Background: Achieving lasting remission for at least 2 years is a good indicator for favourable prognosis long term after Diffuse large B-cell lymphoma (DLBCL). The aim of this study was to provide real-world probabilities, useful in risk communication and clinical decision-making, of the chance for lasting remissions by clinical characteristics. Methods: DLBCL patients in remission after primary

The health of coastal marine environments is severely declining with global changes. Proxies, such as those based on microeukaryote communities, can record biodiversity and ecosystem responses. However, conventional studies rely on microscopic observations of limited taxonomic range and size fraction, missing putatively ecologically informative community components. Here, we tested molecular tools

Recent transport equity literature has proposed a sufficientarian approach to transport planning, according to which all individuals would be entitled to a minimum level of accessibility deemed adequate or sufficient. The implementation of this approach would require the adoption of an accessibility standard as a key performance indicator guiding transport investments, land use planning and servic

The paper presents ethical and legal challenges of holographic communication technologies and suggests a framework to address them. Holographic communications enable the capturing of a user’s 3D depiction via special equipment, and its high-quality transmission to another user located elsewhere, introducing a distinctive data communication experience. Their wrongful use could compromise basic huma

OBJECTIVE: Salt-inducible kinase 2 (SIK2) is abundantly expressed in adipocytes and downregulated in adipose tissue from individuals with obesity or insulin resistance. The main aims of this work were to investigate the involvement of SIKs in the regulation of glucose uptake in primary mature human adipocytes and to identify mechanisms underlying this regulation.METHODS: Primary mature adipocytes

Glucagon-like peptide-1 (GLP-1) receptor agonists are established pharmaceutical therapies for the treatment of type 2 diabetes and obesity. They mimic the action of GLP-1 to reduce glucose levels through stimulation of insulin secretion and inhibition of glucagon secretion. They also reduce body weight by inducing satiety through central actions. The GLP-1 receptor agonists used clinically are ba

Salt-inducible kinase 2 (SIK2) is highly expressed in white adipocytes, but downregulated in individuals with obesity and insulin resistance. These conditions are often associated with a low-grade inflammation in adipose tissue. We and others have previously shown that SIK2 is downregulated by tumor necrosis factor α (TNFα), however, involvement of other pro-inflammatory cytokines, or the mechanis

Epidemiological studies have associated plasma galectin-4 (Gal-4) levels with prevalent and incident diabetes, and with an increased risk of coronary artery disease. To date, data regarding possible associations between plasma Gal-4 and stroke are lacking. Using linear and logistic regression analyses, we tested Gal-4 association with prevalent stroke in a population-based cohort. Additionally, in

Throughout history packages are used to contain, store and transport goods and products. In early days it was a matter of gathering and storing locally, whereas in today’s global enterprises packaging is an important issue in the operational management in networks of functions and/or divisions, often separated geographically around the world. Packaging has become a part of the process of efficient

The work presented in this dissertation addresses two main topics: (i) graphene supported nanoparticles and their stability upon gas adsorption, and (ii) intercalation of different molecules under graphene and their reactions under graphene. From an interplay of X-ray photoelectron spectroscopy, scanning tunneling microscopy, low energy electron diffraction, and density functional theory an atomic

A lot of attention has been focused on the policy stream of the multiple streams framework (MSF). John Kingdon used the role of the policy entrepreneur to theorize what was going on when problems become political issues. In order to fully grasp this process we need to further theorize also the problem stream. What is going on in the problem stream is defining the conditions for coupling done by po

In the effort to separate pedestrian and bicycle traffic from motorised traffic the solution often is to let the pedestrians and bicyclists share space. However, combined pedestrian and bicycle paths lead to problems for both pedestrians and bicyclists; for pedestrians it is a security and safety problem and for bicyclists a mobility problem. Seniors and visually impaired pedestrians are especiall

The myriad of interpersonal relationships in tourism, between tourists, between tourists and locals, and between tourists and the service providers, are essential, generic components of the tourist experience. However, interpersonal relationships are emerging as a commercial value in the tourism industry as well, expressed for example in rural commercial home type of businesses, and in wellness-or