Hypo-fractionated external beam radiotherapy with narrow CTV-PTV margins is increasingly applied for prostate cancer. This demands a precise target definition and knowledge on target location and extension during treatment. It is unclear how increase in fraction size affects changes in prostate volume during treatment. Our aim was to study prostate volume changes during extreme hypo-fractionation

Sperm performance is likely to be an important determinant of male reproductive success, especially when females copulate with multiple males. Understanding sperm performance is therefore crucial to fully understand the evolution of male reproductive strategies. In this study, we examined the repeatability of sperm morphology and motility measures over three breeding seasons, and we studied relati

We present a detailed comparison of ectopic ossification (EO) found in tendons of biglycan (Bgn), fibromodulin (Fmod) single and double Bgn/Fmod-deficient (DKO) mice with aging. At 3 months, Fmod KO, Bgn KO and DKO displayed torn cruciate ligaments and EO in their quadriceps tendon, menisci and cruciate and patellar ligaments. The phenotype was the least severe in the Fmod KO, intermediate in the

Vid genomgång av anmälningar till Socialstyrelsen avseende missad fraktur i halsryggen noteras flera återkommande brister vid både den kliniska bedömningen och den radiologiska utredningen samt att flertalet av dessa allvarliga vårdskador hade kunnat undvikas.

Key stereoelectronic properties of Desulfovibrio desulfuricans [FeFe]-hydrogenase (DdH) were investigated by quantum mechanical description of its complete inorganic core, which includes a Fe6S6 active site (the H-cluster), as well as two ancillary Fe4S4 assemblies (the F and F' clusters). The partially oxidized, active-ready form of DdH is able to efficiently bind dihydrogen, thus starting H-2 ox

Popular Abstract in Swedish Teamarbete är en populär arbetsform inom hälso- och sjukvården och teamarbete anses kunna göra sjukvården både effektivare och säkrare. Detta gäller inte minst för arbete med kirurgi på operationssal. På operationssalen möts narkosläkare, narkossjuksköterskor, kirurger, operationssjuksköterskor och undersköterskor i olika konstellationer för att tillsammans behandla patThe topic of this thesis is teamwork in healthcare. Healthcare is often described as complex. This description is more appropriate now than ever with the extensive specialization that has taken place in recent decades resulting in increasingly specialized physicians and nurses. While this specialization has made it possible to cure even sicker patients, it has also resulted in less overlapping kno

In previous studies on Supplemental Instruction (SI) relatively little attention has been paid to the “senior” students who lead the sessions. The focus in this study is on the benefits that the SI leaders gain from their SI experience. Data from one questionnaire directed at 35 students who recently completed their assignment as SI leaders, and another questionnaire directed at 20 former SI leade

In light of heightened interest in the response of pollen phenology to temperature, we investigated recent changes to the onset of Betula (birch) pollen seasons in central and southern England, including a test of predicted advancement of the Betula pollen season for London. We calculated onset of birch pollen seasons using daily airborne pollen data obtained at London, Plymouth and Worcester, det

In addition to HPV, high parity and hormonal contraceptives have been associated with cervical cancer (CC). However, most of the evidence comes from retrospective case-control studies. The aim of this study is to prospectively evaluate associations between hormonal factors and risk of developing cervical intraepithelial neoplasia grade 3 (CIN3)/carcinoma in situ (CIS) and invasive cervical cancer

Context Small single-center studies have shown that cerebrospinal fluid (CSF) biomarkers may be useful to identify incipient Alzheimer disease (AD) in patients with mild cognitive impairment (MCI), but large-scale multicenter studies have not been conducted. Objective To determine the diagnostic accuracy of CSF beta-amyloid(1-42) (A beta 42), total tau protein (T-tau), and tau phosphorylated at po

Popular Abstract in Swedish Stroke är ett akut neurologiskt tillstånd och den främsta anledningen till funktionsnedsättning hos vuxna. Det finns ingen behandling för effektiv återhämtning. Den vanligaste formen av stroke orsakas av att mellersta storhjärnsartären blockeras vilket gör att man förlorar hjärnceller, till exempel neuroner. Neurala stamceller (NSCs) skulle kunna användas för att återstStroke is an acute neurological condition and the leading cause of disability in adult humans. Treatments for efficient recovery are not available. The most common form of stroke results from the occlusion of the middle cerebral artery, which causes loss of brain parenchyma and many types of neurons as well as astrocytes and oligodendrocytes. Neural stem cells (NSCs) could potentially be used to d

This report provides a detailed study of attic fires that have occurred in Swedish apartment buildings in order to determine if there are specific technical or organizational factors that influence them. The study has been carried out by a combined analysis of rescue service statistics with case studies based on detailed fire investigations. In the case study a total of 27 fire investigations w

Microphthalmia-associated transcription factor (MITF) is a master regulator of melanocyte development and an important oncogene in melanoma. MITF heterodimeric assembly with related basic helix-loop-helix leucine zipper transcription factors is highly restricted, and its binding profile to cognate DNA sequences is distinct. Here, we determined the crystal structure of MITF in its apo conformation

Motor complications impair quality of life and cause severe disability in patients with advanced Parkinson's disease (PD). Since they are often refractory to medical therapy, interventional therapies have been developed, which can provide a considerable reduction of daily off-time and dopaminergic dyskinesias. Continuous dopaminergic drug delivery (CDD) is based on the steady stimulation of striat