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Background Creating new therapies often involves drug companies paying healthcare professionals and institutions for research and development (R&D) activities, including clinical trials. However, industry sponsorship can create conflicts of interests. We analysed approaches to drug company R&D payment disclosure in European countries and the distribution of R&D payments at the country

The fragmentation properties of jets containing b-hadrons are studied using charged B mesons in 139 fb−1 of pp collisions at s√ = 13 TeV, recorded with the ATLAS detector at the LHC during the period from 2015 to 2018. The B mesons are reconstructed using the decay of B± into J/ψK±, with the J/ψ decaying into a pair of muons. Jets are reconstructed using the anti-kt algorithm with radius parameter

α-synuclein is an intrinsically disordered protein implicated in synaptic vesicle trafficking at the synapse. Accumulation of α-synuclein in the form of amyloid deposits coincides with the loss of dopaminergic neurons in Parkinsons disease. These deposits, referred to as Lewy Bodies, have been shown to contain membrane lipids together with the α-synuclein amyloid fibrils and other proteins. It was

In ordinary public rooms, such as classrooms and offices, an absorbent ceiling is the typical first acoustic action. This treatment provides a good acoustic baseline. However, an improvement of specific room acoustic parameters, operating for specific frequencies, can be needed. It has been seen that diffusing elements can be effective additional treatment. In order to choose the right design, pla

Introduction: Academic achievement (AA) is associated with smoking rates. Can we determine the degree to which this relationship is likely a causal one? Methods: We predict smoking in male conscripts (mean age 18.2) assessed from 1984 to 1991 (N = 233 248) and pregnant females (mean age 27.7) receiving prenatal care 1972-1990 (N = 494 995) from AA assessed in all students at 16. Instrumental varia

X-ray diffraction is an invaluable tool in the field of structural dynamics. In the work described in this thesis, time-resolved X-ray diffraction experiments were carried out to investigate ultrafast lattice dynamics. Ultrashort laser pulses were used to induce non-thermal melting and large-amplitude strain waves, and X-rays were used to probe these phenomena. Non-thermal melting was studied in i

Uanset hvilken målestok man bruger for en retfærdig fordeling af det globale klimabudget må man konstatere, at den danske klimapolitik er langt fra tilstrækkelig ambitiøs.

The chapter provides a comparative overview of current hiring and learning strategies in prosecution services. It draws on empirical examples from all parts of the world. Specifically, the chapter compares the hiring of chief prosecutors and frontline prosecutors, it compares how learning is organized and carried out, and it describes and discusses the most significant individual methods of learni

The capacitive biosensor technology can be utilized for the analytical detection of a variety of different compounds. By employing the electrical double-layer principle, it is possible to detect very low concentrations of the target analyte due the methods inherent high sensitivity. This affinity-based capacitive biosensor is a powerful tool also for the analytical detection of low molecular weigh

Already in the 16th century, archbishop Mogens Madsen described the area around the castle on the steep escarpment overlooking the narrowest strait in Öresund, as a vanished Troy. The historian Ludvig Magnus Bååth, who wrote the first academic work on the history of Helsingborg, promoted this narrative of an original urban settlement on the top of the escarpment. The paramount argument for an urba

Plant mitochondria are indispensable for plant metabolism and are tightly integrated into cellular homeostasis. This review provides an update on the latest research concerning the organization and operation of plant mitochondrial redox systems, and how they affect cellular metabolism and signaling, plant development, and stress responses. New insights into the organization and operation of mitoch

Objectives: To assess secular trends in baseline characteristics of PsA patients initiating their first or subsequent biologic DMARD (bDMARD) therapy and to explore prescription patterns and treatment rates of bDMARDs from 2006 to 2017 in the Nordic countries. Methods: PsA patients registered in the Nordic rheumatology registries initiating any treatment with bDMARDs were identified. The bDMARDs w

Objective: To compare mortality risk over up to 14 years of follow-up in methotrexate-refractory patients with early RA randomized to a strategy starting with addition of infliximab vs addition of SSZ and HCQ. Methods: Data was from the two-arm, parallel, randomized, active-controlled, open-label Swefot trial in which patients with early RA (symptom duration <1 y) were recruited from 15 rheumatolo

Objectives: To estimate the incidence and strength of association of extra-articular manifestations [EAMs, here: anterior uveitis (AU), IBD and psoriasis] in patients with AS, undifferentiated SpA (uSpA) and PsA, compared with controls. Methods: Three mutually exclusive cohorts of patients aged 18-69 years with AS (n = 8517), uSpA (n = 10 245) and PsA (n = 22 667) were identified in the Swedish Na

The electrification of road bound transport is to some extent limited by the large cost of the energy storage required on-board the vehicles, i.e., the cost of the battery. One way of reducing the required capacity of the on-board energy storage is to enable the possibility to supply the vehicles with electrical energy while it is moving, also called dynamic charging. The energy transfer is usuall

The clinical use of surface imaging has increased dramatically, with demonstrated utility for initial patient positioning, real-time motion monitoring, and beam gating in a variety of anatomical sites. The Therapy Physics Subcommittee and the Imaging for Treatment Verification Working Group of the American Association of Physicists in Medicine commissioned Task Group 302 to review the current clin

Objectives: Antibodies against anti-CD74 are related to axial spondyloarthritis (axSpA). The objectives were (i) to study IgA anti-CD74 in radiographic (r)-axSpA patients in the Backbone cohort and to calculate the sensitivity and specificity of anti-CD74, (ii) to study the fluctuation of IgA anti-CD74 levels in prospectively collected samples, and (iii) to explore the relation between IgA anti-CD

Artikeln fokuserar på hälso- och sjukvårdskuratorns arbete med att å ena sidan bemöta de känslor som barn och familjer kan känna efter att barnet diagnostiserats med den kroniska sjukdomen diabetes, å andra sidan han-tera olika byråkratiska processer som ska sörja för att barnets vårdbehov tillgodoses i familjens nya vardag. Arbetet riktas mot två olika världar som är inbördes beroende av varandraThe article focuses on the work of clinical social workers who, on the one hand, respond to the emotions that children and families experience after the child is diagnosed with the chronic disease diabetes, on the other hand, deal with various bureaucratic processes aimed at ensuring that the child’s medical needs are met in the family’s new life. The work is directed towards two different worlds