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Popular Abstract in Swedish Diabetes är en folksjukdom som kännetecknas av förhöjt blodsocker. Sjukdomens förekomst ökar dramatiskt över hela världen och beskrivs ofta som en pandemi. I huvudsak finns det två olika former av diabetes, typ 1 och typ 2. Typ 1 drabbar oftast barn och ungdomar – de insulinproducerande β-cellerna förstörs av kroppens egna immunförsvar. Vid typ 2 diabetes ser sjukdomsbiDefective insulin secretion and insulin resistance are the two hallmarks of Type 2 Diabetes (T2D). The pathophysiology of the disease is not fully understood but genetic susceptibility for the disease is a new major player in the understanding of the underlying mechanisms. T2D research has in recent years invested tremendous efforts in identifying new risk variants for the disease. It has proven t

Conclusion: Alpha B-crystallin was found to be an independent prognostic marker for poor prognosis in oral cavity tumours. For oropharyngeal cancer, alpha B-crystallin had no prognostic value. Objective: The aim of this study was to see if earlier findings of alpha B-crystallin as an independent prognostic marker, and SPARC/osteonectin, PAI-1 and uPA as a prognostic combination for poor outcome in

Software failures in medical devices can lead to catastrophic situations. Therefore, it is crucial to handle software-related risks when developing medical devices, and there is a need for further analysis of how this type of risk management should be conducted. The objective of this paper is to collect and summarise experiences from conducting risk management with an organisation developing medic

Background: Osteoporosis is increasingly recognised as one of the major public health problems throughout the world and has massive socioeconomic implications. It has previously been shown that patients with severe haemophilia and not receiving any prophylactic treatment render a high risk of reduced bone density. Aims: To evaluate Bone Mineral Density (BMD) in patients with haemophilia of differ

Type 2 diabetes mellitus (T2DM) results from interaction between genetic and environmental factors. The worldwide prevalence of T2DM is increasing rapidly due to reduction in physical activity, increase in dietary intake, and the aging of the population. This thesis has focused on dissecting the genetic contribution in T2DM using largescale genomic approaches with a particular emphasis on analysis

A common approach to distributed control design is to impose sparsity constraints on the controller structure. Such constraints, however, may greatly complicate the control design procedure. This paper puts forward an alternative structure, which is not sparse yet might nevertheless be well suited for distributed control purposes. The structure appears as the optimal solution to a class of coordi

Factor I (FI) is a serine protease that inhibits the complement system by cleaving activated C3 and C4 complement proteins, in the presence of cofactors. Mutations in the gene coding for FI have been identified in complete FI deficient- and atypical hemolytic uremic syndrome (aHUS) patients. The mutations were introduced in recombinantly expressed proteins, purified and analyzed in functional ass

The national system of innovation approach has attracted both academics and policy makers. There has been different emphasis laid by those who both originated the concept and developed it further for policy learning applications. From the firm level to the global innovation networks, the varieties and differences in system of innovation functions, activities and factors continue to attract debate

Using first-principles methods, we study theoretically the properties of an individual {Fe-4} single-molecule magnet (SMM) attached to metallic leads in a single-electron transistor geometry. We show that the conductive leads do not affect the spin ordering and magnetic anisotropy of the neutral SMM. On the other hand, the leads have a strong effect on the anisotropy of the charged states of the m

A search for supersymmetric particles in final states with zero, one, and two leptons, with and without jets identified as originating from b-quarks, in 4.7 fb(-1) of root s = 7 TeV pp collisions produced by the Large Hadron Collider and recorded by the ATLAS detector is presented. The search uses a set of variables carrying information on the event kinematics transverse and parallel to the beam l

The diurnal and seasonal occurrence of flight foraging for midges (Chironomidae) by Black-headed Gulls Chroicocephalus ridibundus was studied at a shallow semi-eutrophic lake in South Sweden and their capture rates were recorded. The gulls captured 0.28 chiromids s(-1) (1,012 h(-1)). With a dry mass of 2.08 mg ind(-1) and an energy content of 22.7 kJ g(-1), they achieved an energy intake of c.47 k

We investigate electron transport in disordered Hubbard chains contacted to macroscopic leads, via the nonequilibrium Green's function technique. We observe a crossover of currents and conductances at finite bias which depends on the relative strength of disorder and interactions. We provide a proof that the coherent potential approximation, a widely used method for treating disorder averages, ful

Bismuth (Bi) induced c(4 x 4) surface structure of the GaAs(1 0 0) substrate, i.e., the GaAs(1 0 0)c(4 x 4)-Bi surface has been studied with synchrotron-radiation photoelectron spectroscopy and ab initio calculations. The surface was prepared by combining molecular beam epitaxy and in situ electron diffraction methods, and then the sample was transferred to a photoemission chamber without breaking

The article takes issue with how theology should and could investigate religious doctrines and praxis. It argues that traditional metaphysical accounts often found in theology are scientifically inept to explain the human cause and function of religious dogma. Arguing from pragmatism the article tries to delineate a framework within which theology could circumvent the troublesome metaphysics that

The repair and maintenance of electrical power lines involves awkward postures, which are known risk factors for developing musculoskeletal disorders. The aim of the present study was to quantify postures and movements of upper arm, head, upper back and neck in the main tasks performed by line workers. Posture of twelve right-handed line workers was recorded by inclinometry and presented as percen

Introduction Autism spectrum disorders (ASDs) are neurodevelopmental disorders characterized by restrictions in social interaction, understanding, and communication, by stereotyped patterns of repetitive behaviors, and by narrow interests. ASDs, which affect about 1% of the population, are predominantly genetic, but no single explanation has been found. On the contrary, a multitude of developmenta

The notions of creativity consultants on how play promotes workplace creativity was investigated. Play is often used by creativity trainers to promote creative performance. Seventeen experienced professionals were interviewed. The informants considered play to facilitate group creativity by increasing openness, intrinsic motivation and collaboration. Play was encouraged by permission to play, that

Using correlated ab initio methods, the polarizability of large [4n + 2]-annulenes is determined, showing that there exists an almost linear relation between the exaltation of magnetic susceptibility (a measure of aromaticity) and an equivalent enlargement of polarizability.

Requirements communication plays a vital role in development projects in coordinating the customers, the business roles and the software engineers. Communication gaps represent a significant source of project failures and overruns. For example, misunderstood or uncommunicated requirements can lead to software that does not meet the customers’ requirements, and subsequent low number of sales or add