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Numerous genetic loci have been associated with systolic blood pressure (SBP) and diastolic blood pressure (DBP) in Europeans(1-3). We now report genome-wide association studies of pulse pressure (PP) and mean arterial pressure (MAP). In discovery (N = 74,064) and follow-up studies (N = 48,607), we identified at genome-wide significance (P = 2.7 x 10(-8) to P = 2.3 x 10(-13)) four new PP loci (at
Circulating metabolites associated with insulin sensitivity may represent useful biomarkers, but their causal role in insulin sensitivity and diabetes is less certain. We previously identified novel metabolites correlated with insulin sensitivity measured by the hyperinsulinemic-euglycemic clamp. The top-ranking metabolites were in the glutathione and glycine biosynthesis pathways. We aimed to ide
Complement activation protects against infection but also contributes to pathological mechanisms in a range of clinical conditions such as autoimmune diseases and transplant rejection. Complement-inhibitory drugs, either approved or in development, usually act systemically, thereby increasing the risk for infections. We therefore envisioned a novel class of bispecific antibodies (bsAbs) which are
De novo mutations (DNMs) are drivers of genetic disorders. However, the study of DNMs is hampered by technological limitations preventing accurate quantification of ultra-rare mutations. Duplex Sequencing (DS) theoretically has < 1 error/billion base-pairs (bp). To determine the DS utility to quantify and characterize DNMs, we analyzed DNA from blood and spermatozoa from six healthy, 18-year-old S
OBJECTIVES: Carbapenem- and colistin-resistant Klebsiella pneumoniae were isolated from war victims treated in hospitals in Ukraine. The question was whether these pandrug-resistant K. pneumoniae are pathogenic and capable of causing disease in a broader context.METHODS: Klebsiella pneumoniae clinical isolates (n = 37) were tested for antibiotic resistance and subjected to whole-genome sequencing
Magnetic resonance spectroscopy (MRS) has been employed to investigate brain metabolite concentrations in vivo, and they vary during neuronal activation, across brain activity states, or upon disease with neurological impact. Whether resting brain metabolites correlate with functioning in behavioral tasks remains to be demonstrated in any of the widely used rodent models. This study tested the hyp
Purpose: Resilience has been suggested as an important predictor of both physical and mental health-related quality of life in breastcancer patients. However, it is unclear why resilient women handle their diagnosis better, not only mentally, but also physically. Theaim of this study was to investigate paths between resilience, physical activity, and mental, physical, and global health-related qua
Background: Shared spaces are intended to constitute an attractive urban space for everyone by blending protected and unprotected road users. However, our previous study showed that pedestrians prefer the traditional division between protected and unprotected road users, at the same time as elderly pedestrians focused less on traffic when the division was recreated by large flowerpots. Objective:
Post-marketing reports of suspected adverse drug reactions are important for establishing the safety profile of a medicinal product. However, a high influx of reports poses a challenge for regulatory authorities as a delay in identification of previously unknown adverse drug reactions can potentially be harmful to patients. In this study, we use natural language processing (NLP) to predict whether
In this study, we investigated the prevalence of mental disorders and the use of psychopharmacologic drugs among individuals with cerebral palsy (CP). We studied how the association between CP and mental illness develops over the life course (between ages 5 and 65 years), and how it varies across disability specific factors (intellectual disability, gross motor function and communicative ability).
Introduction: Studies suggest that experiences of patient participation, as described by both patients and staff, are associated with a significant caring relationship of high quality. Aim: This study aimed to investigate staffs' and patients' self-reported perceptions on participation and the frequency and importance of verbal and social interactions in high-security forensic psychiatry. Method:
Diverse forest landscapes contribute to reaching various forest policy goals. Understanding how the diversity of forests in a landscape is distributed among forest properties and how it is related to biogeographical and ownership factors can be helpful for effective policy implementation. We created a forest characteristics-based typology of non-industrial private forest properties aiming to captu
Since 2021, the DarkLab at Lund University (LU) and the Digital Research Service at the French National Institute of Art History (INHA) have collaborated to develop state-of-the-art digital systems and tools for the management and publication of archaeological data, including information from fieldwork and artefact collections. Drawing on the combined expertise of both institutions, this partnersh
