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Persistent Aspergillus fumigatus infection in cystic fibrosis : impact on lung function and role of treatment of asymptomatic colonization-a registry-based case-control study

BACKGROUND: Aspergillus fumigatus is the most common filamentous fungus isolated from the airways of people with cystic fibrosis (CF). The aim of this study was to investigate how chronic A. fumigatus colonization affects lung function in people with CF, to identify risk factors for colonization, and to evaluate antifungal treatment of asymptomatic Aspergillus colonization.METHODS: Data from 2014-

Genetic regulation of RNA splicing in human pancreatic islets

BackgroundNon-coding genetic variants that influence gene transcription in pancreatic islets play a major role in the susceptibility to type 2 diabetes (T2D), and likely also contribute to type 1 diabetes (T1D) risk. For many loci, however, the mechanisms through which non-coding variants influence diabetes susceptibility are unknown.ResultsWe examine splicing QTLs (sQTLs) in pancreatic islets fro

Modal analysis of CLT beams: Measurements and predictive simulations

Cross-laminated timber (CLT) as a prime example of an innovative product within the field of civil engineering has over the recent years attracted attention of the construction industry and engineers around the world. As a natural composite with different orientation of layers in addition to anisotropic properties of wood, CLT can be a challenging material in predictive numerical modelling. This i

Long-Short Term Memory Technique for Monthly Rainfall Prediction in Thale Sap Songkhla River Basin, Thailand

Rainfall is a primary factor for agricultural production, especially in a rainfed agricultural region. Its accurate prediction is therefore vital for planning and managing farmers’ plantations. Rainfall plays an important role in the symmetry of the water cycle, and many hydrological models use rainfall as one of their components. This paper aimed to investigate the applicability of six machine le

Unveiling the invisible : Documentary film

Unveiling the invisible (2022) is a short film about the Artistic Research project by Bertrand Chavarría-Aldrete, PhD candidate at Lund University in the form of a workshop for the blind and visually impaired.

Eliciting Anti-Tumor Immunity by Reprogramming Cancer Cells to Type 1 Conventional Dendritic Cells

IntroductionAn important hallmark of cancer is escaping the immune system. Despite advances in immunotherapy, only a subset of patients experiences clinical benefits. It was shown that adoptive T cell or checkpoint inhibition therapy rely on the presence of conventional dendritic cells type 1 (cDC1). cDC1 excel in recruiting and priming protective CD8+ T cells through cross-presentation. However,