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Design and implementation of the European-Mediterranean Postgraduate Programme on Organ Donation and Transplantation (EMPODaT) for Middle East/North Africa countries

This prospective study reports the design and results obtained after the EMPODaT project implementation. This project was funded by the Tempus programme of the European Commission with the objective to implement a common postgraduate programme on organ donation and transplantation (ODT) in six selected universities from Middle East/North Africa (MENA) countries (Egypt, Lebanon and Morocco). The co

Citizens’ Communication Needs and Attitudes to Risk in a Nuclear Accident Scenario : A Mixed Methods Study

The potential devastation that a nuclear accident can cause to public health and the surrounding environment demands robust emergency preparedness. This includes gaining a greater knowledge of citizens’ needs in situations involving radiation risk. The present study examines cit-izens’ attitudes to a remediation scenario and their information and communication needs, using focus group data (n = 39

Exercise is associated with younger methylome and transcriptome profiles in human skeletal muscle

Exercise training prevents age-related decline in muscle function. Targeting epigenetic aging is a promising actionable mechanism and late-life exercise mitigates epigenetic aging in rodent muscle. Whether exercise training can decelerate, or reverse epigenetic aging in humans is unknown. Here, we performed a powerful meta-analysis of the methylome and transcriptome of an unprecedented number of h

Identifying blood biomarkers for type 2 diabetes subtyping : a report from the ORIGIN trial

Aims/hypothesis: Individuals with diabetes can be clustered into five subtypes using up to six routinely measured clinical variables. We hypothesised that circulating protein levels might be used to distinguish between these subtypes. We recently used five of these six variables to categorise 7017 participants from the Outcome Reduction with an Initial Glargine Intervention (ORIGIN) trial into the

Barking up the wrong tree? : A guide to forest owner typology methods

Creating typologies of forest owners is a common approach for analyzing and understanding heterogeneity in responses to forest policies and management practice uptake. While many forest owner typologies have been developed, only a few quantitative methods dominate the field with little information on how methodological choice affects outcomes. In this study we compare five methods for quantitative

Long-term health outcomes associated with hydration status

Body water balance is determined by fundamental homeostatic mechanisms that maintain stable volume, osmolality and the composition of extracellular and intracellular fluids. Water balance is maintained by multiple mechanisms that continuously match water losses through urine, the skin, the gastrointestinal tract and respiration with water gains achieved through drinking, eating and metabolic water

Operationalising resilience for disaster medicine practitioners: capability development through training, simulation and reflection

Resilience has in recent decades been introduced as a term describing a new perspective within the domains of disaster management and safety management. Several theoretical interpretations and definitions of the essence of resilience have been proposed, but less work has described how to operationalise resilience and implement the concept within organisations. This case study describes the impleme

Quality of life in patients with resectable rectal cancer during the first 24 months following diagnosis

Aim: An increasing number of patients survive rectal cancer, resulting in more patients living with the side-effects of the treatment. Exploring quality of life before and after treatment enables follow-up and additional treatment to be adjusted to the patient's needs. The aim of the study was to describe the quality of life during the 24 months following diagnosis and to identify risk factors for

Impact of Short-Term Lipid Overload on Whole-Body Physiology

Complex metabolic diseases due to overnutrition such as obesity, type 2 diabetes, and fatty liver disease are a major burden on the healthcare system worldwide. Current research primarily focuses on disease endpoints and trying to understand underlying mechanisms at relatively late stages of the diseases, when irreversible damage is already done. However, complex interactions between physiological

Assessing gene flow between Dicranum scoparium Hedw. and D. bonjeanii De Not. (Dicranaceae) using single nucleotide polymorphisms (SNPs)

While hybridisation in vascular plants has received considerable attention, hybridisation in bryophytes is still relatively understudied. Here we investigate hybridisation between two species from the moss genus Dicranum Hedw. Dicranum scoparium Hedw. and D. bonjeanii De Not. are two moss species of the D. scoparium species complex with partially overlapping morphology and habitat ranges. This stu

The Association of Cardiometabolic, Diet and Lifestyle Parameters With Plasma Glucagon-like Peptide-1 : An IMI DIRECT Study

Context: The role of glucagon-like peptide-1 (GLP-1) in type 2 diabetes (T2D) and obesity is not fully understood. Objective: We investigate the association of cardiometabolic, diet, and lifestyle parameters on fasting and postprandial GLP-1 in people at risk of, or living with, T2D. Methods: We analyzed cross-sectional data from the two Innovative Medicines Initiative (IMI) Diabetes Research on P

Effect of Extruded Mortar Joints on Mould Growth in Timber Frame Wall with Brick Veneer : Probabilistic and Machine Learning Modelling

Extruded mortar joints, resulting from suboptimal workmanship in bricklaying, bridge air gaps within cavity external walls. This phenomenon establishes a connection between brick masonry claddings and adjacent layers (such as insulation or weather-resistive barriers), inadvertently intensifying water penetration due to wind-driven rain (WDR) loads. This study utilises a probabilistic analysis in c