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Previous studies have suggested that dietary factors may be important in the development of bladder cancer. We examined macronutrient intake in relation to risk of urothelial cell carcinoma among 469,339 men and women in the European Prospective Investigation into Cancer and Nutrition. Associations were examined using Cox regression, stratified by sex, age at recruitment and centre and further adj

A rare loss-of-function allele p.Arg138* in SLC30A8 encoding the zinc transporter 8 (ZnT8), which is enriched in Western Finland, protects against type 2 diabetes (T2D). We recruited relatives of the identified carriers and showed that protection was associated with better insulin secretion due to enhanced glucose responsiveness and proinsulin conversion, particularly when compared with individual

In an attempt to at the same time introduce new technology into the existing public transport network, investigate the impact of this technology on street space in cities and present a solution to the problem with congestion in dense city centers a model is introduced. This model demonstrates one way to implement autonomous vehicles in the public transport network in dense city centers. The result

Due to an increasing ease of access to social media outlets, more tourists than ever are able to share their comments, images and videos of travel experiences. As such this user generated content is said to have more of an impact than professionally produced content on the decisions of prospective travellers. On this basis the major objective of this study is to identify the overall perspectives h

Abstract: Previous research has found car-sharing schemes to have great potential, internationally and locally, to reduce greenhouse gas emissions from the personal transport sector, and contain significant locally bounded advantages with implications for improved urban sustainable mobility and more efficient land-use. The aim of the paper is to explore how and why shared mobility services, specif

The PRDM family of methyltransferases has been implicated in cellular proliferation and differentiation and is deregulated in human diseases, most notably in cancer. PRDMs are related to the SET domain family of methyltransferases; however, from the 19 PRDMs only a few PRDMs with defined enzymatic activities are known. PRDM15 is an uncharacterized transcriptional regulator, with significant struct

Aquaglyceroporin 7 (AQP7) facilitates glycerol flux across the plasma membrane with a critical physiological role linked to metabolism, obesity, and associated diseases. Here, we present the single-particle cryo-EM structure of AQP7 determined at 2.55 Å resolution adopting two adhering tetramers, stabilized by extracellularly exposed loops, in a configuration like that of the well-characterized in

As retail is becoming increasingly digitised in its operation and consumer relationships, much faith is put into automation, prediction and insights drawn from consumer data to shape consumer experiences and expectations. Under the umbrella of data-collection and artificial intelligence (AI), this chapter studies the role of consumer trust in retail personalisation. We draw empirical insights from

The purpose of this essay is to examine the concept of competence within the social services. More specifically it aims to find out how the social workers themselves look upon their own competence in social investigations concerning children. As the study was based on focus groups the main questions were vague at the beginning and were cleared later on during the group sessions. In three focus gr

It is claimed by several Western experts that the citizens are loosing confidence in their politicians. If true, it poses a serious threat to the legitimacy of the decisions made by politicians. The answer to this claimed lack of trust could be found in the politician role, because this role is the link between the mass and the political institutions. Politicians act as the representatives of the

Internet has made information more easy to get, but also more difficult to retrieve. There is a need for information retrieval systems that assure accurate, reliable and up to date information. Quite a number of both commercial and non commercial search services has been developed on the Internet. We have made a qualitative study of one for-pay product in particular, NetS k, produced by BTJ (Bibli

BACKGROUND: Pancreatic ductal adenocarcinoma (PDAC) represents the fourth cause of death in cancer with a 5-year survival rate of less than 1-2%. Early onset pancreatic cancer (EOPC), i.e. patients below 50 years of age, is infrequently described. The present study aimed to determine the epidemiology, demographic incidence and prognosis of EOPC and to identify the characteristics that might distin