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Optic neuritis (ON) is associated with numerous immune-mediated inflammatory diseases, but 50% patients are ultimately diagnosed with multiple sclerosis (MS). Differentiating MS-ON from non-MS-ON acutely is challenging but important; non-MS ON often requires urgent immunosuppression to preserve vision. Using data from the United Kingdom Biobank we showed that combining an MS-genetic risk score (GR

The primary function of cyclin-dependent kinases (CDKs) in complex with their activating cyclin partners, is to promote mitotic division in somatic cells. This canonical cell cycle-associated activity is also crucial for fertility as it allows the proliferation and differentiation of stem cells within the reproductive organs to generate meiotically competent cells. Intriguingly several CDKs exhibi

Cosmology concepts encompass complex spatial and temporal relations that are counterintuitive. Cosmology findings, because of their intrinsic interest, are often reported in the public domain with enthusiasm, and students come to cosmology with a range of conceptions some aligned and some at variance with the current science. This makes cosmology concepts challenging to teach, and also challenging

During the past decade, many parliamentary democracies have experienced bargaining delays when forming governments. The previous literature has attributed protracted government formation processes to a high degree of preference uncertainty among the political parties and a high level of bargaining complexity. The article draws on such theories, but also adds a third theoretical mechanism, commitme

Despite laws, policies, and political visions to create cities and societies for all, barriers still exclude people from using buildings and public places. The commitments made in global agreements such as the Convention on Rights for Persons with Disabilities (CRPD) and the 2030 Agenda for Sustainable Development require significant changes in urban planning to meet the variety of needs and condi

Background and aimsPrior studies have suggested that the benefit from primary preventive defibrillator treatment for patients with non-ischemic cardiomyopathy primarily, treated with cardiac resynchronization therapy, may be age-dependent. We aimed to compare age-stratified mortality rates and mode of death in patients with non-ischemic cardiomyopathy who are treated with either primary preventive

Bonus relations (such as step-grandparents, step-grandchildren, and families of choice) can be chosen, or they can be forced up on you, they can be regarded as very important to extremely peripheral. Bonus relations negotiate familiarity and can vary from inclusion to exclusion. Common to bonus-relations are their non-biological aspect: they are not blood-line relations, and to many families and fBonus relations (such as step-grandparents, step-grandchildren, and families of choice) can be chosen, or they can be forced up on you, they can be regarded as very important to extremely peripheral. Bonus relations negotiate familiarity and can vary from inclusion to exclusion. Common to bonus-relations are their non-biological aspect: they are not blood-line relations, and to many families and f

The Sustainable Business Model Canvas (SBMC) offers a useful tool for business model design, as it manages to integrate all three dimensions of sustainability without distinguishing between three different layers (economic, environmental, and social). This paper presents the application of SBMC in a real study case of a one-stop-shop (OSS) for the renovation of single-family houses operating inKro

Glucagon is the principal glucose-elevating hormone that forms the first-line defence against hypoglycaemia. Along with insulin, glucagon also plays a key role in maintaining systemic glucose homeostasis. The cells that secrete glucagon, pancreatic α-cells, are electrically excitable cells and use electrical activity to couple its hormone secretion to changes in ambient glucose levels. Exactly how

In a series of articles Dörnyei and his colleagues (Dörnyei, Ibrahim, & Muir, 2015; Dörnyei, Muir, & Ibrahim, 2014; Muir & Dörnyei, 2013) describe the phenomenon of a period of intense and enduring motivation in pursuit of a highly desired personal goal or vision. These surges of motivational energy, which they call Directed Motivational Currents (DMCs), uniquely differ from other type

Motivational strategies are underresearched, and studies so far conducted have been in sociolinguistic contexts where English is not extensively encountered outside the classroom. Given also that little is known about strategies relating to the design and content of classroom activities, the purpose of this study is to identify and critically evaluate strategies focusing on activity design and con

This conceptual article focuses on student engagement, and the use of digital games in language classrooms. In making a contribution to the mapping of student engagement across SLA (Dörnyei, 2019a), and in line with the need to use established theories to develop insights into engagement when L2 learning involves digital games, a case is made for the concept of immersion (Brown & Cairns, 2004)

When imaging (i.e., chest-x-ray or computed tomography) is used to differentiate between acute bronchitis and pneumonia, many patients are being prescribed antibiotics despite the absence of radiographic pneumonia signs. This study of lower respiratory tract infections (LRTIs) with negative chest imaging compares cases where antibiotics were prescribed and not prescribed to find characteristics th

Alteration of natural disturbances in human-modified landscapes has resulted in many disturbance-dependent species becoming rare. Conservation of such species requires efforts to maintain or recreate disturbance regimes. We compared benefits of confining efforts to habitats in protected areas (a form of land sparing) versus integrating them with general management of production land (a form of lan

Guided by the social-cognitive theory and self-determination theory, this study examined whether moral disengagement is indirectly associated with pro-bullying, passive bystanding, and defending, mediated by autonomous motivation, introjected motivation, extrinsic motivation, and amotivation to defend victims of bullying among early adolescents. Participants were 901 upper elementary students from