Genetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution in PSA) is associated with reduced prostate cancer risk, however, the functional relevance is unknown. Here, we identify that the SNP variant-induced change in PSA biochemical activity mediates

InBi(0 0 1) is formed epitaxially on InAs(1 1 1)-A by depositing Bi onto an In-rich surface. Angle-resolved photoemission measurements reveal topological electronic surface states, close to the M high symmetry point. This demonstrates a heteroepitaxial system entirely in the III–V family with topological electronic properties. InBi shows coexistence of Bi and In surface terminations, in contradict

We present a detailed depth-sensitive study of the evolution in correlated electron behavior from the surface of the prototypical correlated oxide, SrxCa1-xVO3, to its bulk. Photoemission measurements of varying surface sensitivity are employed to directly compare both the spectral weight and energetics of the correlated electron features, and resonant soft x-ray emission spectroscopy is used as a

(Ga,Mn)As is a model diluted ferromagnet system in which the atomic spins of Mn ions are ferromagnetically arranged due to the exchange interaction with valence band holes. An important tecchnological concern regarding this system has been approaches that might result in reduction of the density of Mn interstitial and increase in the content of Mn in order to make the system practically feasible.

Poor preoperative sleep quality and impaired sleep continuity may heighten acute postoperative pain intensity and increase analgesic consumption, with negative implications for recovery, mental and physical health. The main objective of the current review was to investigate the relationship between preoperative sleep disturbance and acute postoperative pain control. Four electronic databases were

This paper is concerned with the feasibility of the power flow in DC power grids with constant power loads. We introduce the notion of distance to infeasibility as a voltage stability index and robustness measure for power flow feasibility. In particular, we study the p-norm distance to infeasibility in the domain of the constant power loads, and show how this distance may be expressed as a mathem

Purpose: Childhood cancer survivors, in particular those treated with radiation therapy, are at high risk of long-term iatrogenic events. The prediction of risk of such events is mainly based on the knowledge of the radiation dose received to healthy organs and tissues during treatment of childhood cancer diagnosed decades ago. We aimed to set up a standardized organ dose table to help former pati

The Taranta1 project, a collaboration between the MAX IV Institute1 and Square Kilometre Array (SKAO)2 within the Tango3 Collaboration, presents a web-based, no-code approach for creating graphical interfaces dedicated to monitoring and controlling Tango-based systems. Through an active development phase and close collaboration with the community, the software has seen the introduction of advanced

International corporate criminal responsibility has been discussed by scholars and practitioners as an avenue for bringing corporations to account for some of their wrongdoing for more than two decades. This thesis focuses on how thinking about the international corporate criminal responsibility project as ideology can further our understanding of the relationship between the corporate form, corpo

Background: In experimental studies, several polycyclic aromatic hydrocarbons (PAHs) have shown endocrine disrupting properties, but very few epidemiological studies have examined their impact on pubertal development and results have been heterogenous. Objective: To explore if maternal PAH exposure during pregnancy was associated with the offspring's timing of pubertal onset. Methods: We studied 5

The aim of this study was to investigate Swedish children's and parents' attitudes and knowledge about human papillomavirus (HPV) vaccination a year after gender-neutral HPV vaccination was introduced in Sweden's national immunization program (NIP). Additional information about HPV and vaccine was provided in the extended immunazation program. In total, 276 parents and 206 children from 22 School

High-order harmonic generation (HHG) supplies extreme ultraviolet (XUV) radiation with attosecond pulse duration for a wide variety of applications from fundamental research to industry. As HHG is a very inefficient process, enhancing the XUV flux is of great interest. Hereby, either the HHG process itself or the laser which is the primary driver of HHG can be optimized.Currently, the technology i

Sub-Saharan Africa stands at a critical juncture between repeating historical boom-and-bust cycles and achieving sustained economic prosperity. While recent growth has sparked hope, this book goes beyond growth to examine the structural changes that shaped the region’s economies since independence. It reveals that today’s growth is built on improved foundations compared to past growth spurts. The

a-1-Microglobulin (A1M) is a circulating glycoprotein with antioxidant, heme-binding, and mitochondrial protection properties. The investigational drug RMC-035, a modified therapeutic A1M protein, was assessed for biodistribution and pharmacological activity in a broad set of in vitro and in vivo experiments, supporting its clinical development. Efficacy and treatment posology were assessed in var