Search results

Non-endemic Burkitt lymphoma (BL) is a rare germinal centre B-cell-derived malignancy with the genetic hallmark of MYC gene translocation and with rapid tumour growth as a distinct clinical feature. To investigate treatment outcomes, loss of lifetime and relapse risk in adult BL patients treated with intensive immunochemotherapy, retrospective clinic-based and population-based lymphoma registries

In the early eighteenth century, the Sicilian volcano Etna was still primarily familiar to European culture through its many classical associations. This chapter examines the interaction between classical accounts of Etna and other, developing genres of describing and representing that mountain in the writings of some famous eighteenth-century travelers and ‘natural philosophers’. In paving the wa

Neurotrophic tyrosine receptor kinase (NTRK) fusions are promising molecular targets that have been described in a broad range of malignant tumours. Fusions commonly lead to the expression of chimeric proteins with constitutive tyrosine kinase activation that drives tumorigenesis. Despite a low prevalence among most solid tumours (<1%), the first encouraging results with pan-NTRK tyrosine kinase i

Identifying the target proteins of bioactive small molecules is a key step in understanding mode-of-action of the drug and addressing the underlying mechanisms responsible for a particular phenotype. Proteomics has been successfully used to elucidate the target protein profiles of unmodified and ligand-modified bioactive small molecules. In the latter approach, compounds can be modified via click

The radiography profession in Sweden is young but has been rapidly changing over the recent years. The developing profession has led to radiographers facing various challenges related to responsibility for both the technical equipment and patient care in the periradiographic process. Further education is urgent to keep up with the arising level of competence required. The study aimed to explore ra

Conflicts of interest (COIs) can potentially introduce a risk of bias into the assessment of evidence and the formulation of recommendations for guidelines. It is essential that a systematic process for the disclosure and management of COIs is adopted to minimise potential bias in the guideline development process.

Rice and quinoa starch esters were prepared by acylation using short-chain fatty acid anhydrides with different chain lengths (acetic, propionic, and butyric anhydride). A direct stoichiometric method based on the acylation reaction was used to determine the degree of substitution (DS) and acyl content (AC). In addition, Fourier-transform infrared spectroscopy (FTIR) was used to validate the confo

Moringa oleifera leaves are widely used in traditional medicine as a food supplement because they are high in essential and nutritious content. Pressurized hot water extraction (PHWE), which is a green approach, was used for the recovery of the macro-nutrient and micro-nutrient elements from dried leaf powder of Moringa oleifera. In this study, response surface methodology was applied to assess th

We seek to identify factors that facilitate or inhibit transmission of drug abuse (DA) from high-risk parents to their children. In 44,250 offspring of these parents, ascertained from a Swedish national sample for having a mother and/or father with DA, we explored, using Cox models, how the prevalence of DA was predicted by potentially malleable risk factors in these high-risk parents, their spous

Introduction: Despite improved treatments and reduced disability, people with rheumatoid arthritis (RA) experience difficulties in daily life, which may negatively affect their balance of everyday life activities (occupational balance). The aim of this study was to describe occupational balance and its association with self-rated life satisfaction in men and women with RA. Methods: A survey, inclu

Development of new computational methods and testing their performance has to be carried out using experimental data. Only in comparison to existing knowledge can method performance be assessed. For that purpose, benchmark datasets with known and verified outcome are needed. High-quality benchmark datasets are valuable and may be difficult, laborious and time consuming to generate. VariBench and V

During the past decade, the states situated on the territory of the former Soviet Union and in Eastern Europe have made newspaper headlines around the world for topics on gender and sexuality: it seems that each step towards gender equality and inclusive sexual citizenship in the region has been accompanied by counter-actions on different scales. In what way is the present day of appropriate legis