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Studies in primary and tumor cells suggest that MYC plays an important role in regulating cellular senescence, thereby impacting on tumor development. Here we describe different common methods to measure senescence in cell cultures and in tissues. These include measurement of senescence-associated β-galactosidase activity (SA-β-gal), senescence-associated heterochromatin foci (SAHFs), proliferativ
The article aims to illustrate the multifaceted interlink between climate change, heat, and human rights and discuss in what ways international human rights law may be used to support the development and implementation of policy at various levels to limit adverse effects of climate change on humans in general and right to health in particular. This is done by overviewing the possibilities and limi
Projektets syfte är att generera kunskap om ledande företags konfigurering av värdesystem. Syftet kan delas in i fyra delar: 1 Analysera och utveckla definitioner för begreppen strategisk ekonomistyrning (SMA), interorganisatorisk ekonomistyrning (IOMA) och konfigurering. 2 Beskriva användningen och betydelen av strategisk ekonomistyrning och interorganisatorisk ekonomistyrning under konfigurering
I detta kapitel redovisas lärdomar om modeller för BSc som utvecklats som prototyper kallade Cockpit. Teorierna om BSc utvecklas med nya versioner under tiden för vårt Cockpitprojekt. Ett exempel på en vunnen lärdom är när Cockpit utvecklas till ett instrument för kvalitetsstyrning i skolan. Detta har inte visats tidigare. Ett annat sådant exempel är när Cockpit används för att visa ”värde för pen
The configuration of value chains and value systems is of vital importance for the long-term competitiveness and survival of companies. The focus of the study is value systems involving a leading Company. Our main question is: How do leading companies configure boundless value systems?
Educating Social Entrepreneurs: From Idea Generation to Business Plan Formulation appears at a time of unprecedented environmental disasters, natural resources depletion, and significant failure of governments and global businesses to attend to worldwide social problems. In this era of downsizing, restructuring, and social changes, notions of traditional venture creation and the ways of creating s
Non-suicidal self-injury (NSSI) is self-inflicted physical harm that is associated with suicidality, although it is not an expression of suicidal intent. NSSI behaviours range from minor skin scratching to injury requiring medical attention, and in extreme cases, death. NSSI is understood as an effort to modulate emotion in times of crisis and distress. Causal models have been developed for self-h
Educating Social Entrepreneurs: From Idea Generation to Business Plan Formulation appears at a time of unprecedented environmental disasters, natural resources depletion, and significant failure of governments and global businesses to attend to worldwide social problems. In this era of downsizing, restructuring, and social changes, notions of traditional venture creation and the ways of creating s
Det är en kalejdoskopisk text, precis på samma sätt som stora delar av Gustafssons författarskap. Arvidson fokuserar på ett tema, en fråga, ett problem, presenterar ett perspektiv, men vrider konstant på resonemangen så att läsaren efterhand blir varse nya teman, nya frågor, nya problem, nya perspektiv. Komplexa, men fascinerande mönster med oväntade vinklar öppnas för tänkandet – ur efterordetTit
Denna artikel argumenterar för användandet av prototyping vid utveckling av ABC-modeller för att bli anpassade efter organisationens förutsättningar. Genom att engagera controllers och deras medarbetare i prototypingprojekten kan deras erfarenheter av verksamheten byggas in i ABC-prototyper. På så sätt ökas sannolikheten för att det framväxande informationssystemet också svarar mot medarbetarnas i
Background: In low- and middle-income countries, there is a gap between the need for surgery and its equitable provision, and a lack of proxy indicators to estimate this gap. Sierra Leone is a West African country with close to three million children. It is unknown to what extent the surgical needs of these children are met. Aim: To describe a nationwide provision of pediatric surgical procedures
Purpose Previous research shows that the death of a parent places children at risk for a number of negative outcomes. The role of trust in health care at the end of life has been acknowledged as crucial for patients and adult family members. However, the consequences of children’s distrust in the care provided to their parents remain unknown. Therefore, we investigated the negative long-term outco
This paper aims at mapping the challenges of the state of the art of conventional and powder metallurgy (PM) gear manufacture in order to provide knowledge on what parameters need to be considered when modelling the cost and benefit analysis relating to sustainability. An exploratory case study was designed where a series of interviews aimed to identify the complete set of operational steps for bo
Understanding the economic effects of foreign multinational corporations (MNCs) is a priority for academics, policymakers and business professionals alike. In this volume, a number of international economists use factory-level data to analyze the effects of MNCs on wages, productivity and exports in Indonesia and Thailand, in unprecedented detail.
