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The activity of the manganese (Mn) efflux transporter SLC30A10 in the liver and intestines is critical for Mn excretion and preventing Mn toxicity. Homozygous loss-of-function mutations in SLC30A10 are a well-established cause of hereditary Mn toxicity. But, the relationship between more common SLC30A10 polymorphisms, Mn homeostasis, and disease is only recently emerging. In 2021, the first coding
Research demonstrates that digital technologies stimulate industrial transformation by enabling new interdependencies with firms outside and across firm and industry boundaries. However, we know little about the degree of novelty and breadth of digital technologies that have the potential to transform industries. Understanding the degree of novelty (spanning from radical to incremental) and breadt
Although the UN concluded, already in 1997, that water would be the most contentious issue of the 21st century, water governance is still confused, nearly everywhere. Even the severe impacts of escalating water bankruptcy and global warming have so far failed to incur a marked improvement in governance systems. The global community has adopted sustainable development as a common vision and guide f
The strength of soil can significantly increase by stabilisation with binders. Adding binders in correct proportions to improve soil parameters is of paramount importance for earthworks. In this article, we presented a framework to explore strength characteristics of soil stabilised by several binders and evaluated using applied geophysical methods by estimated P-wave velocities. The core of our w
Transport and mobility systems need to be transformed to meet climate change goals and reduce negative environmental and social effects. Despite EU policies having targeted such problems for more than three decades, transitions have been slow and geographically uneven. For effective change to happen, transport and mobility research needs fresh perspectives and better integration of knowledge from
Osteoarthritis (OA) is a common musculoskeletal disease that leads to deterioration of articular cartilage, joint pain, and decreased quality of life. When OA develops after a joint injury, it is designated as post-traumatic OA (PTOA). The etiology of PTOA remains poorly understood, but it is known that proteoglycan (PG) loss, cell dysfunction, and cell death in cartilage are among the first signs
Leaching behaviour is an important evidence of soil quality. The assessment of leaching of heavy metals from the contaminated soil is vital for environmental applications. However, leaching may differ in soil stabilised by various ratios of binders. In this study we measured leaching behaviour of soil contaminated by As, Cd, Co, Cr, Cu, Hg, Ni, Pb, V, Zn, met
Introduction: This study investigated the comparability of cerebrospinal fluid (CSF) cutoffs for Elecsys immunoassays for amyloid beta (Aβ)42/Aβ40 or Aβ42/phosphorylated tau (p-tau)181 and the effects of measurement variability when predicting Alzheimer's disease (AD)-related outcomes (i.e., Aβ-positron emission tomography [PET] visual read and AD neuropathology). Methods: We studied 750 participa
In computer-vision feature extraction algorithms, compressing the image into a sparse set of trackable keypoints, empowers navigation-critical systems such as Simultaneous Localization And Mapping (SLAM) in autonomous robots, and also other applications such as augmented reality and 3D reconstruction. Most of those applications are performed in battery-powered gadgets featuring in common a very st
Background: Most studies on long-term follow-up of patients with COVID-19 focused on hospitalised patients. No prospective study with structured follow-up has been performed in non-hospitalised patients with COVID-19. Objectives: To assess long-COVID and post-COVID (WHO definition: symptomatic at least 12 weeks), describe lingering symptoms, their impact on daily activities, and general practice v
Background: Previous research suggests that interactions between preschool teachers and children in early care and educational contexts can contribute to the child’s positive attachment development and socioemotional adjustment. Objective: Investigate how the transition process to preschool is organized and whether various ways of organizing it may differently influence family–teacher relationship
Aims. Stars with strong enhancements of r-process elements are rare and tend to be metal-poor, generally with [Fe/H] < -2 dex, and located in the halo. In this work, we aim to investigate a candidate r-process enriched bulge star with a relatively high metallicity of [Fe/H] ~ -0.65 dex and to compare it with a previously published r-rich candidate star in the bulge. Methods. We reconsidered the ab
People that produce bad outcomes can thereby become the fitting targets of blame, the fitting intensity of which is determined by the badness of the outcomes. In the following paper, I suggest that the amount of blame instances that people are fitting targets of is also determined by the weight of the badness of the outcomes. I use the example of online blame as a paradigmatic case where the amoun
MK-801, also called dizocilpine, is an N-methyl-D-aspartate (NMDA) receptor antagonist widely used in animal research to model schizophrenia-like phenotypes. Although its effects in rodents are well characterised, little is known about the outcomes of this drug in other organisms. In this study, we characterise the effects of MK-801 on the locomotion, sleep, and negative geotaxis of the fruit fly
Context. The solar vicinity is currently populated by a mix of stars with various chemo-dynamic properties, including stars with a high metallicity compared to the Sun. Dynamical processes such as churning and blurring are expected to relocate such metal-rich stars from the inner Galaxy to the solar region. Aims. We report the identification of a set of old super-metal-rich (+0.15 ≤ [Fe/H] ≤ +0.50
Context.Gaia's third data release provides radial velocities for 33 million stars and spectroscopically derived atmospheric parameters for more than 5 million targets. When combined with the astrometric data, these allow us to derive orbital and stellar parameters that are key to understanding the stellar populations of the Milky Way and to perform Galactic archaeology. Aims. We used the calibrate
Context. The high quality of the Gaia mission data has allowed for studies of the internal kinematics of the Large Magellanic Cloud (LMC) to be undertaken in unprecedented detail, providing insights into the non-axisymmetric structure of its disc. Recent works by the Gaia Collaboration have already made use of the excellent proper motions of Gaia DR2 and Gaia EDR3 for a first analysis of this sort
Seaweeds (macroalgae) are gaining attention as potential sustainable feedstock for the production of fuels and chemicals. This comparative study focuses on the characterization of the microbial production of alcohols from fermentable carbohydrates in the hydrolysate of the macroalgae Laminaria digitata as raw material. The potential of a hydrolysate as a carbon source for the production of selecte
