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Heart failure (HF) is a leading cause of death and disability globally. Heritable factors and the extent and pattern of myocardial fibrosis are important determinants of outcomes in patients with HF. In a genome-wide association study of mortality in HF, we recently identified a genetic polymorphism on chromosome 5q22 associated with HF mortality. Here, we sought to study the mechanisms by which t

Creating typologies of forest owners is a common approach for analyzing and understanding heterogeneity in responses to forest policies and management practice uptake. While many forest owner typologies have been developed, only a few quantitative methods dominate the field with little information on how methodological choice affects outcomes. In this study we compare five methods for quantitative

Several authors have described how the formalization of recent decades has steered doctoral education towards structured curricula, more managerial control and new models for supervision. Largely absent from these accounts, however, is if and how doctoral education has been affected by the concurrent changes in research governance, in particular by the ‘projectification’ of research. For this studSeveral authors have described how the formalization of recent decades has steered doctoral education towards structured curricula, more managerial control and new models for supervision. Largely absent from these accounts, however, is if and how doctoral education has been affected by the concurrent changes in research governance, in particular by the ‘projectification’ of research. For this stud

Enolase-1 (Eno1) plays a critical role in regulating glucose metabolism; however, its specific impact on pancreatic islet β-cells remains elusive. This study aimed to provide a preliminary exploration of Eno1 function in pancreatic islet β-cells. The findings revealed that the expression of ENO1 mRNA in type 2 diabetes donors was significantly increased and positively correlated with HbA1C and neg

The formation of metamorphic zircon after baddeleyite is a well-known reaction that can be used to date the metamorphism of igneous silica-undersaturated rocks. By contrast, metamorphic minerals formed after igneous zirconolite have rarely been reported. In this paper, we document metamorphic titanite + zircon pseudomorphs formed from the metamorphic breakdown of igneous zirconolite in syenodiorit

Body water balance is determined by fundamental homeostatic mechanisms that maintain stable volume, osmolality and the composition of extracellular and intracellular fluids. Water balance is maintained by multiple mechanisms that continuously match water losses through urine, the skin, the gastrointestinal tract and respiration with water gains achieved through drinking, eating and metabolic water

Purpose: This article reports on jaw articulation, in connection with the segmental articulations of tongue tip and lips. The jaw is considered a syllable articulator as it opens and closes for each syllable, and the amount of jaw opening is related to syllable strength, given the same phonemic vowel. Here, we investigate the syllabic and the segmental articulations relationships to the acoustic s

The deliberation that precedes or runs alongside the remaking of cities, buildings and landscapes seem almost by default to generate situations with unsatisfied stakehold-ers, neglected citizen groups or completely ignored voices. What does it mean to find, listen and respond to those concerned by alteration of built environments? Here, in this paper, citizen participation, its ideological and pol

High-fat diet-induced metabolic changes are not restricted to the onset of cardiovascular diseases, but also include effects on brain functions related to learning and memory. This study aimed to evaluate mitochondrial markers and function, as well as cognitive function, in a rat model of metabolic dysfunction. Eight-week-old male Wistar rats were subjected to either a control diet or a two-hit pr

'Drawing from contributions by scholars of entrepreneurship from North America, Western Europe and Asia, this edited book celebrates the vibrancy and interdisciplinarity of entrepreneurship research. It showcases the renewed importance of entrepreneurship studies in the social sciences. New Movements in Entrepreneurship is a tour de force in entrepreneurship studies that must not be missed. It's b

Aim: An increasing number of patients survive rectal cancer, resulting in more patients living with the side-effects of the treatment. Exploring quality of life before and after treatment enables follow-up and additional treatment to be adjusted to the patient's needs. The aim of the study was to describe the quality of life during the 24 months following diagnosis and to identify risk factors for

High-quality diets have been increasingly acknowledged as a promising candidate to counter the growing prevalence of mental health disorders. This study aims to investigate the prospective associations of adhering to the EAT-Lancet reference diet with incident depression, anxiety and their co-occurrence in 180,446 UK Biobank participants. Degrees of adherence to the EAT-Lancet diet were translated

Testing of autonomous driving systems (ADS) is a crucial, yet complex task that requires different approaches to ensure the safety and reliability of the system in various driving scenarios. Currently, there is a lack of understanding of the industry practices for testing such systems, and also the related challenges. To this end, we conduct a secondary analysis of our previous exploratory study,

Urban Lives emphasizes the importance of a micro-level approach in examining the lives of individuals and families in an industrial city, spanning over a century. The work deepens the understanding of major societal shifts and how they are intertwined with demographic behavior over the past 120 years. These societal transformations encompassed groundbreaking advancements in living standards, a rel

According to popular understandings, children grow from a state of dependence to eventually become independent adults. Interdependence helps to disrupt the in/dependence binary and is a useful concept for making sense of the experiences young people with variations in sex characteristics in relation to healthcare. This study used semi-structured interviews with 32 health professionals, 33 caregive