Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To determine the benefits and harms of opioid analgesics in neonates (term or preterm) receiving mechanical ventilation, compared to placebo, no drug, other opioids, other analgesics or sedatives.

Background: Musculoskeletal pain is common in the general population and constitutes a major public health problem. A large proportion of these conditions may be work related. The aim of this study was to explore the relative importance of physical, psychosocial and personal factors, in number of pain sites and in five specific pain sites, among women in common professions with a broad variety of

Metformin is the first-line pharmacotherapy for managing type 2 diabetes (T2D). However, many patients with T2D do not respond to or tolerate metformin well. Currently, there are no phenotypes that successfully predict glycemic response to, or tolerance of, metformin. We explored whether blood-based epigenetic markers could discriminate metformin response and tolerance by analyzing genome-wide DNA

Partially premixed combustion (PPC) is one of the advanced combustion concepts that is being actively investigated. A joint experimental and numerical investigations were conducted to explore the effects of octane number and injection timing on the autoignition behaviour with primary reference fuel (PRF) and gasoline fuels under PPC mode in a light-duty DICI engine. In this study, the start of inj

CO2 is a greenhouse gas that is believed to be one of the main contributors to global warming. Recent studies show that a combination of methanol as a renewable fuel and advanced combustion concepts could be a promising future solution to alleviate this problem. However, high unburned hydrocarbon (UHC) and carbon monoxide (CO) emissions can be stated as the main drawback in low load operations whe

Children with Down syndrome (DS) using intensive computer-based phonics (GraphoGame, GG) were studied. The children's independence and improvement in phonological processing, letter knowledge, word decoding, and reading strategies were investigated. Seventeen children (5-16 years) with DS participated in a crossover design through 8 weeks (one period), with three test sessions separated by 4 weeks

This dissertation concerns a legal development that is currently taking place in Sweden due to its membership in the European Union (EU). It analyses the impact of the EU legal principle on abuse of law (the abuse principle). This principle has been developed gradually under long time in EU law and clarifying rulings from the Court of Justice of the European Union (CJEU) on the general nature of t

A perspective paper about the Swedish ambulance services.