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Exploring energy citizenship in the urban heating system with the ‘Walking with Energy’ methodology
Background: Energy citizenship has emerged as a concept which attempts to capture the new role envisaged for urban citizens as engaged and active in the energy transition. However, exactly how to successfully engage energy citizens requires more research and this article aims to contribute to this knowledge gap. The article presents a new methodology, ‘Walking with Energy’, which seeks to (re)conn
The unhinged paradox – what does it mean for the energy system?
In man-made energy systems like the electricity system, new concepts have the potential to influence and shape the development of the system. Sometimes the influence leads to a positive development and in other cases the new concept may lead into disadvantageous pathways. In this paper we argue that when a new concept is introduced, it may give rise to an unhinged paradox. An unhinged paradox impl
Drivers and barriers to participation in Sweden’s local flexibility markets for electricity
Local flexibility markets (LFM) for electricity are in their early stages, and most research has focused on their design aspects and aggregators, while little attention has been paid to providers and potential providers of flexibility resources. The present research aims to fill this gap by analysing data from 25 in-depth interviews with enrolled and potential flexibility service providers of two
Öka andelen hållbar konsumtion genom att fokusera på rätt hållbarhetsmål i varumärkesarbetet
Många organisationer har i flera år försökt positionera sig som hållbara, men inte lyckats. Dels är det få kunder som uppmärksammar satsningarna, dels verkar det inte driva deras köpvilja. Nuvarande konjunkturläge gör inte heller hållbarhetsarbetet enklare. Vad kan man göra för att potentiella och nuvarande kunder ska uppmärksamma arbetet man gör och dessutom engagera sig i varumärkets hållbarhets
Health economic aspects of head and neck cancer
Vikings and Nordic Film Culture
A response to The Economist: Shut up and let me grow
Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer
BACKGROUND: Pancreatic Ductal Adenocarcinoma (PDAC) is an aggressive and lethal disease, lacking effective therapeutic approaches. Available therapies only marginally prolong patient survival and are frequently coupled with severe adverse events. It is therefore pivotal to investigate novel and safe pharmacological approaches. We have recently identified the ABC transporter, ABCC3, whose expressio
Concordance between the Stockholm Workshop Scale and the International Consensus Criteria for grading the severity of neurosensory manifestations in hand-arm vibration syndrome in a Swedish clinical setting
OBJECTIVES: Occupational exposure to vibration using hand-held tools may cause hand-arm vibration syndrome (HAVS). Correct diagnosis and grading of severity are crucial in protecting the individual's health and for workers' compensation claims. The International Consensus Criteria (ICC) has been suggested to replace the widely used Stockholm Workshop Scale (SWS). The aims were to, in a clinical se
GPR55 signalling promotes proliferation of pancreatic cancer cells and tumour growth in mice, and its inhibition increases effects of gemcitabine
The life expectancy for pancreatic cancer patients has seen no substantial changes in the last 40 years as very few and mostly just palliative treatments are available. As the five years survival rate remains around 5%, the identification of novel pharmacological targets and development of new therapeutic strategies are urgently needed. Here we demonstrate that inhibition of the G protein-coupled
Pancreatic cancer tumorspheres are cancer stem-like cells with increased chemoresistance and reduced metabolic potential
Cancer stem cells are a population of slow-cycling cells within the tumour bulk, with self-renewal capacity that attracts interest as a therapeutic target. In highly heterogeneous tumours, like pancreatic ductal adenocarcinoma (PDAC) however, the characterisation of cancer stem cells has led to controversial results due to the lack of consensus on specific markers. Here we investigated the charact
Molecular and cellular mechanisms of chemoresistance in pancreatic cancer
Pancreatic Ductal Adenocarcinoma (PDAC) is one of the most chemoresistant cancers, and current therapies targeting cancer-associated molecular pathways have not given satisfactory results, owing in part to rapid upregulation of alternative compensatory pathways. Most of the available treatments are palliative, focussing on improving the quality of life. At present, available options are surgery, e
ABC transporters as cancer drivers : Potential functions in cancer development
BACKGROUND: ABC transporters have attracted considerable attention for their function as drug transporters in a broad range of tumours and are therefore considered as major players in cancer chemoresistance. However, less attention has been focused on their potential role as active players in cancer development and progression.SCOPE OF REVIEW: This review presents the evidence suggesting that ABC
Pancreatic Ductal Adenocarcinoma : Current and Evolving Therapies
Pancreatic ductal adenocarcinoma (PDAC), which constitutes 90% of pancreatic cancers, is the fourth leading cause of cancer-related deaths in the world. Due to the broad heterogeneity of genetic mutations and dense stromal environment, PDAC belongs to one of the most chemoresistant cancers. Most of the available treatments are palliative, with the objective of relieving disease-related symptoms an
Class II Phosphoinositide 3-Kinases as Novel Drug Targets
The phosphoinositide 3-kinases (PI3Ks) are a family of lipid kinases central to regulating a wide range of important intracellular processes. Despite the vast knowledge around class I PI3Ks, the class II PI3Ks have been neglected, seemingly only due to the chronology of their discovery. Here we focus on the cellular functions of the three class II PI3K isoforms, PI3KC2α, PI3KC2β, and PI3KC2γ, in d
ATP-binding cassette transporters in progression and clinical outcome of pancreatic cancer : What is the way forward?
Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive diseases and is characterized by high chemoresistance, leading to the lack of effective therapeutic approaches and grim prognosis. Despite increasing understanding of the mechanisms of chemoresistance in cancer and the role of ATP-binding cassette (ABC) transporters in this resistance, the therapeutic potential of their pharmaco
Chefläkarens roll belyst från ett säkerhetsteoretiskt perspektiv
ABCC3 is a novel target for the treatment of pancreatic cancer
Pancreatic Ductal Adenocarcinoma (PDAC) is a very aggressive disease, lacking effective therapeutic approaches and leaving PDAC patients with a poor prognosis. The life expectancy of PDAC patients has not experienced a significant change in the last few decades with a five-year survival rate of only 8%. To address this unmet need, novel pharmacological targets must be identified for clinical inter
Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation
Acute respiratory distress syndrome (ARDS), an inflammatory condition with high mortality rates, is common in severe COVID-19, whose risk is reduced by metformin rather than other anti-diabetic medications. Detecting of inflammasome assembly in post-mortem COVID-19 lungs, we asked whether and how metformin inhibits inflammasome activation while exerting its anti-inflammatory effect. We show that m