Myocardin-related transcription factors (MRTFs: myocardin/MYOCD, MRTF-A/MRTFA, and MRTF-B/MRTFB) are co-factors of serum response factor (SRF) that activate the smooth muscle cell (SMC) gene program and that play roles in cardiovascular development and mechanobiology. Gain and loss of function experiments have defined the SMC gene program under control of MRTFs, yet full understanding of their imp