Search results

GTP-cyclohydrolase deficiency in dopa-responsive dystonia (DRD) patients impairs the biosynthesis of dopamine, but also of serotonin. The high prevalence of non-motor symptoms suggests involvement of the serotonergic pathway. Our study aimed to investigate the serotonergic system in vivo in the brain of`DRD patients and correlate this to (non-)motor symptoms. Dynamic [11C]DASB PET scans, a marker

Background and Objectives The neuropathologic changes underlying Alzheimer disease (AD) start before overt cognitive symptoms arise, but it is not well-known how they relate to the first subtle cognitive changes. The objective for this study was to examine the independent associations of the AD hallmarks β-amyloid (Aβ), tau, and neurodegeneration with different cognitive domains in cognitively uni

It is well known that green urban commons enhance mental and physical well-being and improve local biodiversity. We aim to investigate how these outcomes are related in an urban system and which variables are associated with better outcomes. We model the outcomes of an urban common—box gardening—by applying the Social-Ecological Systems (SES) framework. We expand the SES framework by analyzing it

The human amygdala is involved in processing of memory, decision-making, and emotional responses. Previous studies suggested that the amygdala may represent a neurogenic niche in mammals. By combining two distinct methodological approaches, lipofuscin quantification and 14C-based retrospective birth dating of neurons, along with mathematical modelling, we here explored whether postnatal neurogenes

Synthesis of diketopiperazines has been of long-standing interest in both natural product synthesis and medicinal chemistry. Here, we present an operationally convenient and efficient approach to the fused indoline-diketopiperazine tricyclic core of glionitrin A/B and related structures using a Pd-catalyzed C-H activation reaction to form the indoline five-membered ring. Exploratory work aimed at

In our increasingly digitalized society, it is important to have a grasp of basic programming and therefore, programming was recently made mandatory in Swedish schools. We investigated how the mandatory programming education affects self-efficacy and interest in programming in a sample of 12-year-old children (N = 373). Data was collected at the start of the school year, directly after the educati

Background and purpose — Stress fractures of the femoral neck (sFNFs) are uncommon injuries. Studies on sFNFs are rare. We describe the demographics, classification, treat-ment, reoperation rates, and mortality in a cohort of sFNF patients from the Swedish Fracture Register (SFR). Patients and methods — We included 146 patients ≥ 18 years of age with an sFNF registered in the SFR between 2011 and

Significance This project describes the existence of previously unknown non-GPI-anchored CD59 isoforms required for insulin secretion, named CD59-IRIS-1 and CD59-IRIS-2, and finds reduced expression of CD59-IRIS isoforms in human diabetic islets, showing a link between dysregulation of IRIS isoforms and defects in insulin secretion in diabetic patients. These data open a path for future studies in

In this presentation I will discuss the potential of narrative methods to remedy the epistemic injustice that drug users experience within the drug-averse Swedish context, departing from my work with drug-involved women in Sweden. Drug users and, more generally, drug-active individuals have been traditionally considered as unreliable sources of information, requiring the researcher to spend consid

Zinc is an element of importance in many research fields within astronomy and astrophysics, from cosmology to stellar atmosphere dynamics. With the aim of improving three decades old measurements of zinc lines of astrophysical interest, emission spectra of Zn I and Zn II have been recorded using a Fourier Transform Spectrometer with a hollow cathode light source. Revised energies for previously kn

This letter proposes a co-designed millimeter-wave (mm-wave) and sub-6GHz antenna system. The antenna system consists of four 28GHz mm-wave arrays with reconfigurable radiation patterns and two sub-6GHz antennas fed with two corner capacitive coupling elements (CCEs). Each corner CCE is formed by the connected ground planes of two mm-wave arrays in the shared-aperture configuration. The two CCEs a

Sufficiency has long been marginalized in the public and political sustainability discourse. Since attempts to reduce CO2 emissions in the long term have so far fallen short of expectations, sufficiency has recently approached the forefront of scientific and social debates about a »good life«. In addition to a strict reduction target, the sufficiency strategy promises psychological well-being and

With stringent effluent requirements and the implementation of new processes for micropollutant removal, it is increasingly important for wastewater treatment plants (WWTPs) to understand the factors affecting effluent quality. Phages (viruses infecting prokaryotes) are abundant in the biological treatment processes. They can contribute to organic carbon in the treated effluent both because they a

Mylla is an intermedial stage production that addresses our emotional, economic and vital relationship with the earth and how it is changing. The performance drew on interviews with farmers in the Skåne region in Sweden. Mylla unites Liv Kastrup Vesterskov (idea, direction), Halla Steinunn Stefánsdóttir (sound design, composition), Gylleboverket (scenography) and Adam Knapasjö (dramaturgy) and imp

The calendar disk of the fifteenth century astronomical clock in the church of Saint Mary in Gdansk (Poland) contains a wealth of astronomical and calendrical data. We make a statistical analysis of the mean conjunction times of all the mean New Moons as represented on the disk for four Metonic 19-year cycles. We find that the conjunction times were generated using the Alfonsine value for the leng