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Bland vuxna hjärntumörer utmärker sig glioblastom (GBM) genom sin höga förekomst och allvarliga förlopp, och kännetecknas av snabb tumörtillväxt och sin ogynnsamma prognos. Gabapentin är ett läkemedel som ofta används vid nervsmärta och epilepsi, och har nyligen uppmärksammats för sin möjliga påverkan på samspelet mellan tumör och nervsystem med potentiella konsekvenser för GBMs förlopp. I denna Among adult brain cancers, glioblastoma (GBM) stands out for its frequency and severity, characterized by rapid progression and poor prognosis. Gabapentin, a gabapentinoid widely prescribed for managing neurological conditions such as neuropathic pain and seizures, has been proposed to influence tumor-neural interactions and modulates glioblastoma outcomes. This study used real-world clinical data

This thesis investigates the adaptive reuse of Vagnsverkstaden, a former railway maintenance hall in Malmö’s Lokstallarna. The project explores how this early 20th-century industrial structure can be transformed into a multifunctional civic space, while preserving its material and historical character. Using site analysis, theoretical frameworks, and case study comparisons, the proposal introduces

PURPOSE Childhood, adolescent, and young adult (CAYA) survivors of cancer are at risk of nephrotoxicity. Surveillance guidelines are important for timely diagnosis and treatment of these survivors, which could slow the progression to higher stages of kidney dysfunction. METHODS The International Late Effects of Childhood Cancer Guideline Harmonization Group established a multidisciplinary panel of

Background: Rubber accelerators found in rubber gloves may cause contact allergy and thus allergic contact dermatitis. Objectives: To investigate which doses of tetraethylthiuram disulfide (TETD) elicit allergic contact dermatitis by patch testing and in a repeated occluded application test simulating glove use. Patients and Methods: A multicentre study was conducted. Eight patients with contact a

For many years, questions about the future have been marginalised within the social sciences: asking how we might live in a post-fossil society, or what are the key decisions and events that could take us there, has been seen as outside of the disciplinary scope. In this chapter – which takes as its point of departure the ‘speculative turn’ that is increasingly inspiring a range of works, from for

Critical-sized bone defects remain a significant unmet clinical need, with > 500,000 reconstructive procedures performed annually in the United States and Europe and associated costs exceeding US$3 billion. Autologous bone grafting—the current gold standard—suffers from limited harvest volume and donor-site morbidity, whereas allografts show variable integration and carry immunological and infecti

How we teach is strongly influenced by the culture we teach in, especially what (we believe) our colleagues think is good and acceptable. Understanding the reluctance to changes in teaching practice, including fear of disapproval from colleagues and students, investigating and reappraising those fears, and starting to talk about alternative interpretations is a first step towards overcoming the in

Active learning is increasingly implemented in higher education, yet students' perspectives on this pedagogical approach remain diverse. This study explores geoscience students' views on active learning within a course at the University of Bergen (UiB) and in relation to their broader study program. Through longitudinal qualitative interviews with two student cohorts, we identified seven main cate

This thesis examines how psychological traits, specifically self-control and entrepreneurial passion, interact with entrepreneurial intention to predict entrepreneurial action among graduates of a Master's programme in Entrepreneurship and Innovation at Lund University. Guided by the Rubicon Model of Action Phases, we distinguish between the formation of entrepreneurial intention (predecisiona

This study extends the Theory of Planned Behavior by incorporating moral norms and environmental concerns to investigate factors influencing tourists’ biodiversity conservation behaviors in ecologically sensitive destinations. The extended TPB model examines environmental attitudes, subjective norms, perceived behavioral control, moral norms, and environmental concerns. Using a mixed-method approa

Objective: To identify and quantify risk factors for incident knee osteoarthritis (KOA) across the lifespan. Methods: This systematic review and meta-analysis identified eligible studies from seven electronic databases and three registries. Longitudinal cohort studies or randomised controlled trials evaluating participants who developed incident symptomatic and/or radiographic KOA were included. T

Whilst the importance of fungal primary biological aerosol particles (PBAPs) has been recognised, few studies have empirically assessed how land-use patterns influence them. Here, we show the impacts of different land-use patterns on fungal PBAPs within the Brazilian Atlantic Forest biodiversity hotspot. Spanning a distance of ca. 600 km within this biome, we collected fungal bioaerosols in the fo

Purpose: Hexokinase 1 (HK1) encodes a ubiquitously expressed hexokinase, which is responsible for the first step of glycolysis, phosphorylation of glucose to glucose-6-phosphate. Both autosomal recessive and dominant variants in this gene have previously been shown to cause human disease, and presently, there are clinical data available for 27 individuals with the monoallelic neurodevelopmental di

What makes a place meaningful to a community, and what happens to those meanings when the city changes? This thesis investigates architecture's role as both keeper and creator of collective memory in urban environments. Building on sociological theories, this research explores how memories are stored in the built environment, not as static entities but continuously formed, repeated, and trans

All together now: discover how the collective behaviour of atoms, humans, and birds inspire researchers to make new light-emitting materials and devices.

Background: Dronedarone and sotalol are antiarrhythmic drugs (AADs) recommended in similar populations per atrial fibrillation (AF) guidelines; however, comparative safety data are limited. Objectives: The goal of this study was to assess the safety of dronedarone vs sotalol for treatment of AF in AAD-naive patients. Methods: This was a prespecified noninterventional meta-analysis of 4 retrospecti

We investigate differences in resource utilization between a multiprofessional team-based primary care practice and standard care for elderly patients with complex needs, from the perspective of different actors involved in healthcare delivery. The study is based on a mobile care team reform in a Swedish region, that spans across both organisational boundaries and different legislation. Our findin