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Monoamine theories associate depression with reduced brain monoamine levels. These theories achieved broad popularity in the mid-1960s. The present article reviews the historical development of monoamine theories and their subsequent impact on biomedical research. Alleged divisions between West European and U.S. researchers over competing versions of the theories are investigated using bibliometri
The origin of modern fruits brought to microbial communities an abundant source of rich food based on simple sugars. Yeasts, especially Saccharomyces cerevisiae, usually become the predominant group in these niches. One of the most prominent and unique features and likely a winning trait of these yeasts is their ability to rapidly convert sugars to ethanol at both anaerobic and aerobic conditions.
Weight changes are common in aging and Alzheimer's disease (AD) and postmortem findings suggest a relation between lower body mass index (BMI) and increased AD brain pathology. In the current multicenter study, we tested whether lower BMI is associated with higher core AD brain pathology as assessed by cerebrospinal fluid (CSF)-based biological markers of AD in 751 living subjects: 308 patients wi
Objective Systemic lupus erythematosus (SLE) is an autoimmune disease with chronic or episodic inflammation in several organ systems, related to the presence of circulating and tissue-deposited immune complexes (ICs) that stimulate leukocytes through Fc? receptors (Fc?R) with subsequent inflammation. Treatment with endoglycosidase S (EndoS), an IgG glycanhydrolyzing bacterial enzyme from Streptoco
Solaris synchrotron storage ring which has been assembled at the beginning of the 2015, consist of twelve integrated magnets blocks performing the part of double bend achromat. Both magnets as well as the whole ring as concept is a replica of Max IV 1.5 GeV ring and utilize pioneering integrated magnets approach. Solaris ring assembly forewent that of its Swedish twin. It is a successful proof of
What is the central question of this study? Does the exocrine pancreas have an impact on endocrine pancreatic function and peripheral nutrient utilization? What is the main finding and its importance? In an exocrine pancreas-insufficient pig model, the insulin response to a glucose load was delayed. Oral enzyme supplementation did not improve the insulin release but facilitated blood glucose clear
Immune activation is a regular feature of sepsis, but the incidence and nature of the ensuing inflammation-resolving and immunosuppressive component is less well understood. In this study, we compared immunoregulatory markers on blood leukocytes from patients with Gram-negative or Gram-positive sepsis or septic shock, and compared this to blood from patients with severe virosis or healthy controls
A micromechanically motivated model is proposed to capture nonlinear effects and switching phenomena present in ferroelectric polycrystalline materials. The changing remnant state of the ferroelectric crystal is accounted for by means of so-called back fields-such as back stresses-to resist or assist further switching processes in the crystal depending on the local loading history. To model interg
In this contribution we study the balloon angioplasty in a residually stressed artery by means of a non-local gradient-enhanced fibre damage model. The balloon angioplasty is a common surgical intervention used to extend or reopen narrowed blood vessels in order to restore the continuous blood flow in, for instance, atherosclerotic arteries. Inelastic, i.e. predominantly damage-related and elastop
Entrained flow gasification of biomass using the cyclone principle has been proposed in combination with a gas engine as a method for combined heat and power production in small to medium scale (<20 MW). This type of gasifier also has the potential to operate using ash rich fuels since the reactor temperature is lower than the ash melting temperature and the ash can be separated after being collec
The current research focuses on creating a homogeneous charge compression ignition (HCCI) fuel index suitable for comparing different fuels for HCCI operation. One way to characterize a fuel is to use the auto-ignition temperature (AIT). The AIT can be extracted from the pressure trace. Another potentially interesting parameter is the amount of low temperature heat release (LTHR) that is closely c
Knee osteotomy is a joint preserving surgery with new techniques and implants introduced during recent years. However the information of its use and outcome is scarce. A national knee osteotomy register was started in Sweden in 2013 from which we report here the information gathered during the first year of registration.
Four randomized studies show that adjuvant radiotherapy (RT) lowers the risk of subsequent ipsilateral breast events (IBEs) after breast-conserving surgery (BCS) for ductal carcinoma in situ (DCIS) by approximately 50% after 10 to 15 years. We present 20 years of follow-up data for the SweDCIS trial.
Background: Social and lifestyle influences on age-related changes in body morphology are complex because lifestyle and physiological response to social stress can affect body fat differently. Objective: We examined the associations of socioeconomic status (SES) and lifestyle factors with body mass index (BMI) and waist circumference (WC) in middle-aged and elderly European men. Design and setting
Except for the scattered cephalopod conchs that have given the rock type its name, mollusk fossils are relatively rare in the Middle Ordovician 'orthoceratite limestone' of Sweden. However, an interval in the Darnwilian stands out as being unusually rich in various types of mollusks. Throughout southern Sweden, gastropods became relatively abundant close to the Volkhov-Kunda Baltoscandian Stage bo
The HIV-1 capsid protein, p24 antigen, is of considerable diagnostic interest because following HIV exposure it is detectable several days earlier than host-generated HIV antibodies (which are the target of almost all current tests used in the field) and can be used to design very sensitive assays without the need for PCR. Here, we present an ultrasensitive capacitive immunosensor that is capable
This study investigates the retention of different sized ultra-small superparamagnetic iron oxide nanoparticles (USPIOs) in lymph nodes of healthy rats, after subcutaneous injection. Three distinct sizes (15, 27 and 58 nm) of USPIOs were synthesized by only varying the thickness of the polymer coating surrounding the 10 nm cores. Particles were injected on the dorsal side of the hind paw of rats a
The use of light emitting diodes (LEDs) in outdoor lighting has energy-saving potential, but users' responses to this light source are largely unknown. An intervention study in two residential areas compared conventional lighting installations (high pressure sodium in Area 1 and high pressure mercury in Area 2) to a retrofitted LED-alternative regarding residents' perceptions of quality of light,
Abstract is missing (Short Communication).
Some observational evidence-such as bimodal drop size distributions, comparatively high concentrations of supercooled drops at upper levels, high concentrations of small ice crystals in cloud anvils leading to high optical depth, and lightning in the eyewalls of hurricanes-indicates that the traditional view of the microphysics of deep tropical maritime clouds requires, possibly, some revisions. I
