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Unique features of β-cell metabolism are lost in type 2 diabetes

Pancreatic β cells play an essential role in the control of systemic glucose homeostasis as they sense blood glucose levels and respond by secreting insulin. Upon stimulating glucose uptake in insulin-sensitive tissues post-prandially, this anabolic hormone restores blood glucose levels to pre-prandial levels. Maintaining physiological glucose levels thus relies on proper β-cell function. To fulfi

There is no such thing as ‘women’s representation’: intersectionality and second-generation gender and politics scholarship

Celis and Childs have called for a ‘second generation’ of feminist scholarship on representation that foregrounds intersectional heterogeneity and emphasises responsiveness to representatives beyond parliaments. We build on these important contributions, arguing that second-generation feminist scholarship and democratic design can make the greatest gains by operationalising intersectionality in cl

Channel Performance Metrics and Evaluation for XR Head-Mounted Displays with mmWave Arrays

Millimeter-wave (mmWave) technology holds the potential to revolutionize head-mounted displays (HMDs) by enabling high-speed wireless communication with nearby processing nodes, where complex video rendering can take place. However, the sparse angular profile of mmWave channels, coupled with the narrow field of view (FoV) of patch-antenna arrays and frequent HMD rotation, can lead to poor performa

Om juridisk fixering och flexibilitet – Den europeiska AI-förordningen och generativ AI

Det här kapitlet pekar på hur europeisk AI-reglering brottas med att reglera ett så exceptionellt rörligt mål som AI-utvecklingen, och visar hur dessa insikter är relevanta för svensk offentlig förvaltning och dess tillsynsmyndigheter när den europeiska AI-förordningen blir tillämplig. Kapitlet pekar på behov av strukturer för kompetensutveckling, samverkan och aktiv tolkning och kommunikation av

Optimal follow-up with somatostatin receptor PET/CT imaging in patients with small intestinal neuroendocrine tumours

Somatostatin receptor positron emission tomography with computerised tomography imaging (SRI) has a high sensitivity for the detection of small intestinal neuroendocrine tumors (siNET), which makes it ideal for follow-up. The aim of the present study was to investigate whether follow-up with SRI in patients with siNET led to any change in the treatment of the patient and if patient and/or tumour f

Short-term aid or long-term gains? : Harnessing Sudan's humanitarian response for the resilience of its health system

The Sudan 2023 Humanitarian Response Plan was revised in May, 2023, due to the escalating violence in the country. This revision increased the scale of assistance and protection activities and suspended the funding allocated for access to livelihood, access to basic services, and for the implementation of resilience solutions. We call to rethink Sudan's current humanitarian response through a pro-

Rejoinder

The response by David Goldsmith to our recently published Economic Affairs article (Andersson & Jonung, 2024) is puzzling. Most prominently, Goldsmith stresses that the correlation between the stringency of lockdowns and excess death rates is close to zero. This is exactly the main point in our article.

Behandling av icke spridd prostatacancer – individuellt val

There is a long history of curative treatment of prostate cancer. However, as prostate cancer often grows very slowly, and symptoms do not have time to develop during a person's lifetime, a more tentative approach has become more and more common in many cases. This may be through either watchful waiting or active surveillance. In the first case palliative hormonal treatment is given in the case of

A comprehensive evaluation of hydrological processes in a second-generation dynamic vegetation model

The global water and carbon cycles are greatly influenced by terrestrial vegetation, making trustworthy representations of dynamic biosphere–hydrosphere interactions a crucial component of both ecosystem and climate models. This paper comprehensively evaluates the hydrological performance of a leading dynamic global vegetation model Lund-Potsdam-Jena General Ecosystem Simulator (LPJ-GUESS), using

AI-assisted capsule endoscopy reading in suspected small bowel bleeding : a multicentre prospective study

Background: Capsule endoscopy reading is time consuming, and readers are required to maintain attention so as not to miss significant findings. Deep convolutional neural networks can recognise relevant findings, possibly exceeding human performances and reducing the reading time of capsule endoscopy. Our primary aim was to assess the non-inferiority of artificial intelligence (AI)-assisted reading

Synchronizing the Western Gotland Basin (Baltic Sea) and Lake Kälksjön (central Sweden) sediment records using common cosmogenic radionuclide production variations

Multi-archive studies of climate events and archive-specific response times require synchronous time scales. Aligning common variations in the cosmogenic radionuclide production rate via curve fitting methods provides a tool for the continuous synchronization of natural environmental archives down to decadal precision. Based on this approach, we synchronize 10Be records from Western Gotland Basin

Factors associated with development of retinopathy in patients with type 2 diabetes mellitus at onset and within three years after diagnosis

Objective: To investigate the prevalence of diabetes retinopathy and evaluate the factors influencing its occurrence both at the onset of type 2 diabetes (T2D) and three years into its duration. Design: Retrospective population-based study. Setting: Data was retrieved from Regional Healthcare Information Platform in Region Halland 2016–2020. Subjects: Patients 35-75 years old in Region Halland rec

Addressing the challenges of lignin oligomer analysis by liquid-based separation techniques : From universal quantification to multidimensional separations

Lignin is the second most abundant biopolymer on Earth after cellulose, found in virtually all plantswhere it is responsible for rigidity, hydrophobicity and mineral transport. For a long time, it has been considereda waste in the paper production process and incinerated for its energy content. However, with the depletion ofcrude oil reserves, it has been found to have a large potential to become

Evidence-Based Guidelines for Advancing Continuous Experimentation

Continuous experimentation (CE) is used by many internet-facing companies to improve the value of their products based on user feedback gathered, e.g. through on-line experiments using A/B testing. Frameworks and theories for CE have been derived through academic research from applications in large internet facing companies. To assist practitioners in a broader range of companies, we herein presen

LOX-1 and MMP-9 Inhibition Attenuates the Detrimental Effects of Delayed rt-PA Therapy and Improves Outcomes after Acute Ischemic Stroke

BACKGROUND: Acute ischemic stroke triggers endothelial activation that disrupts vascular integrity and increases hemorrhagic transformation leading to worsened stroke outcomes. rt-PA (recombinant tissue-type plasminogen activator) is an effective treatment; however, its use is limited due to a restricted time window and hemorrhagic transformation risk, which in part may involve activation of MMPs

Associations between food intake and psychosomatic symptoms in 16-year-old adolescents

Aims: An increase in psychosomatic symptoms among adolescents has recently been reported. Few studies have examined the relation between food intake and psychosomatic symptoms. The aim was to study the association between food intake and overall psychosomatic burden and separate psychosomatic symptoms. Methods: In this cross-sectional study, we used data from 6248 girls and 7153 boys in south-east

α-Synuclein seed amplification assay detects Lewy body co-pathology in autosomal dominant Alzheimer's disease late in the disease course and dependent on Lewy pathology burden

INTRODUCTION: Amyloid beta and tau pathology are the hallmarks of sporadic Alzheimer's disease (AD) and autosomal dominant AD (ADAD). However, Lewy body pathology (LBP) is found in ≈ 50% of AD and ADAD brains. METHODS: Using an α-synuclein seed amplification assay (SAA) in cerebrospinal fluid (CSF) from asymptomatic (n = 26) and symptomatic (n = 27) ADAD mutation carriers, including 12 with known