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This position paper by the European Society for Paediatric Gastroenterology, Hepatology and Nutrition (ESPGHAN) Special Interest Group on Coeliac Disease (SIG-CD) presents an update to the 2016 recommendations concerning early diet and the risk of coeliac disease (CD). This update adheres to the policy that mandates reviewing guidelines every 5 years, particularly when new data emerge. The 2024 st
This presentation focuses the emotional dilemmas of social workers who recruit and assess foster parents, in a context increasingly defined by market dynamics. Following privatization paralleled with increasing need for childcare, private and public actors today compete to contract potential foster parents in Sweden. For this paper, 43 interviews (with social workers and managers), 21 observation
Obesity and type 2 diabetes are increasing at alarming rates worldwide, presenting significant public health challenges. A key player in these conditions is GLUT4, a protein that helps transports glucose into cells in response to insulin. Proper function of GLUT4 is crucial for maintaining healthy blood sugar levels and overall metabolic health.To address this, in this thesis I have explored the m
OBJECTIVE: To investigate the relationship between the fraction of fetal haemoglobin (HbF(%)) and oxygen requirement as determined by the fraction of inspired oxygen (FiO2) and alveolar-arterial gradient (A-a gradient). Increased alveolar exposure to oxygen may explain the association between decreased HbF(%) and the development of bronchopulmonary dysplasia (BPD).DESIGN: Longitudinal, retrospecti
The importance of reducing environmental impacts has gained speed in the contemporary global context. Stabilization/Solidification (S/S) has become a practical method for handling polluted dredged sediments to make them usable as a construction material. This study aims to evaluate the environmental and economic impacts of a 48,586 m2 port, with stabilized dredged sediment, by focusing on the prod
One of the most challenging aspects of X-ray research is the delivery of liquid sample flows into the soft X-ray beam. Currently, cylindrical microjets are the most commonly used sample injection systems for soft X-ray liquid spectroscopy. However, they suffer from several drawbacks, such as complicated geometry due to their curved surface. In this study, we propose a novel 3D-printed nozzle desig
For a century, transport systems have been governed by masculine norms, constraining both women and men within the conditions and mobility behaviour it has established. This article explores the potential implications of adopting feminine norms for mobility and transport systems. Current masculine mobility norms are contested by investigating what including a feminine mobility concept would entail
Background: Altered metabolism after liver surgery adds complexity topostoperative pain management. Opioids administered via intravenousPatient Controlled Analgesia (PCA) is one of the main alternatives forinitial pain management. Paracetamol is considered potentially dangerousafter liver surgery but used selectively. This study evaluates whether thereis a difference in patient outcome after hepat
This chapter analyses the role that 'ordre public' and morality exceptions can play in the granting of patents on inventions in the field of human germline editing and the consequences of this policy option. In order to provide the context for such an analysis, the chapter will, first, provide an overview of the current patent landscape for relevant genome editing technologies, drawing attention t
Aim: There is ongoing controversy regarding the extent to which Hartmann's procedure (HP) should be used in rectal cancer treatment. This study was designed to investigate 30-day postoperative morbidity and mortality following HP, anterior resection (AR) and abdominoperineal resection (APR) for rectal cancer using a national registry. Methods: All patients operated for rectal cancer, tumour height
Politiska organisationer anställer ofta, och i allt högre utsträckning, utredare och andra kunskapsarbetare för att producera kunskap och politiska förslag, och den svenska fackliga centralorganisationen LO har sedan 1930-talet anställt nationalekonomer och andra samhällsvetare. Genom analys- och presentationsmetoder som liknar den akademiska samhällsvetenskapen, och genom interaktion med talesper
PURPOSE: We studied the relative contributions of total peripheral resistance (TPR), stroke volume (SV) and heart rate (HR) to low blood pressure in classical orthostatic hypotension (cOH) on group and individual levels.METHODS: We retrospectively analyzed tilt test records from cOH patients and age/sex-matched controls. We quantified relative effects of HR, SV and TPR on mean arterial pressure (M
Diabetic retinopathy (DR) continues to be the primary cause of vision loss in poorly controlled diabetic subjects. The molecular mechanisms underlying retinal pigment epithelium (RPE) cell dysfunction in DR still remain elusive. We investigated the role of mitochondrial volt-age-dependent anion channel 1 (VDAC1) in RPE dysfunction under glucotoxic and inflammatory conditions. Our results demonstra
Green innovations sometimes have a debatable environmental impact, which could be related to how their adopters use them. This paper examines five factors encompassing a consumer trait of being innovative and various motivations that could help further understand the adoption of controversial green innovations. Mainly, this paper examines the use decision and users' behavioral intentions in two gr
Introduction: Infective endocarditis (IE) is a challenging diagnosis to suspect and to confirm. The purpose of this study was to clarify how often IE is suspected already on hospital admission, which clinical signs trigger the physicians’ suspicions and to investigate if the empirical treatment is adequate. Methods: A retrospective observational study of cases with definitive IE, during 2018–2019
The goal of the TEDDY (The Environmental Determinants of Diabetes in the Young) study is to elucidate factors leading to the initiation of islet autoimmunity (first primary outcome) and those related to progression to type 1 diabetes mellitus (T1DM; second primary outcome). This Review outlines the key findings so far, particularly related to the first primary outcome. The background, history and
Genetic variation at the 19q13.3 KLK locus is linked with prostate cancer susceptibility in men. The non-synonymous KLK3 single nucleotide polymorphism (SNP), rs17632542 (c.536 T > C; Ile163Thr-substitution in PSA) is associated with reduced prostate cancer risk, however, the functional relevance is unknown. Here, we identify that the SNP variant-induced change in PSA biochemical activity mediates
