OBJECTIVE: Some patients regain weight to a variable extent from 1 year after Roux-en-Y gastric bypass surgery (RYGB), though rarely reaching preoperative values. The aim of the present study was to investigate whether, when, and to what extent metabolic remission occurs.METHODS: Fasting metabolite and lipid profiles were determined in blood plasma collected from a nonrandomized intervention study

Evidence of the effectiveness of the tests used to diagnose Helicobacter pylori (H. pylori) in primary healthcare is limited. This cross-sectional study aims to assess the accuracy of tests used for to diagnose H. pylori infection in primary care patients and its relationship with gastroduodenal pathologies. Over 12 months, 173 primary care patients with dyspeptic symptoms were referred for upper

In this book, I advance the concept of gender transculturation to illustrate how migrant consumers navigate contesting gender ideologies in their host cultural marketplace. Taking a consumer cultural theoretical perspective, the study lies in the nexus of and unpacks an alternative understanding in the current research frontier of consumer acculturation, gender and ideologies. Acculturation of imm

This paper explores social interaction in local public squares under different lighting conditions. At its best public squares are social spaces that engender a sense of belonging, increase the quality of life and wellbeing of individuals. It is proposed that outdoor lighting would be essential to the use of the public realm after dark, but empirical results regarding lighting conditions and socia

The way people order signs in non-verbal event representations of events has been a topic of extensive research in recent decades, with conflicting findings. Based on a literature review, we distinguish the following factors that have been argued to influence sign order: (a) diagrammatic iconicity, (b) manipulation vs. construction events, (c) reversibility, (d) most common word order of L1, (e) t

Genome-wide association studies have identified single nucleotide polymorphisms (SNPs) associated with waist circumference (WC) and waist-to-hip ratio (WHR) adjusted for BMI (WCadjBMI and WHRadjBMI), but it remains unclear whether these SNPs relate to change in WCadjBMI or WHRadjBMI with lifestyle intervention for weight loss. We hypothesized that polygenic scores (PS) comprised of 59 SNPs previou

Punctuality is a key factor in railway operations and is affected by both primary and secondary delays to differing degrees. Being able to separate these two types of delays is very important when simulating operations, and when conducting punctuality improvement efforts. However, it is not easy to estimate the relative proportions of primary versus secondary delays using historical data. In this

Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and m

Type 2 diabetes (T2D) is associated with low-grade inflammation. Here we investigate if the anti-inflammatorycytokine interleukin-4 (IL-4) affects glucose-stimulated insulin secretion (GSIS) in human islets from nondiabetic(ND) and type-2 diabetic (T2D) donors. We first confirmed that GSIS is reduced in islets from T2Ddonors. Treatment with IL-4 for 48 h had no further effect on GSIS in these isle

Purpose: Chronic inflammation is thought to initiate or promote differentiated thyroid cancer (DTC) and previous studies have shown that diet can modulate this inflammatory process. We aimed to evaluate the association of several dietary scores reflecting the inflammatory potential of the diet with DTC risk. Methods: Within the EPIC cohort, 450,063 participants were followed during a mean period o

Fatal intoxications with opioids are known to be associated with an increased lung weight, as well as with brain and pulmonary edema and urinary retention. However, there is evidence to suggest that fatal intoxications with non-opioid substances are also associated with increased lung weight; however, the latter aspect has not been comprehensively analyzed. To determine to what extent opioid and n

Objective. The diagnostic yield of sural nerve biopsy (SNB) in vasculitis is uncertain. Our aim was to document relevant characteristics of patients undergoing SNB in the investigation of vasculitis; determine the diagnostic yield; relate positive biopsy findings to patient demographic, laboratory, and clinical variables; and to calculate the rate of surgical complications. Methods. Patients with

Cartilage oligomeric matrix protein (COMP) is an emerging regulator of tumor progression. The aim of this study was to evaluate the expression of COMP in periampullary adenocarcinoma with respect to prognostic value for survival and relapse, levels of fibrosis and infiltrating immune cells. COMP expression was evaluated using immunohistochemistry in primary tumors and subsets of paired lymph node

BACKGROUND: Gestational diabetes mellitus (GDM) and type 2 diabetes mellitus (T2DM) share many pathophysiological factors including genetics, but whether epigenetic marks are shared is unknown. We aimed to test whether a DNA methylation risk score (MRS) for T2DM was associated with GDM across ancestry and GDM criteria.METHODS: In two independent pregnancy cohorts, EPIPREG (n = 480) and EPIDG (n =

Older adults are frequently exposed to medicines with systemic anticholinergic properties, which are linked to increased risk of negative health outcomes. The association between systemic anticholinergics and lung function has not been reported. The aim of this study was to investigate if exposure to systemic anticholinergics influences lung function in older adults. Participants of the southernmo

This paper will focus on a sense of place in prehistory. The chapter argues for the importance of the sensuous experiences of places, and in this case natural places, in the creation of memory and shared conceptions of place and landscape. Natural places played important roles in the process of creating the societal order in prehistory and in this respect can be considered similar to monuments in