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Berberine, an isoquinoline alkaloid derived from various medicinal plants, emerges as a potential therapeutic agent against diverse human diseases. It has particularly shown notable anticancer efficacy against breast, colorectal, lung, prostate, and liver cancer. Berberine results in inhibition of cancer cell proliferation, induction of apoptosis, and suppressing angiogenesis, positioning it as a
Background: There is still much to learn about the explanation for the often-found negative association between sibship size and different child outcomes. A plausible explanation is resource competition between siblings in larger families, as suggested by the resource dilution hypothesis. Objective: This study contributes to our understanding of these mechanisms by investigating the association be
Premature ovarian failure (POF) is a perplexing condition in women characterized by cessation of oocyte production in the ovaries. Despite numerous proposed causes for the development of POF, the actual cause of the most POF cases remains unknown. Given that POF significantly affects fertility and is a devastating diagnosis for women, there is an urgent need for the development of new therapies ai
HLA-DR genes are associated with the progression from stage 1 and stage 2 to onset of stage 3 type 1 diabetes (T1D), after accounting HLA-DQ genes with which they are in high linkage-disequilibrium. Based on an integrated cohort of participants from two completed clinical trials, this investigation finds that sharing a haplotype with the DRB1*03:01 (DR3) allele, DRB3*01:01:02 and *02:02:01 have re
BACKGROUND: The climacteric is the period in a woman's life that includes the transition from reproductive to non-reproductive. The woman's experience is individual, but common symptoms include irregular bleeding patterns, hot flashes, sweating, and sleep problems. Primary care should be the first instance for women seeking treatment for menopausal symptoms, and the district nurse thus plays a vit
Autoimmune thyroid disease (AITD) is associated with other autoimmune endocrine diseases such as type 1 diabetes (T1D) and celiac disease (CeD). Thyroid peroxidase autoantibodies (TPOA) are biomarkers of AITD but may also occur in patients with other autoimmune diseases. We examined cross-sectional correlations between TPOA and an array of immune markers in a cohort of 90 children with exclusively
In some languages, prosodic cues on word stems can be used to predict upcoming suffixes. Previous studies have shown that second language (L2) users can process such cues predictively in their L2 from approximately intermediate proficiency. This ability may depend on the mapping of the L2 prosody onto first language (L1) perceptual and functional prosodic categories. Taking as an example the Danis
Introduction: The climate and biodiversity crises are interconnected, unprecedented, existential threats that cause disturbing emotions, such as anxiety, grief, and anger. While there is increasing research about antecedents and outcomes of such eco-emotions, less is known about how to cope with them constructively, to benefit both mental health and pro-environmental action. Objectives: This study
The increasing global concern for greenhouse gas emissions has led to a fast pace in the transition away from fossil fuels in the transport sector. The share of electric passenger cars is increasing quickly, introducing new loads on the power grid. These loads primarily appear at the distribution grid level, where most of the charging occurs in the form of overnight charging at home. Although the
Predicting pathogen emergence and spillover risk requires understanding the determinants of a pathogens host range and the traits involved in host competence. While host competence is often considered a fixed species-specific trait, it may be variable if pathogens diversify across hosts. Balancing selection can lead to maintenance of pathogen polymorphisms (multiple-niche-polymorphism; MNP). The c
Background and purpose - Intramedullary nails (IMN) have become increasingly common as treatment for trochanteric hip fractures (THF) although they are costlier, and without proven superiority compared with sliding hip screws (SHS). We investigated whether the 2 methods differ in terms of short-term mortality when used in fractures where both methods are suitable. Patients and methods - We extract
Disturbances of the gut microbiota may influence the development of various autoimmune diseases. This study investigated the effects of supplementations with the probiotic bacteria, Lactiplantibacillus plantarum HEAL9 and Lacticaseibacillus paracasei 8700:2, on the microbial community in children with celiac disease autoimmunity (CDA). The study included 78 genetically predisposed children for cel
Development of islet autoimmunity precedes the onset of type 1 diabetes in children, however, the presence of autoantibodies does not necessarily lead to manifest disease and the onset of clinical symptoms is hard to predict. Here we show, by longitudinal sampling of islet autoantibodies (IAb) to insulin, glutamic acid decarboxylase and islet antigen-2 that disease progression follows distinct tra
Background: Most patients with kidney disease have different degrees of proteinuria. Heavy proteinuria causes nephrotic syndrome. The incidences of nephrotic syndrome in adults are approximately three per 100 000 persons. Although if nephrotic syndrome is rare, it is a serious clinical condition. Little is known about health and wellbeing among patients with nephrotic syndrome. It is important for
Interdependent critical infrastructure systems represent substantial financial investments and are vital to maintain a fundamental level of social and economic well-being, making them attractive targets for malevolent actors. Many of these infrastructure systems carry multiple products, each with unique needs and importance to different stakeholders. This work extends a tri-level protection-interd
Body water balance is determined by fundamental homeostatic mechanisms that maintain stable volume, osmolality and the composition of extracellular and intracellular fluids. Water balance is maintained by multiple mechanisms that continuously match water losses through urine, the skin, the gastrointestinal tract and respiration with water gains achieved through drinking, eating and metabolic water
Purpose: This article reports on jaw articulation, in connection with the segmental articulations of tongue tip and lips. The jaw is considered a syllable articulator as it opens and closes for each syllable, and the amount of jaw opening is related to syllable strength, given the same phonemic vowel. Here, we investigate the syllabic and the segmental articulations relationships to the acoustic s
